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CSN2

Gene
csn2
Protein
COP9 signalosome complex subunit 2
Organism
Dictyostelium discoideum
Length
449 amino acids
Function
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity.
Similarity
Belongs to the CSN2 family.
Mass
52.11 kDa
Sequence
MSDDEDMMYDDDEYFDDDEDQDQNDSESEGVEIENQYYNSKGLIDESIPDAIKSYEKVVDLENGEKGEWGFKALKKITKLYFRIGDFDNMLESFKKFLPYTKSSASSNYIEKGINSVLDMVSSSNTIELDMIQKVFDLTLKSLLDTKNERVWFRTNLKLAKLLFEKAEYGRLAKILRDLHKSCELEDGTDDQKKGSQLVDIYALEIQMYTETKNNKKLKDLYKKALEIKSAIPHPRIMGIIRECGGKMHMAEKEWEKAHTDFFEAFKNYDEAGNSRRIQCLKYLVLACMLMLSTINPFDSTEAKPYKNDPDILAMTNLVMAYEKNDIYAFEKILKDNRKTIMDDPFIRMYIEDLLRNIRTQVLLKLLKPYTRIRISFISKELNIPSSDVESLLVSLILDNKIRGSIDQVNQQLELDTAKSSAYWKYTSIHKWANQIGQLNGGINNKLVS

Gene
csn2
Protein
COP9 signalosome complex subunit 2
Organism
Xenopus laevis
Length
441 amino acids
Function
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
Similarity
Belongs to the CSN2 family.
Mass
51.336 kDa
Fragment
single
Sequence
DMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKINFKLGNYPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYISTSKQMDLLQEFYETTLDALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILRQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA

Gene
CSN2
Protein
COP9 signalosome complex subunit 2
Organism
Arabidopsis thaliana
Length
439 amino acids
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of IAA6 by regulating the activity of the Ubl ligase SCF-TIR complex.
Similarity
Belongs to the CSN2 family.
Mass
51.186 kDa
Sequence
MASDADMEDYGFEYSDEEQEEQDVDIENQYYNSKGMVETEPEEALSGFAEVVQMEPEKADWGFKALKQTVKIYYRLGKYKEMMEAYTEMLTYIKSAVTRNYSEKCINNIMDFVSGSASQNTGLLQEFYQTTLKALEEAKNERLWFKTNLKLCNIWFDIGEYRRMTKILKELHKSCQKEDGTDDQKKGSQLLEVYAIEIQIYTETKDNKKLKQLYHKALAIKSAIPHPRIMGIIRECGGKMHMAERQWEEAATDFFEAFKNYDEAGNQRRIQCLKYLVLANMLMESEVNPFDGQEAKPYKNDPEILAMTNLIAAYQRNEIIEFERILKSNRRTIMDDPFIRNYMEDLLKKVRTQVLLKLIKPYTKIGIPFISKELNVPETDVTELLVSLILDSRIDGHIDEMNRYLLRGDSGNGRKLHKAVDKWNSQLKSLSSNITSRVC

Gene
csn2
Protein
COP9 signalosome complex subunit 2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
437 amino acids
Function
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). Required, indirectly, for activation of ribonucleotide reductase through the degradation of the protein spd1, thereby supplying deoxyribonucleotides for DNA replication and repair.
Similarity
Belongs to the CSN2 family.
Mass
51.375 kDa
Sequence
MSNDFMLEDDENYDFEFEDDDDDMIEPYVDVENCYYNSKSLKEENPESALTSFYSIVEKCEGEQNEWAFKALKQITKINFQLKKYDDMLQSYQRLLGYTNWLSITKNYSEKSIYNIVEYASSCENTEFLEKFYDVTTKALQNLNNERLMLKVLMHVARFLLTQKNYHKFKYLLRQMHELLSDENNSVADQNRGTHLLELYSLEIQMYSDIEDNKRLKELYQSSLRVKTAIPHPRIMGIIRECGGKMHMQENQWSEAQTNFFESFKSYDEAGSSDRIRVLKYLVLANMLSESEINPFDSPETQPYKDNPHIIAMTKLVEAYQIRDITAVERILQTYQHDILDDDFIRQYVDKILYSIRSQVLIELVKPYTSVKLSLLAKKLGVSISIIEQALVGLIIDERVNGKIDMVNEVFTISQPKNTIHNQLVEDVQKLWNTATK

Gene
CSN2
Protein
Beta-casein
Organism
Macropus eugenii
Length
302 amino acids
Function
Important role in determination of the surface properties of the casein micelles.
Similarity
Belongs to the beta-casein family.
Mass
35.882 kDa
Sequence
MKLLILTCLVALGFARPMVEKISESEEYVNEVPEKRLKRRFPVKNEHQVEINHHLRPESEMMSLYYQPFYWSEEMRNLKMTSLPKDRRMAVLKSTVSDEVFPSLQHKSLSLPKSKVQPLSRQQILTFHTLQMVPLSHKLLTTPKREMLPIYERERLPAHKRESLLAHERESLLAHERDILVPQREMSFVPEREFLFASERVVLPEQEKEILHNDEREVLAVHKKEILPPFEKEKVLPLLQHRVVPLPQREIVPPFQRETLLPEEILPVNQWELMPEVVPFDPYPFLQPVAPFYYSTELNEKN

Gene
CSN2
Protein
Beta-casein
Organism
Trichosurus vulpecula
Length
285 amino acids
Function
Important role in determination of the surface properties of the casein micelles.
Similarity
Belongs to the beta-casein family.
Mass
33.802 kDa
Sequence
MKLLILTCLVVLAVARPMVEKISESEEHVTDVPENEHRLEINRYLRPEYEMMNLYYQPFYWSEEMRNLKMTSLPKDRRMAVLKSVVSDDMLPPLQHKSLSLPKPKVLPLSHRQILPPHTLRMVPLSHKLFTIPKREMLPISERERLPAHERENLLAHEREILLAPQREMSLIPEREILLAAERVVLPEQEREIRPDNEREVLAVHKREILPASEKEKVLPLFQERVLPLHRREIVPPYQRDTIARREILPVDQRELMPEVVAVDLYPFFQPVANFYYPAELNEKN

Gene
CSN2
Protein
Beta-casein
Organism
Equus caballus
Length
241 amino acids
Function
Important role in determination of the surface properties of the casein micelles.
Similarity
Belongs to the beta-casein family.
Mass
27.049 kDa
Sequence
MKILILACLVALALAREKEELNVSSETVESLSSNEPDSSSEESITHINKEKLQKFKHEGQQQREVERQDKISRFVQPQPVVYPYAEPVPYAVVPQSILPLAQPPILPFLQPEIMEVSQAKETILPKRKVMPFLKSPIVPFSERQILNPTNGENLRLPVHLIQPFMHQVPQSLLQTLMLPSQPVLSPPQSKVAPFPQPVVPYPQRDTPVQAFLLYQDPRLGPTGELDPATQPIVAVHNPVIV

Gene
CSN2
Protein
Beta-casein
Organism
Camelus dromedarius
Length
232 amino acids
Function
Important role in determination of the surface properties of the casein micelles.
Similarity
Belongs to the beta-casein family.
Mass
26.218 kDa
Sequence
MKVLILACRVALALAREKEEFKTAGEALESISSSEESITHINKQKIEKFKIEEQQQTEDEQQDKIYTFPQPQSLVYSHTEPIPYPILPQNFLPPLQPAVMVPFLQPKVMDVPKTKETIIPKRKEMPLLQSPVVPFTESQSLTLTDLENLHLPLPLLQSLMYQIPQPVPQTPMIPPQSLLSLSQFKVLPVPQQMVPYPQRAMPVQAVLPFQEPVPDPVRGLHPVPQPLVPVIA

Gene
CSN2
Protein
Beta-casein
Organism
Sus scrofa
Length
232 amino acids
Function
Important role in determination of the surface properties of the casein micelles.
Similarity
Belongs to the beta-casein family.
Mass
25.949 kDa
Sequence
MKLLILACFVALALARAKEELNASGETVESLSSSEESITHISKEKIEKLKREEQQQTENERQNKIHQFPQPQPLAHPYTEPIPYPILPQNILPLAQVPVVVPLLHPEVMKDSKAKETIVPKRKGMPFPKSPAEPFVEGQSLTLTDFEVLSLPLLQSLMHQIPQPVPQTPMFAPQPLLSLPQAKVLPVPQQVVPFPQRDMPFQALLLYQDPLLGPLQGFYPVPQPVAPVYNPV

Gene
Csn2
Protein
Beta-casein
Organism
Mus musculus
Length
231 amino acids
Function
Important role in determination of the surface properties of the casein micelles.
Similarity
Belongs to the beta-casein family.
Mass
25.337 kDa
Sequence
MKVFILACLVALALARETTFTVSSETDSISSEESVEHINEQKLQKVNLMGQLQAEDVLQAKVHSSIQSQPQAFPYAQAQTISCNPVPQNIQPIAQPPVVPSLGPVISPELESFLKAKATILPKHKQMPLLNSETVLRLINSQIPSLASLANLHLPQSLVQLLAQVVQAFPQTHLVSSQTQLSLPQSKVLYFLQQVAPFLPQDMSVQDLLQYLELLNPTVQFPATPQHSVSV

Gene
Csn2
Protein
Beta-casein
Organism
Rattus norvegicus
Length
231 amino acids
Function
Important role in determination of the surface properties of the casein micelles.
Similarity
Belongs to the beta-casein family.
Mass
25.369 kDa
Sequence
MKVFILACLVALALAREKDAFTVSSETGSISSEESVEHINEKLQKVKLMGQVQSEDVLQNKFHSGIQSEPQAIPYAQTISCSPIPQNIQPIAQPPVVPTVGPIISPELESFLKAKATVLPKHKQMPFLNSETVLRLFNSQIPSLDLANLHLPQSPAQLQAQIVQAFPQTPAVVSSQPQLSHPQSKSQYLVQQLAPLFQQGMPVQDLLQYLDLLLNPTLQFLATQQLHSTSV

Gene
CSN2
Protein
Beta-casein
Organism
Oryctolagus cuniculus
Length
228 amino acids
Function
Important role in determination of the surface properties of the casein micelles.
Similarity
Belongs to the beta-casein family.
Mass
26.072 kDa
Sequence
MKVLILACLVALALAREKEQLSVPTEAVGSVSSSEEITHINKQKLETIKHVEQLLREEKLQDKILPFIQSLFPFAERIPYPTLPQNILNLAQLDMLLPLLQPEIMEDPKAKETIIPKHKLMPFLKSPKTVPFVDSQILNLREMKNQHLLLPQLLPFMHQVFQPFPQTPIPYPQALLSLPQSKFMPIVPQVVPYPQRDMPIQALQLFQELLFPTHQGYPVVQPIAPVNV

Gene
CSN2
Protein
Beta-casein
Organism
Equus asinus
Length
226 amino acids
Function
Important role in determination of the surface properties of the casein micelles.
Similarity
Belongs to the beta-casein family.
Mass
25.529 kDa
Sequence
REKEELNVSSETVESLSSNEPDSSSEESITHINKEKSQKFKHEGQQQREVEHQDKISRFVQPQPVVYPYAEPVPYAVVPQNILVLAQPPIVPFLQPEIMEVSQAKETILPKRKVMPFLKSPIVPFSERQILNPTNGENLRLPVHLIQPFMHQVPQSLLQTLMLPSQPVLSPPQSKVAPFPQPVVPYPQRDTPVQAFLLYQDPQLGLTGEFDPATQPIVPVHNPVIV

