About Products Protein Database Contact

COP6

Gene
COP6
Protein
Alpha-cuprenene synthase COP6
Organism
Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
Length
325 amino acids
Function
Alpha-cuprenene synthase; part of the gene cluster that mediates the biosynthesis of alpha-cuprenene and oxidized derivatives (PubMed:19400802). The alpha-cuprenene synthase COP6 is the only sesquiterpene synthase identified in C.cinereus that appears to be part of a biosynthetic gene cluster and is highly specific since it catalyzes the cyclization of (2E,6E)-farnesyl diphosphate into only one product, alpha-cuprenene (PubMed:19400802, PubMed:20419721). COP6 is also able to perform the cyclization of geranyl diphosphate (PubMed:20419721). The cytochrome P450 monooxygenase COX2 then oxidizes the cyclohexadiene ring of alpha-cuprenene at positions 1 and 4, yielding first alha-cuparene, followed by alpha-cuparophenol and a further yet unidentified compound resulting from one additional oxidation step (PubMed:19400802). The cytochrome P450 monooxygenase COX1 then likely catalyzes the oxidation at position 9 of the pentane ring of alpha-cuprenene to give the corresponding hydroxy or ketone derivatives (PubMed:19400802).
Similarity
Belongs to the trichodiene synthase family.
Mass
37.424 kDa
Sequence
MPAALPYNVSRDNKWDIKKIIQDFFKRCDVPYQVIPYDTELWNACLKRAKEKGYPVEPDSPMSLYRSFKVGVVITRTSYGHIQDYEILIWVATFTAFVTYADDAFQEDIQHLHSFARTFLQNEKHEHPVLEAFAQFLRESSIRFSHFVANTVVSSALRFMMSIALEFEGQNVSVSTEAREYPGYIRILSGLSDIYALFAFPMDLPRSTYIQAFPEQIDYINGTNDLLSFYKEELDCETVNFISAAATSQQVSKLEVLRNAAEKAAYSYDVVVNVLKPYPEALAAWKSFARGFCYFHTSSPRYRLGEMFHDFEHDLVCKCASCTEI