Cpsf100

Probable cleavage and polyadenylation specificity factor subunit 2

756 amino acids

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA.

Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.

85.418 kDa

MTSIIKLHTISGAMDESPPCYILQIDDVRILLDCGWDEKFDANFIKELKRQVHTLDAVLLSHPDAYHLGALPYLVGKLGLNCPIYATIPVFKMGQMFMYDLYMSHFNMGDFDLFSLDDVDTAFEKITQLKYNQTVSLKDKGYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKKERHLSGCELDRLQRPSLLITDAYNAQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLELAHMLDQLWKNKESGLMAYSLALLNNVSYNVIEFAKSQIEWMSDKLTKAFEGARNNPFQFKHIQLCHSLADVYKLPAGPKVVLASTPDLESGFTRDLFVQWASNANNSIILTTRTSPGTLAMELVENCAPGKQIELDVRRRVDLEGAELEEYLRTQGEKLNPLIVKPDVEEESSSESEDDIEMSVITGKHDIVVRPEGRHHSGFFKSNKRHHVMFPYHEEKVKCDEYGEIINLDDYRIADATGYEFVPMEEQNKENVKKEEPGIGAEQQANGGIVDNDVQLLEKPTKLISQRKTIEVNAQVQRIDFEGRSDGESMLKILSQLRPRRVIVIHGTAEGTQVVARHCEQNVGARVFTPQKGEIIDVTSEIHIYQVRLTEGLVSQLQFQKGKDAEVAWVDGRLGMRVKAIEAPMDVTVEQDASVQEGKTLTLETLADDEIPIHNSVLINELKLSDFKQTLMRNNINSEFSGGVLWCSNGTLALRRVDAGKVAMEGCLSEEYYKIRELLYEQYAIV

CPSF100

Cleavage and polyadenylation specificity factor subunit 2

739 amino acids

CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Required for antisense-RNA-mediated gene silencing (PubMed:17008405).

Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.

82.139 kDa

MGTSVQVTPLCGVYNENPLSYLVSIDGFNFLIDCGWNDLFDTSLLEPLSRVASTIDAVLLSHPDTLHIGALPYAMKQLGLSAPVYATEPVHRLGLLTMYDQFLSRKQVSDFDLFTLDDIDSAFQNVIRLTYSQNYHLSGKGEGIVIAPHVAGHMLGGSIWRITKDGEDVIYAVDYNHRKERHLNGTVLQSFVRPAVLITDAYHALYTNQTARQQRDKEFLDTISKHLEVGGNVLLPVDTAGRVLELLLILEQHWSQRGFSFPIYFLTYVSSSTIDYVKSFLEWMSDSISKSFETSRDNAFLLRHVTLLINKTDLDNAPPGPKVVLASMASLEAGFAREIFVEWANDPRNLVLFTETGQFGTLARMLQSAPPPKFVKVTMSKRVPLAGEELIAYEEEQNRLKREEALRASLVKEEETKASHGSDDNSSEPMIIDTKTTHDVIGSHGPAYKDILIDGFVPPSSSVAPMFPYYDNTSEWDDFGEIINPDDYVIKDEDMDRGAMHNGGDVDGRLDEATASLMLDTRPSKVMSNELIVTVSCSLVKMDYEGRSDGRSIKSMIAHVSPLKLVLVHAIAEATEHLKQHCLNNICPHVYAPQIEETVDVTSDLCAYKVQLSEKLMSNVIFKKLGDSEVAWVDSEVGKTERDMRSLLPMPGAASPHKPVLVGDLKIADFKQFLSSKGVQVEFAGGGALRCGEYVTLRKVGPTGQKGGASGPQQILIEGPLCEDYYKIRDYLYSQFYLL