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CMLKR1

Gene
CMLKR1
Protein
Chemokine-like receptor 1
Organism
Sus scrofa
Length
363 amino acids
Function
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism (By similarity).
Similarity
Belongs to the G-protein coupled receptor 1 family.
Mass
41.384 kDa
Sequence
MDFEDYNSTYEDSYTDDFDTIVALEEFSPLEGRVVRIFLVVVYSIICFLGILGNGLVIVIATFKMKKTVNTVWFLNLAVADFLFNVFLPIHIAYAAMDYHWVFGTAMCKISNFLLIHNMYTSVFLLTVISFDRCISVLLPVWSQNHRSIRLAYMACVVIWVLAFFLSSPSLVFRDTAHLHGKISCFNNFSLSATSSSSWPTHPQMDTVGFGRQMVVTITRFLCGFLVPVLIISACYFTIVYKLRRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLYLLELHHRAMPGSVFSLGVPLATAIAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERETSML

Gene
CMLKR1
Protein
Chemokine-like receptor 1
Organism
Bos taurus
Length
362 amino acids
Function
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism (By similarity).
Similarity
Belongs to the G-protein coupled receptor 1 family.
Mass
40.711 kDa
Sequence
MEAEDYNASYEDYPDDVDPIVVLEELSPLEGRVVRILLVAVYSVICLLGILGNGLVIVMITCKMKRTVNTVWFLNLAVADFLFNVFLPVHIAYAALDYHWVFGTAMCKISNFLLIHNMFTSVFLLTVISFDRCVSVLLPVWSQNHRSVRLAYTACLVIWVLAFFLSSPSLVFRDTARLHGKISCFNNFSLSAAVSSPWPAHPQVDPVGSGRHKVVTITRFLCGFLVPGLITTACYLTIVYKLQRSRLAKTKKPFKIILTIIVTFFLCWCPYHAFYLLELRRGSVPPSVFSLGVPLATAIAIANSCMNPILYVFMGQDFKKFRVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERETGML