Protein
NADPH--cytochrome P450 reductase
Organism
Phanerochaete chrysosporium
Function
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.
Similarity
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Sequence
MAVSSSSDVIVLSVGIILAALYLFREQIFSAAKPKTVQVPSSKAAAGGNGNPRDFIAKMKEGKKRIVIFYGSQTGTAEEYAIRLAKEAKSKFGLASLVCDPEEYDFENLDQVPEDCCVFFVMATYGEGEPTDNAVQLCQNLSDESFEFSNGEHKLPGLKYVIFGLGNKTYEHYNLISRNVDRDLQKMGAIRIGERGEGDDDKSMEEDYLEWKDGMWEAFAKAMNVEEGQGGDSPDFVVTEVFDHPEEKVYLGELSARALTRTKGIHDAKNPYPAPIIAAKELFAPGSDRNCVHIELSTESSGITYQHGDHVGVWPSNADKEVDRLLYALGLHEKKDTVINIESLDPALAKVPFPVPTTYATVLRHYIDISALAGRQILGVLAKFAPNPEAEAVLKDLNSNKEHYQNIVANGCMKLGEVLQYAAGNDLHADPTASNTTAWKIPFDIIVSSIPRLQPRYYSISSSPKLYPNAIHATVVVLKYKSEKAPRVEERWIYGVGSNFLLNLKYASHHDKAATLVSDDSPSEPSIVSHYPTYSIEGPRGAYKQGDVVKVPIHVRRSTFRLPTNPKSPVIMIGPGTGVAPFRGFVQERVAMARRTIEKHGPEGLADWGPIRLYYGCRRSDQDFLYKDEWPEYAKELHGKFIMRCAFSREPPYKPDGSKIYVQDLIWEDAEQIADAILNGKGYVYICGDAKSMSKSVEETLCRILGEAKGGSAEVEGAAELKLLKERNRLLLDVWS