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CRP

Gene
crp
Protein
C-reactive protein
Organism
Xenopus laevis
Length
238 amino acids
Function
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis, and complement fixation through its calcium-dependent binding to phosphorylcholine.
Similarity
Belongs to the pentraxin family.
Mass
27.085 kDa
Sequence
MERFALWFIFLAGSLAQEDLVGNVFLFPKPSVTTYAILKPEVEKPLKNLTVCLRSYTTLTRFHSLLSLATSNPLQDNAFLLFSKPPNQCSIYINQEENVFKVDPTAVEWKHTCVSWDSVSGVVELWIDGKLYPRTVSKKASSIGFPSSIIQGQEQDSFGGGFNIDQSFVGEISDVHMWDYVLTPDHIQKVLFANMDFNGNIISWRSLQYELRGQATTQPKRQCKTLEHHYGLFAKCYK

Gene
Crp
Protein
C-reactive protein
Organism
Rattus norvegicus
Length
230 amino acids
Function
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity).
Similarity
Belongs to the pentraxin family.
Mass
25.468 kDa
Sequence
MEKLLWCLLITISFSQAFGHEDMSKQAFVFPGVSATAYVSLEAESKKPLEAFTVCLYAHADVSRSFSIFSYATKTSFNEILLFWTRGQGFSIAVGGPEILFSASEIPEVPTHICATWESATGIVELWLDGKPRVRKSLQKGYIVGTNASIILGQEQDSYGGGFDANQSLVGDIGDVNMWDFVLSPEQINAVYVGRVFSPNVLNWRALKYETHGDVFIKPQLWPLTDCCES

Gene
CRP
Protein
C-reactive protein
Organism
Cavia porcellus
Length
225 amino acids
Function
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity).
Similarity
Belongs to the pentraxin family.
Mass
25.225 kDa
Sequence
MAKLLLYFLLLTSLSDVFGGTDMSKKTFVFPKETDNSYVSLKAQLKKPLSAFTVCLHIYTELFMTRGYSIFSYATEKEANEILIFWSKDRGYILGVGGIEMPFKAPEIPSAPVHICTSWESVSGIIELWVDGKAQVRKSLQKGYFVGTEAMIILGQDQDSFGGSFDANQSFVGDIGDVNMWDFVLSPKEIDMVYSGGTFSPNVLSWRSLTYETHGEVFIKPQLWP

Gene
CRP
Protein
C-reactive protein
Organism
Mesocricetus auratus
Length
225 amino acids
Function
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity).
Similarity
Belongs to the pentraxin family.
Mass
24.822 kDa
Sequence
MEKLLWCSLVMIGFSQAFAQKDMSKTAFVFPKESANSYVSLEAQSKKTLKAFTVCLHIFTELSTTRSFSIFSYATKNSPNEILIFWSKDRGYAFGVGGPEVLFKASEIPEVPTHICASWESATGIAELWVDGKPKVRKILQKGYTVGTDASIILGQEQDSYGGGFDANQSLVGDIGDVNMWDIVLSPEQINTVCVGGTLDPSVLNWQALKYKVQGDVFIKPQLWP

Gene
Crp
Protein
C-reactive protein
Organism
Mus musculus
Length
225 amino acids
Function
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
Similarity
Belongs to the pentraxin family.
Mass
25.36 kDa
Sequence
MEKLLWCLLIMISFSRTFGHEDMFKKAFVFPKESDTSYVSLEAESKKPLNTFTVCLHFYTALSTVRSFSVFSYATKKNSNDILIFWNKDKQYTFGVGGAEVRFMVSEIPEAPTHICASWESATGIVEFWIDGKPKVRKSLHKGYTVGPDASIILGQEQDSYGGDFDAKQSLVGDIGDVNMWDFVLSPEQISTVYVGGTLSPNVLNWRALNYKAQGDVFIKPQLWS

Gene
CRP
Protein
C-reactive protein
Organism
Oryctolagus cuniculus
Length
225 amino acids
Function
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity).
Similarity
Belongs to the pentraxin family.
Mass
25.493 kDa
Sequence
MEKLLWCFLTLVSFSNMSDQAGMHKKAFVFPKESDNSYVSLNAQLKKPLKAFTVCLYFYTDLSMTRGYSIFSYATRRQFNEILLFWSKDIGYSFSVGGDEIIFKVSDIPVDPTHLCASWESSTGIAELWVDGKPMVRKSLKKGYILGPEASIILGQDQDSFGGSFEKQQSLVGDIGNVNMWDYALSPEEINTIYAGGTFSPNVLDWRELTYQVRGEVHVKPQLWP

Gene
crp
Protein
cAMP-activated global transcriptional regulator CRP
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Length
224 amino acids
Function
A global transcription regulator required for bacterial competence. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT-3') to regulate transcription at 54 promoters (PubMed:15769466). There are 2 consensus subclasses; CRP-N (above) and CRP-S (T6 changed to C and A17 changed to G) which obligatorily also requires Sxy for expression. CRP-S sites bind DNA but do not activate transcription in the absence of Sxy. Probably induces a severe bend in DNA. Probably acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.
Mass
25.152 kDa
Sequence
MSNELTEIDEVVTSSQEEATQRDPVLDWFLTHCHLHKYPAKSTLIHAGEDATTLYYVIKGSVMVSSKDDEGKEMILTYLGAGQFFGEAGLFDEGSKRSAWVKTKTTCEIAEISYKKYRQLIQANPEILMFLTAQLARRLQNTSRQVTNLAFLDVAGRIAQTLMNLAKQPEAMTHPDGMQIKITRQEIGQMVGCSRETVGRIIKMLEDQNLIHAHGKTIVVYGAR

Gene
CRP
Protein
C-reactive protein
Organism
Homo sapiens
Length
224 amino acids
Function
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
Similarity
Belongs to the pentraxin family.
Mass
25.039 kDa
Sequence
MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWESASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP

Gene
crp
Protein
CRP-like cAMP-activated global transcriptional regulator
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
224 amino acids
Function
Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. Activates expression of whiB1.
Mass
24.791 kDa
Sequence
MDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR

Gene
crp
Protein
CRP-like cAMP-activated global transcriptional regulator
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
224 amino acids
Function
Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. The CRP regulon is predicted to contain about 115 genes. Some genes are activated by CRP (rpfA, whiB1) while others are repressed (fadD10). There are 2 CRP-binding sites in the promoter of whiB1, at low concentrations of CRP with or without cAMP transcription of whiB1 is enhanced via site CRP1, then repressed as site CRP2 is filled.
Mass
24.791 kDa
Sequence
MDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR

Gene
CRP
Protein
C-reactive protein
Organism
Sus scrofa
Length
222 amino acids
Function
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity).
Similarity
Belongs to the pentraxin family.
Mass
24.925 kDa
Sequence
MEKLSLCLLVIISLSNAFAQTDMIGKAFVFPKESENSYVSLTARLTKPLTAFTVCLRVYTDLNRDYSLFSYATKTQYNEILLFRGKTAVYSISVGGADVVFKPHQSSEPMHFCMTWESTSGITELWVDGKPMVRRSLKRGYSLGTQASIILGQEQDAFAGGFEKNQCLVGDIGDVNMWDYVLSPEEINTVYAGGTFSPNVLNWRALRYEMSGEVYVKPQLWP

Gene
crp
Protein
cAMP-activated global transcriptional regulator CRP
Organism
Escherichia coli O157:H7
Length
210 amino acids
Function
A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity).
Mass
23.64 kDa
Sequence
MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR

Gene
crp
Protein
cAMP-activated global transcriptional regulator CRP
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Length
210 amino acids
Function
A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity).
Mass
23.64 kDa
Sequence
MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR

Gene
crp
Protein
cAMP-activated global transcriptional regulator CRP
Organism
Escherichia coli (strain K12)
Length
210 amino acids
Function
A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT-3') to directly regulate the transcription of about 300 genes in about 200 operons and indirectly regulate the expression of about half the genome. There are 3 classes of CRP promoters; class I promoters have a single CRP-binding site upstream of the RNA polymerase (RNAP)-binding site, whereas in class II promoters the single CRP- and RNAP-binding site overlap, CRP making multiple contacts with RNAP. Class III promoters require multiple activator molecules, including at least one CRP dimer. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA (about 87 degrees), bringing upstream promoter elements into contact with RNAP. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. High levels of active CRP are detrimental to growth (PubMed:16260780). Plays a major role in carbon catabolite repression (CCR). CCR involves cAMP, adenylate cyclase (cyaA), CRP and the EIIA-Glc component of the PTS (crr). In the presence of glucose EIIA-Glc is dephosphorylated, and does not activate adenylate cyclase, leading to reduced cAMP and thus decreased CRP activity. Also plays a role in many other processes (see PubMed:22573269).
Mass
23.64 kDa
Sequence
MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR

Gene
crp
Protein
cAMP-activated global transcriptional regulator CRP
Organism
Klebsiella aerogenes
Length
210 amino acids
Function
A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity).
Mass
23.656 kDa
Sequence
MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSSQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR

Gene
crp
Protein
cAMP-activated global transcriptional regulator CRP
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
210 amino acids
Function
A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity).
Mass
23.656 kDa
Sequence
MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSSQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR

Gene
crp
Protein
cAMP-activated global transcriptional regulator CRP
Organism
Shigella flexneri
Length
210 amino acids
Function
A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity).
Mass
23.64 kDa
Sequence
MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR

Gene
crp
Protein
cAMP-activated global transcriptional regulator CRP
Organism
Pasteurella multocida (strain Pm70)
Length
209 amino acids
Function
A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity).
Mass
23.541 kDa
Sequence
MQTTPSIDPTLEWFLSHCHIHKYPSKSTLIHAGEKAETLYYLIKGSVAVLVKDEDGKEMILTYLSQGDFFGEAGLFEEGQLRSAWIKAKSPCEIAEISYKKFRQLIQVNPDILMHLSAQLARRLQNTSRQVSNLAFLDVTGRIAQTLLNLAKMPEAMTHPDGMQIKITRQEIGQMVGCSRETVGRILKMLEDQHLISAHGKTIVVYGTR

Gene
CRP
Protein
Cryparin
Organism
Cryphonectria parasitica
Length
118 amino acids
Function
Contributes to surface hydrophobicity, which is important for processes such as association of hyphae in reproductive structures, dispersal of aerial spores and adhesion of pathogens to host structures. Produced abundantly, except in the ds-RNA virus-infected strains, where the expression is much reduced.
Similarity
Belongs to the cerato-ulmin hydrophobin family.
Mass
11.387 kDa
Sequence
MQFSIIAISFLASLAMASPAKRGGGGGGSGSGSGSGSGSGSGGGSTTYTACSSTLYSEAQCCATDVLGVADLDCETVPETPTSASSFESICATSGRDAKCCTIPLLGQALLCQDPVGL