CUEDC2

CUE domain-containing protein 2

287 amino acids

Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.

Belongs to the CUEDC2 family.

32.009 kDa

MELERIVSAALLAFVQTHLPEADLSGLDEVIFSYVLGVLEDLGPSGPSEENFDMEAFTEMMEAYVPGFAHIPRGTIGDMMQKLSGQLSDARNKENLQPQSSGVQGQVPISPEPLQRPEMLKEETRSSAAAAADTQDEATGAEEELLPGVDVLLEVFPTCSVEQAQWVLAKARGDLEEAVQMLVEGKEEGPAAWEGPNQDLPRRLRGPQKDELKSFILQKYMMVDSAEDQKIHRPMAPKEAPKKLIRYIDNQVVSTKGERFKDVRNPEAEEMKATYINLKPARKYRFH

CUEDC2

CUE domain-containing protein 2

287 amino acids

Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.

Belongs to the CUEDC2 family.

32.009 kDa

MELERIVSAALLAFVQTHLPEADLSGLDEVIFSYVLGVLEDLGPSGPSEENFDMEAFTEMMEAYVPGFAHIPRGTIGDMMQKLSGQLSDARNKENLQPQSSGVQGQVPISPEPLQRPEMLKEETRSSAAAAADTQDEATGAEEELLPGVDVLLEVFPTCSVEQAQWVLAKARGDLEEAVQMLVEGKEEGPAAWEGPNQDLPRRLRGPQKDELKSFILQKYMMVDSAEDQKIHRPMAPKEAPKKLIRYIDNQVVSTKGERFKDVRNPEAEEMKATYINLKPARKYRFH

Cuedc2

CUE domain-containing protein 2

284 amino acids

Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation.

Belongs to the CUEDC2 family.

31.852 kDa

MELERIVGSALLTFVQAHLPEADLSGLDEVIFSYVLGVLEDLGPSGPSEENFDMEAFTEMMEAYVPGFAHIPRGIIGDMMQKLSVQLSDARNKENLHPQSSCVQGQVPIFPETPRQAEKLEEESRPPAAPGNTLDEAAAAEELPGVDVLLEVFPTCSMEQAQWVLAKARGDLEEAVHMLVEGKEEGPPGWDGPSQDLPRRLRGPQKDDLKSFILQKYMMVDRAEDQKTHRPMAPKEAPKKLIRYIDNQVVSTKGERFKDVRNPEAEEMKATYINLKPARKYRFH

Cuedc2

CUE domain-containing protein 2

284 amino acids

Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation.

Belongs to the CUEDC2 family.

31.852 kDa

MELERIVGSALLTFVQAHLPEADLSGLDEVIFSYVLGVLEDLGPSGPSEENFDMEAFTEMMEAYVPGFAHIPRGIIGDMMQKLSVQLSDARNKENLHPQSSCVQGQVPIFPETPRQAEKLEEESRPPAAPGNTLDEAAAAEELPGVDVLLEVFPTCSMEQAQWVLAKARGDLEEAVHMLVEGKEEGPPGWDGPSQDLPRRLRGPQKDDLKSFILQKYMMVDRAEDQKTHRPMAPKEAPKKLIRYIDNQVVSTKGERFKDVRNPEAEEMKATYINLKPARKYRFH

CUEDC2

CUE domain-containing protein 2

283 amino acids

Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation.

Belongs to the CUEDC2 family.

31.532 kDa

MELERIVSAALLAFVQTHLPEADLSGLDDVIFSYVLGVLGDLGPSGPSEENFDMEAFTEMMEAYVPGFAHIPRGTIGDMIQKLSGQLSGARNKENVQPQSSEVQGQVSISPEPLQRPEKLKEETMSSAGDTQDEAAGPEEELLPGVDVLLEVFPTCSVEQAQWVLAKARGDLEEAVQMLVEGKQGPPAWDGPNQDLPRRLRGPQKDELKSFILQKYMMVDSAEDQKIHRPMAPKEAPKKLIRYIDNQIVSTKGERFKDVRNPEAEEMKATYINLKPARKYRFH

CUEDC2

CUE domain-containing protein 2

283 amino acids

Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation.

