CTSD

Gene

CTSD

Protein

Probable aspartic-type endopeptidase CTSD

Organism

Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)

Length

509 amino acids

Function

Probable GPI-anchored aspartic-type endopeptidase which contributes to virulence.

Similarity

Belongs to the peptidase A1 family.

Mass

54.651 kDa

Sequence

MQFLWLCLLSAVTLQFTGTLAFYPIKLPDFTKGIISHHGSVGRRFFTFPGLYKHAHTGSTTLNIRRGPSNYRRDNNYPAQIASPPTAPNTLGINNDGYDFSYFSEVKVGSEGQKMWMLIDTGASGTWVFGSDCTSKACGRHNTFGKEDSKTIKVTDEKWGVTYGTGKVSGVIVNDTMSFAGFELVTPFGSASTASDDFLNYPMDGILGIGPQDPNAKTPTVVQLLMQQKLLKSNVIGINLQRASEGATDGQITFGDIDKSKFSGELIYSNVVPNGYQWEIAMDDLIMDGKSLNLKGRTGIIDTGTSFLILPPADADLIHSMIPQADKGSGFYTLPCSTKVDIKLSIGGVEYTIQPDDYVGNETATKGTCNSLIVGRQILGPKQWLVGDVFLKNVYSVFDFDKNRVGLAARKYAGTKNPPSSTPSPGMFLLHAIHCQKTISVLMLHIDPTSNKAPSGGSPGLPAESGSDSTTNGEATNGATSSPNSSSSVLTPTWLTLAVFFAIGSSLWS

Protein

Probable aspartic-type endopeptidase CTSD: CTSD

Gene

CTSD

Protein

Probable aspartic-type endopeptidase CTSD

Organism

Trichophyton verrucosum (strain HKI 0517)

Length

509 amino acids

Function

Probable GPI-anchored aspartic-type endopeptidase which contributes to virulence.

Similarity

Belongs to the peptidase A1 family.

Mass

54.631 kDa

Sequence

MQFLWLCLLSAVTLQFTGTLAFYPIKLPDFTKGLVSNHGSIDRRFFTFPGLYKHAHTGSTTLNIRRGPSNYRRDNNYPAQIASPPTAPNTLGINNDGYDFSYFSEVKVGSEGQKMWMLIDTGASGTWVFGSDCTSKACGRHNTFGKEDSKTIKVTDEKWGVTYGTGKVSGVIVNDTMSFAGFELVTPFGSASTASDDFLNYPMDGILGIGPQDPNAKTPTVVQLLMQQKLLKSNVIGINLQRASEGATDGQITFGDIDKSKFSGELIYSNVVPDGYQWEIAMDDLIMDGKSLNLKGRTGIIDTGTSFLILPPADADLIHSMIPQANKGSGFYTLPCSTKVDIKLSIGGVEYTIQPDDYVGNETATKGTCNSLIVGRQILGPKQWLVGDVFLKNVYSVFDFDKNRVGLAARKYAGTKNPPSSTPSPGMFLLHAILCPKTISVLMLHIDPTSNKAPSGGSPGLPAESGSDSTTNGEATNGATSSPNSSSSVLTPTWLTLAVFFAIGSSLWS

Protein

Probable aspartic-type endopeptidase CTSD: CTSD

Gene

ctsD

Protein

Aspartic-type endopeptidase ctsD

Organism

Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)

Length

474 amino acids

Function

Secreted aspartic-type endopeptidase which is secreted and contributes to virulence.

Similarity

Belongs to the peptidase A1 family.

Mass

50.548 kDa

Sequence

MHLLQCLLSTISLASTVTAFVPYSFNLEVSTEGPPSNDVARRFVPWKLLLDDSYNNHGSSSNGVSLTLDLKKFPVRRDNKYKVVLADEPTTPNTAALNQEGLDYSYFATVRVGSQGQQMWLVLDTGGPNTWVFGSDCTTVACQRHETFGEAASKSLKLLPLNWAVGYGTGLVSGVLGTDSLSLAGLDVNMTFGLAKNASTDFESYPVDGILGLGRSANSNFNTPSFMETVATQRLLKSNIIGFSFSRNSDGARDGAANFGDLDTTRFTGDIVYTNTTGDSNNWRIPLDDASVNGTPCRFVNKTAVIDTGTSYAMLPPKDATVLHNLIPGAVTTSHGQNFTLPCNSTAVVQVSFSGLSYNISPKDYVGPAYGSACLSTIVGQALYGDDVWLLGDVFLKNVYSVFDYDNHRIGFANRSVPIASPTTTVAAAANPSATDGAGSTLTGSMAVHTGSASIVSRFVHWPFIFALLCMVLV

Protein

Aspartic-type endopeptidase ctsD: ctsD

Gene

CTSD

Protein

Cathepsin D

Organism

Homo sapiens

Length

412 amino acids

Function

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.

Similarity

Belongs to the peptidase A1 family.

Mass

44.552 kDa

Sequence

MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL

Protein

Cathepsin D: CTSD

Gene

CTSD

Protein

Cathepsin D

Organism

Canis lupus familiaris

Length

410 amino acids

Function

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.

Similarity

Belongs to the peptidase A1 family.

Mass

44.32 kDa

Sequence

MQPPSLLLLVLGLLAAPAAALVRIPLHKFTSVRRTMTELGGPVEDLIAKGPISKYAQGAPAVTGGPIPEMLRNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSGKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCKSALSGLAGIKVERQTFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVEKNIFSFYLNRDPNAQPGGELMLGGTDSKYYKGPLSYLNVTRKAYWQVHMEQVDVGSSLTLCKGGCEAIVDTGTSLIVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPDVTLKLGGKLYKLSSEDYTLKVSQGGKTICLSGFMGMDIPPPGGPLWILGDVFIGCYYTVFDRDQNRVGLAQATRL

Protein

Cathepsin D: CTSD

Gene

CTSD

Protein

Cathepsin D

Organism

Canis lupus familiaris

Length

410 amino acids

Function

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.

Similarity

Belongs to the peptidase A1 family.

Mass

44.32 kDa

Sequence

Protein

Cathepsin D: CTSD

Gene

Ctsd

Protein

Cathepsin D

Organism

Mus musculus

Length

410 amino acids

Function

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.

Similarity

Belongs to the peptidase A1 family.

Mass

44.954 kDa

Sequence

MKTPGVLLLILGLLASSSFAIIRIPLRKFTSIRRTMTEVGGSVEDLILKGPITKYSMQSSPKTTEPVSELLKNYLDAQYYGDIGIGTPPQCFTVVFDTGSSNLWVPSIHCKILDIACWVHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCKSDQSKARGIKVEKQIFGEATKQPGIVFVAAKFDGILGMGYPHISVNNVLPVFDNLMQQKLVDKNIFSFYLNRDPEGQPGGELMLGGTDSKYYHGELSYLNVTRKAYWQVHMDQLEVGNELTLCKGGCEAIVDTGTSLLVGPVEEVKELQKAIGAVPLIQGEYMIPCEKVSSLPTVYLKLGGKNYELHPDKYILKVSQGGKTICLSGFMGMDIPPPSGPLWILGDVFIGSYYTVFDRDNNRVGFANAVVL

Protein

Cathepsin D: Ctsd

Gene

Ctsd

Protein

Cathepsin D

Organism

Rattus norvegicus

Length

407 amino acids

Function

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.

Similarity

Belongs to the peptidase A1 family.

Mass

44.681 kDa

Sequence

MQTPGVLLLILGLLDASSSALIRIPLRKFTSIRRTMTEVGGSVEDLILKGPITKYSMQSSPRTKEPVSELLKNYLDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWVHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCKSDLGGIKVEKQIFGEATKQPGVVFIAAKFDGILGMGYPFISVNKVLPVFDNLMKQKLVEKNIFSFYLNRDPTGQPGGELMLGGTDSRYYHGELSYLNVTRKAYWQVHMDQLEVGSELTLCKGGCEAIVDTGTSLLVGPVDEVKELQKAIGAVPLIQGEYMIPCEKVSSLPIITFKLGGQNYELHPEKYILKVSQAGKTICLSGFMGMDIPPPSGPLWILGDVFIGCYYTVFDREYNRVGFAKAATL

Protein

Cathepsin D: Ctsd

Gene

CTSD

Protein

Cathepsin D

Organism

Gallus gallus

Length

398 amino acids

Function

Acid protease active in intracellular protein breakdown. In chicken it is a key enzyme for yolk formation as it is capable of catalyzing intra oocytic break down of protein components of both vitellogenin and VLDL.

Similarity

Belongs to the peptidase A1 family.

Mass

43.298 kDa

Sequence

MAPRGLLVLLLLALVGPCAALIRIPLTKFTSTRRMLTEVGSEIPDMNAITQFLKFKLGFADLAEPTPEILKNYMDAQYYGEIGIGTPPQKFTVVFDTGSSNLWVPSVHCHLLDIACLLHHKYDASKSSTYVENGTEFAIHYGTGSLSGFLSQDTVTLGNLKIKNQIFGEAVKQPGITFIAAKFDGILGMAFPRISVDKVTPFFDNVMQQKLIEKNIFSFYLNRDPTAQPGGELLLGGTDPKYYSGDFSWVNVTRKAYWQVHMDSVDVANGLTLCKGGCEAIVDTGTSLITGPTKEVKELQTAIGAKPLIKGQYVISCDKISSLPVVTLMLGGKPYQLTGEQYVFKVSAQGETICLSGFSGLDVPPPGGPLWILGDVFIGPYYTVFDRDNDSVGFAKCV

Protein

Cathepsin D: CTSD

Gene

CTSD

Protein

Cathepsin D

Organism

Gallus gallus

Length

398 amino acids

Function

Similarity

Belongs to the peptidase A1 family.

