CODM

Codeine O-demethylase

360 amino acids

Non-heme dioxygenase catalyzing the conversion of codeine to morphine. Catalyzes also, with lower efficiency, the 3-O-demethylation of thebaine to oripavine and of (S)-scoulerine to 3-O-demethylscoulerine. No activity with (S)-reticuline, salutaridine, papaverine, (S)-corytuberine, oripavine, pavine or noscapine.

Belongs to the iron/ascorbate-dependent oxidoreductase family.

40.849 kDa

METPILIKLGNGLSIPSVQELAKLTLAEIPSRYTCTGESPLNNIGASVTDDETVPVIDLQNLLSPEPVVGKLELDKLHSACKEWGFFQLVNHGVDALLMDNIKSEIKGFFNLPMNEKTKYGQQDGDFEGFGQPYIESEDQRLDWTEVFSMLSLPLHLRKPHLFPELPLPFRETLESYLSKMKKLSTVVFEMLEKSLQLVEIKGMTDLFEDGLQTMRMNYYPPCPRPELVLGLTSHSDFSGLTILLQLNEVEGLQIRKEERWISIKPLPDAFIVNVGDILEIMTNGIYRSVEHRAVVNSTKERLSIATFHDSKLESEIGPISSLVTPETPALFKRGRYEDILKENLSRKLDGKSFLDYMRM