Protein
O-glucosyltransferase rumi homolog
Organism
Culex quinquefasciatus
Function
Protein O-glucosyltransferase. Catalyzes the reaction that attaches glucose through an O-glycosidic linkage to a conserved serine residue found in the consensus sequence C-X-S-X-[PA]-C in epidermal growth factor-like repeats. Regulates Notch signaling by glucosylating Notch in the ER, glucosylation is required for the correct folding and cleavage of Notch.
Similarity
Belongs to the glycosyltransferase 90 family.
Sequence
MQCIYFTSVLLVIFAQNGQTDDGGMCMAKETCTETQQEAPTNNLYKAADNKYITLIEEALAAYKPCESSNCSCHLDVLKTDLRPFRSGITQDLIELARSYGTKYQIIGHRMFRQRDCMFPARCSGVEHFIRPNLPKLPDMELIINCRDWPQISRHWNASREPLPVLSFSKTNDYLDIMYPTWGFWEGGPAISLYPTGLGRWDQHRVSVRKAAKVWPWEKKLQQAFFRGSRTSDERDPLVLLSRMRPELVDAQYTKNQAWRSPKDTLHAEPAQEVRLEDHCQYKYLFNFRGVAASFRFKHLFLCKSLVFHVGQEWQEFFYDSLKPWVHYVPVPVGINEWELEHLIQFFREHDQLAQEIANRGYEHIWNHLRMEDVECYWKRLLRRYGKLVKYEVKRDEELVEIF