Protein
Cyclic AMP-responsive element-binding protein 3-like protein 4
Organism
Rattus norvegicus
Function
Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements. Increases the binding of CREM isoform Delta with CRE. The CREM isoform Delta-CREB3L4 heterodimer functions through CRE but not through UPRE and may recruit HIRA to CRE to regulate histone exchange (By similarity).
Similarity
Belongs to the bZIP family. ATF subfamily.
Sequence
MELGCPELLEPPEDIFSTGSFLELGFNGPPSKVPGLQKSESDDFLNLFIDPNMIRCSETSPGSDSGVSEDPGSPAPQAPSSPALYEVVYEAGALQGTQREAGPTFGLISIQIDQWSPAFMVPGACTVSDLPSEAHRHILPRVSTIAPPPPAALLSCQRLFLTDEEKHLLGQEGVTLPSHLPLTKAEERILKKIRRKIRNKQSAQDSRRRKKEYIDGLESRVAACSEQNQKLQRKVQELERQNISLVAQVHQLQKFTAQTSSRAAQTSTCVLILLFSLALIILPSFSPFQSQPEARSEGYQLHGVISRNILTHEDMTESPESPVLKANLEELPQVPATNGSTKMAHLKMRVKARPTGPIRGMVHADEM