Belongs to the CUEDC2 family.

31.532 kDa

MELERIVSAALLAFVQTHLPEADLSGLDDVIFSYVLGVLGDLGPSGPSEENFDMEAFTEMMEAYVPGFAHIPRGTIGDMIQKLSGQLSGARNKENVQPQSSEVQGQVSISPEPLQRPEKLKEETMSSAGDTQDEAAGPEEELLPGVDVLLEVFPTCSVEQAQWVLAKARGDLEEAVQMLVEGKQGPPAWDGPNQDLPRRLRGPQKDELKSFILQKYMMVDSAEDQKIHRPMAPKEAPKKLIRYIDNQIVSTKGERFKDVRNPEAEEMKATYINLKPARKYRFH

cuedc2

CUE domain-containing protein 2

282 amino acids

May play a role in targeting proteins for ubiquitination and subsequent proteasomal degradation.

Belongs to the CUEDC2 family.

31.712 kDa

MDLQKIIHDALYDFILSYIPHADLSTLDDVILSYITGVLEDLGSQESVEENFDVEVFVEMLEAYIPGFSDIDSVKVCEMMFNLAAKLTSARDTESGEMKIEEGKFPLSESCDLSLGGSREKTHNLTLQAEGATAQVSESSWDNQEQHLLEMFPKCSVTEARSALSIAKGDMEEAVRLIIEGDVQLKCPPSLSANQGKTVSAEVDQKLKASILEKYMLVDDEEDKKVHRPVTPKDAPKKMVRYHGSQVVTTKGERYHLVKKEEPEDMKKTYVSLKPARKYRFH

cuedc2

CUE domain-containing protein 2

282 amino acids

May play a role in targeting proteins for ubiquitination and subsequent proteasomal degradation.

Belongs to the CUEDC2 family.

31.712 kDa

MDLQKIIHDALYDFILSYIPHADLSTLDDVILSYITGVLEDLGSQESVEENFDVEVFVEMLEAYIPGFSDIDSVKVCEMMFNLAAKLTSARDTESGEMKIEEGKFPLSESCDLSLGGSREKTHNLTLQAEGATAQVSESSWDNQEQHLLEMFPKCSVTEARSALSIAKGDMEEAVRLIIEGDVQLKCPPSLSANQGKTVSAEVDQKLKASILEKYMLVDDEEDKKVHRPVTPKDAPKKMVRYHGSQVVTTKGERYHLVKKEEPEDMKKTYVSLKPARKYRFH

Cuedc2

CUE domain-containing protein 2

267 amino acids

Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation.

Belongs to the CUEDC2 family.

30.282 kDa

MELERIVSSALFAFVQTHLPEADLSGLDEVIFSYVLGVLEDLGPSGPSEENFDMEAFIEMMEAYVPGFAHIHRGIIEDMVQTLSVQLSSARNKETLRRPEKLKEESRPPAATGNTQDEAAAAEEEQPGVDVLLEVFPTCSMEQAQWVLAKARGNLEEAVQMLIEGKEEGPPGWGGPNQDLPRRLRGPRKEELKSFILQKYMMVDRAEDQKTHRPMAPKEAPKKLIRYIDNQVVSTKGERFKDVRNPETEEMKATYINLKPARKYRFH

Cuedc2

CUE domain-containing protein 2

267 amino acids

Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation.

Belongs to the CUEDC2 family.

30.282 kDa

MELERIVSSALFAFVQTHLPEADLSGLDEVIFSYVLGVLEDLGPSGPSEENFDMEAFIEMMEAYVPGFAHIHRGIIEDMVQTLSVQLSSARNKETLRRPEKLKEESRPPAATGNTQDEAAAAEEEQPGVDVLLEVFPTCSMEQAQWVLAKARGNLEEAVQMLIEGKEEGPPGWGGPNQDLPRRLRGPRKEELKSFILQKYMMVDRAEDQKTHRPMAPKEAPKKLIRYIDNQVVSTKGERFKDVRNPETEEMKATYINLKPARKYRFH