Mass

43.298 kDa

Sequence

Protein

Cathepsin D: CTSD

Gene

ctsd

Protein

Cathepsin D

Organism

Chionodraco hamatus

Length

396 amino acids

Function

Acid protease active in intracellular protein breakdown.

Similarity

Belongs to the peptidase A1 family.

Mass

42.958 kDa

Sequence

MKMLLLCVFSALALTNDALVRIPLKKFRSIRRQLTDSGKRAEELLADHHSLKYNLSFPASNAPTPETLKNYLDAQYYGEIGLGTPPQPFTVVFDTGSSNLWVPSIHCSLLDIACLLHHKYNSGKSSTYVKNGTAFAIQYGSGSLSGYLSQDTCTIGDLAIDSQLFGEAIKQPGVAFIAAKFDGILGMAYPRISVDGVAPVFDNIMSQKKVEQNVFSFYLNRNPDTEPGGELLLGGTDPKYYTGDFNYVNVTRQAYWQIRVDSMAVGDQLSLCTGGCEAIVDSGTSLITGPSVEVKALQKAIGAFPLIQGEYMVNCDTVPSLPVISFTVGGQVYTLTGEQYILKVTQAGKTMCLSGFMGLDIPAPAGPLWILGDVFMGQYYTVFDRDANRVGFAKAK

Protein

Cathepsin D: ctsd

Gene

ctsd

Protein

Cathepsin D

Organism

Clupea harengus

Length

396 amino acids

Function

Acid protease active in intracellular protein breakdown.

Similarity

Belongs to the peptidase A1 family.

Mass

43.316 kDa

Sequence

MKFLYLFLFAVFAWTSDAIVRIPLKKFRSIRRTLSDSGLNVEQLLAGTNSLQHNQGFPSSNAPTPETLKNYMDAQYYGEIGLGTPVQMFTVVFDTGSSNLWLPSIHCSFTDIACLLHHKYNGAKSSTYVKNGTEFAIQYGSGSLSGYLSQDSCTIGDIVVEKQLFGEAIKQPGVAFIAAKFDGILGMAYPRISVDGVPPVFDMMMSQKKVEQNVFSFYLNRNPDTEPGGELLLGGTDPKYYTGDFNYVPVTRQAYWQIHMDGMSIGSQLTLCKDGCEAIVDTGTSLITGPPAEVRALQKAIGAIPLIQGEYMIDCKKVPTLPTISFNVGGKTYSLTGEQYVLKESQGGKTICLSGLMGLEIPPPAGPLWILGDVFIGQYYTVFDRESNRVGFAKST

Protein

Cathepsin D: ctsd

Gene

ctsd

Protein

Cathepsin D

Organism

Chionodraco hamatus

Length

396 amino acids

Function

Acid protease active in intracellular protein breakdown.

Similarity

Belongs to the peptidase A1 family.

Mass

42.958 kDa

Sequence

Protein

Cathepsin D: ctsd

Gene

ctsd

Protein

Cathepsin D

Organism

Clupea harengus

Length

396 amino acids

Function

Acid protease active in intracellular protein breakdown.

Similarity

Belongs to the peptidase A1 family.

Mass

43.316 kDa

Sequence

Protein

Cathepsin D: ctsd

Gene

CTSD

Protein

Cathepsin D

Organism

Bos taurus

Length

390 amino acids

Function

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.

Similarity

Belongs to the peptidase A1 family.

Mass

42.491 kDa

Sequence

VIRIPLHKFTSIRRTMSEAAGXVXXLIAKGPISKYATGEPAVRQGPIPELLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSANLWVPSIHCKLLDIACWTHRKYNSDKSSTYVKNGTTFDIHYGSGSLSGYLSQDTVSVPCNPSSSSPGGVTVQRQTFGEAIKQPGVVFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDKNVFSFFLNRDPKAQPGGELMLGGTDSKYYRGSLMFHNVTRQAYWQIHMDQLDVGSSLTVCKGGCEAIVDTGTSLIVGPVEEVRELQKAIGAVPLIQGEYMIPCEKVSSLPEVTVKLGGKDYALSPEDYALKVSQAETTVCLSGFMGMDIPPPGGPLWILGDVFIGRYYTVFDRDQNRVGLAEAARL

Protein

Cathepsin D: CTSD

Gene

CTSD

Protein

Cathepsin D

Organism

Bos taurus

Length

390 amino acids

Function

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.