Gene
CSN2
Protein
Beta-casein
Organism
Homo sapiens
Length
226 amino acids
Function
Important role in determination of the surface properties of the casein micelles.
Similarity
Belongs to the beta-casein family.
Mass
25.382 kDa
Sequence
MKVLILACLVALALARETIESLSSSEESITEYKQKVEKVKHEDQQQGEDEHQDKIYPSFQPQPLIYPFVEPIPYGFLPQNILPLAQPAVVLPVPQPEIMEVPKAKDTVYTKGRVMPVLKSPTIPFFDPQIPKLTDLENLHLPLPLLQPLMQQVPQPIPQTLALPPQPLWSVPQPKVLPIPQQVVPYPQRAVPVQALLLNQELLLNPTHQIYPVTQPLAPVHNPISV

Gene
CSN2
Protein
Beta-casein
Organism
Bos taurus
Length
224 amino acids
Function
Antioxidant peptide has antioxidant activity.
Similarity
Belongs to the beta-casein family.
Mass
25.107 kDa
Sequence
MKVLILACLVALALARELEELNVPGEIVESLSSSEESITRINKKIEKFQSEEQQQTEDELQDKIHPFAQTQSLVYPFPGPIPNSLPQNIPPLTQTPVVVPPFLQPEVMGVSKVKEAMAPKHKEMPFPKYPVEPFTESQSLTLTDVENLHLPLPLLQSWMHQPHQPLPPTVMFPPQSVLSLSQSKVLPVPQKAVPYPQRDMPIQAFLLYQEPVLGPVRGPFPIIV

Gene
CSN2
Protein
Beta-casein
Organism
Bubalus bubalis
Length
224 amino acids
Function
Important role in determination of the surface properties of the casein micelles.
Similarity
Belongs to the beta-casein family.
Mass
25.106 kDa
Sequence
MKVLILACLVALALARELEELNVPGEIVESLSSSEESITHINKKIEKFQSEEQQQMEDELQDKIHPFAQTQSLVYPFPGPIPKSLPQNIPPLTQTPVVVPPFLQPEIMGVSKVKEAMAPKHKEMPFPKYPVEPFTESQSLTLTDVENLHLPLPLLQSWMHQPPQPLPPTVMFPPQSVLSLSQSKVLPVPQKAVPYPQRDMPIQAFLLYQEPVLGPVRGPFPIIV

Gene
CSN2
Protein
Beta-casein
Organism
Ovis aries
Length
222 amino acids
Function
Important role in determination of the surface properties of the casein micelles.
Similarity
Belongs to the beta-casein family.
Mass
24.875 kDa
Sequence
MKVLILACLVALALAREQEELNVVGETVESLSSSEESITHINKKIEKFQSEEQQQTEDELQDKIHPFAQAQSLVYPFTGPIPNSLPQNILPLTQTPVVVPPFLQPEIMGVPKVKETMVPKHKEMPFPKYPVEPFTESQSLTLTDVEKLHLPLPLVQSWMHQPPQPLPPTVMFPPQSVLSLSQPKVLPVPQKAVPQRDMPIQAFLLYQEPVLGPVRGPFPILV

Gene
CSN2
Protein
Beta-casein
Organism
Capra hircus
Length
222 amino acids
Function
Important role in determination of the surface properties of the casein micelles.
Similarity
Belongs to the beta-casein family.
Mass
24.865 kDa
Sequence
MKVLILACLVALAIAREQEELNVVGETVESLSSSEESITHINKKIEKFQSEEQQQTEDELQDKIHPFAQAQSLVYPFTGPIPNSLPQNILPLTQTPVVVPPFLQPEIMGVPKVKETMVPKHKEMPFPKYPVEPFTESQSLTLTDVEKLHLPLPLVQSWMHQPPQPLSPTVMFPPQSVLSLSQPKVLPVPQKAVPQRDMPIQAFLLYQEPVLGPVRGPFPILV

