Protein
Modification methylase CviRI
Organism
Paramecium bursaria Chlorella virus XZ-6E
Function
This methylase recognizes the double-stranded sequence TGCA, causes specific methylation on A-4 on both strands, and protects the DNA from cleavage by the CviRI endonuclease.
Similarity
Belongs to the N(4)/N(6)-methyltransferase family.
Sequence
MKLFEDKSVEFHKRLSKKERSDGGVFFTPKDIRDIVFEELGDFEPTNILEPTCGTGEFISDCRKVYKNSRIIGVEIDPRSAELARDGSKNEIIVHDFMTWDTDEKFDLIIGNPPYFTRPTGFKHDPSVVKCRSNICIEVLHKCITRHLADNGMLAMVLPVSILNSKFYTPTIDLITDTMDVVSARAIKKNNFMGTNVRVMVFIIRKRTPGFVSKYTFKTSLGKVIINPDGERLGSIVSGKKTIGSLNVNISFGVTLASVKEYFVDKSCSGSFPLICYNNIAKKGDLLFVSDKYSKKRFNGRAILIPRGYAHGDYSFNFIDYTNDYFIIENHVIAITGEDCVLDIIAKSFADHRTREFCRLLCSSGDISKDYVKEIPVFG