Similarity

Belongs to the peptidase A1 family.

Mass

42.491 kDa

Sequence

Protein

Cathepsin D: CTSD

Gene

ctsD

Protein

Cathepsin D

Organism

Dictyostelium discoideum

Length

383 amino acids

Function

Protease that may act during cell growth and/or development.

Similarity

Belongs to the peptidase A1 family.

Mass

41.121 kDa

Sequence

MKLLILTLFLATIVLAQALTVPLNFHQASRESRRRVPQKWSNRLSALNAGTTIPISDFEDAQYYGAITIGTPGQAFKVVFDTGSSNLWIPSKKCPITVVACDLHNKYNSGASSTYVANGTDFTIQYGSGAMSGFVSQDSVTVGSLTVKDQLFAEATAEPGIAFDFAKFDGILGLAFQSISVNSIPPVFYNMLSQGLVSSTLFSFWLSRTPGANGGELSFGSIDNTKYTGDITYVPLTNETYWEFVMDDFAIDGQSAGFCGTTCHAICDSGTSLIAGPMADITALNEKLGAVILNGEGVFSDCSVINTLPNVTITVAGREFVLTPKEYVLEVTEFGKTECLSGFMGIELNMGNFWILGDVFISAYYTVFDFGNKQVGFATAIQG

Protein

Cathepsin D: ctsD

Gene

CTSD

Protein

Probable aspartic-type endopeptidase CTSD

Organism

Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)

Length

377 amino acids

Function

Secreted aspartic-type endopeptidase which is secreted and contributes to virulence.

Similarity

Belongs to the peptidase A1 family.

Mass

39.731 kDa

Fragment

single

Sequence

SLIDTGASRTWVFGSDCTSKSCGAHNTFGKEDSKTIKVTDEKWDVAYGTGKVAGVIVNDTMSFAGFELDTPFGSATTASDDFMSYPMDGILGIGPQDSKAKVPTVIQLLMQQKLLKSNIIGINLQRNSDGATDGQITFGDVDKSKFSGELAYSNVVSGGYQWEIAVDDIIVDGKPLNFQGRSGIVDTGTSFLLLPPDDADLIHSKIPKSAKSSVFYTVPCSTTTNIELSISGVKYAIKPKDYVGYESTTKGICNSLIIGRQAIGPKQWLLGDVFLKNVYSVYDFDKNRVGLAARKYGETKDPPSSSHPPPAPTSNKASGGSPGLPEQSGTSSATTSTTGEPSSGSTASPSAASSVSMSAWLSLAVFLSTASSLILWD

Protein

Probable aspartic-type endopeptidase CTSD: CTSD

Gene

CTSD

Protein

Cathepsin D

Organism

Ovis aries

Length

365 amino acids

Function

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.

Similarity

Belongs to the peptidase A1 family.

Mass

39.815 kDa

Fragment

single

Sequence

LHKFTSNRRTMSEAMGPVEHLIAKGPISKYATREPAVRQGPIPELLTNYMDAQYYGEIGIGTPPQCFTVVFDTGSANLWVPSIHCKLLDIACWVHHKYNSDKSSTYVKNGTTFDIHYGSGSLSGYLSQDTVSVPCNPSSSSPGGVTVQRQTFGEAIKQPGVVFIAAKFDGILGMAYPRISVNNVLPVFDNLMRQKLVDKNVFSFFLNRDPKAQPGEELMLGGTDSKYYRGSLTYHNVTRQAYWQIHMDQLDVGSSLTVCKGGCEAIVDTGTSLMVGPVDEVRELHKAIGAVPLIQGEYMIPCEKVSSLPQVTLKLGGKDYTLSPEDYTLKVSQAGTTVCLSGFMGMDIPPPGGPLWILGDVFIGR

Protein

Cathepsin D: CTSD

Gene

CTSD

Protein

Cathepsin D

Organism

Sus scrofa

Length

345 amino acids

Function

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.

Similarity

Belongs to the peptidase A1 family.

Mass

37.295 kDa

Sequence

GPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSGKSSTYVKNGTTFAIHYGSGSLSGYLSSQDTVSVPCNSALSGVGGIKVERQTFGEATKQPGLTFIAAKFDGILGMAYPRISVNNVVPVFDNLMQQKLVDKDIFSFYLNRDPGAQPGGELMLGGIDSKYYKGSLDYHNVTRKAYWQIHMNQVAVGSSLTLCKGGCEAIVDTGTSLIVGQPEEVRELGKAIGAVPLIQGEYMIPCEKVPSLPDVTVTLGGKKYKLSSENYTLKVSQAGQTICLSGFMGMDIPPPGGPLWILGDVFIGRYYTVFDRDLNRVGLAEAA

Protein

Cathepsin D: CTSD