Gene
csn2
Protein
CRISPR-associated protein Csn2
Organism
Streptococcus agalactiae (strain ATCC 13813 / DSM 2134 / JCM 5671 / NCIMB 701348 / NCTC 8181)
Length
221 amino acids
Function
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity). Binds dsDNA, binding is disrupted by EGTA.
Similarity
Belongs to the CRISPR-associated Csn2 protein family.
Mass
25.65 kDa
Sequence
MIKINFPILDEPLVLSNATILTIEDVSVYSSLVKHFYQYDVDEHLKLFDDKQKSLKATELMLVTDILGYDVNSAPILKLIHGDLENQFNEKPEVKSMVEKLAATITELIAFECLENELDLEYDEITILELIKVLGVKIETQSDTIFEKCFEIIQVYNYLTKKNLLVFVNSGAYLTKDEVIKLCEYINLMQKSVLFLEPRRLYDLPQYVIDKDYFLIGENMV

Gene
csn2
Protein
CRISPR-associated protein Csn2
Organism
Streptococcus pyogenes serotype M1
Length
220 amino acids
Function
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity). Binds dsDNA, binding is disrupted by EGTA.
Similarity
Belongs to the CRISPR-associated Csn2 protein family.
Mass
25.587 kDa
Sequence
MNLNFSLLDEPIPLRGGTILVLEDVCVFSKIVQYCYQYEEDSELKFFDHKMKTIKESEIMLVTDILGFDVNSSTILKLIHADLESQFNEKPEVKSMIDKLVATITELIVFECLENELDLEYDEITILELIKSLGVKVETQSDTIFEKCLEILQIFKYLTKKKLLIFVNSGAFLTKDEVASLQEYISLTNLTVLFLEPRELYDFPQYILDEDYFLITKNMV

Gene
csn2
Protein
CRISPR-associated protein Csn2
Organism
Enterococcus faecalis
Length
219 amino acids
Function
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity). Binds dsDNA, binding is disrupted by EGTA.
Similarity
Belongs to the CRISPR-associated Csn2 protein family.
Mass
25.407 kDa
Sequence
MRVNFSLLEEPIEIEKATFLTIKDVQSFAHLVKLIYQYDGENELKLFDAQQKGLKPTELFVVTDILGYDVNSAATLKLIYGDLEAQLNDKPEVKSMIEKLTGTISQLIGYELLEHEMDLEEDGIIVQELFKALGIKIETTSDTIFEKVMEITQVHRYLSKKKLLIFINACTYLTEDEVQQVVEYISLNNVDVLFLEQRVVQNRFQYILDENFYLSYEKA

Gene
csn2
Protein
CRISPR-associated protein Csn2
Organism
Streptococcus thermophilus
Length
219 amino acids
Function
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (Probable). Binds dsDNA (By similarity). When the CRISPR3/cas system consisting of cas9-cas1-cas2-csn2-CRISPR3 or just cas9-CRISPR3 is expressed in E.coli it prevents plasmids homologous to spacers 1 or 2 from transforming.
Similarity
Belongs to the CRISPR-associated Csn2 protein family.
Mass
25.513 kDa
Sequence
MKINFSLLDEPMEVNLGTVLVIEDVSVFAQLVKEFYQYDEQSNLTIFDSKIRSIRSSELLLITDILGYDINTSQVLKLLHTDIVSQLNDKPEVRSEIDSLVSLITDIIMAECIENELDIEYDEITLLELIKALGVRIETKSCTVFEKIFEILQIFKYLVKKRILVFVNSLSYFSKDEIYQILEYTKLSQADVLFLEPRQIEGIQQFILDKDYILMPYNN

Gene
CSN2
Protein
COP9 signalosome complex subunit 2
Organism
Brassica oleracea
Length
39 amino acids
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes (By similarity).
Similarity
Belongs to the CSN2 family.
Mass
4.865 kDa
Fragment
multiple
Sequence
KSAVTRNYSEKKNERLWFKKNYDHAGNQRRIQKWNTQLK