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CLCNKB

Gene
clcnkb
Protein
Chloride channel protein ClC-Kb
Organism
Xenopus laevis
Length
689 amino acids
Function
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, the stabilization of membrane potential, signal transduction and transepithelial transport.
Similarity
Belongs to the chloride channel (TC 2.A.49) family.
Mass
76.8 kDa
Sequence
MSRVLVIEQREGEEKTLIQKHIFRPFPNTRRVVIDHLQRLKNFLFRIGDDWYFLFALGVIMALISFTMDFTVSKMLNAHRWLQQELGGNVLLRYLSWIVYPIALVAFSTGFAQSITPHSGGSGIPELKTILSGVILEEYLTIKNFGAKVVGLTCTLSAGSTMFLGKVGPFVHLSSMIAAYLGRMRTSVAGDYENKSKEHEMLVAAAAVGVSTVFGAPISGVLFSVEVMSSHFAIRNYWRGFFAATCGAFVFRLLAVFNSEQETITAVFKTSFKISFPFDLPEMFFFAILGVVCGLIGCAYLFCQRWLLGYVRRNSLTSKLLASDKPMYSALVALLISSITFPESLGQFLASRLTMKELLTSLFDNRTWWISLSQNSSLDRSPLVDPNNLWLEWANPQFTIFGTLAFFIIMKFWMFILATTLPMPAGYFMPVFVFGAAIGRLVGETVALLYPEGIAADGIVNPIIPGGYAWQGAPAYSGAVTHSVSTALLAFEATGQIAHILPVILCVLIANAFTQKLQPSFYDGTIIVKKLPYLPRIRSRDIDSYKVNTEEFMNPDIRVLPREAGFEDVLKVITASDDSEYPVVDNTESQVLVGTVKRPQLIHFLETHESHERAGPTEKENLSEGNLGEACSIEPVTFQLSTWTSLHQAHHLFELLHLQKAFVTKYGRIVGQVTRKEMKKAIEDLANPK

Gene
CLCNKB
Protein
Chloride channel protein ClC-Kb
Organism
Homo sapiens
Length
687 amino acids
Function
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.
Similarity
Belongs to the chloride channel (TC 2.A.49) family. CLCNKB subfamily.
Mass
75.446 kDa
Sequence
MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLMALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGLCGILGSAYLFCQRIFFGFIRNNRFSSKLLATSKPVYSALATLVLASITYPPSAGRFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTHTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVRVEHFMNHSITTLAKDMPLEEVVKVVTSTDVAKYPLVESTESQILVGIVRRAQLVQALKAEPPSWAPGHQQCLQDILAAGCPTEPVTLKLSPETSLHEAHNLFELLNLHSLFVTSRGRAVGCVSWVEMKKAISNLTNPPAPK

Gene
Clcnkb
Protein
Chloride channel protein ClC-Kb
Organism
Mus musculus
Length
687 amino acids
Function
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. May be the basolateral chloride channel mediating net chloride absorption in CTAL cells.
Similarity
Belongs to the chloride channel (TC 2.A.49) family. CLCNKB subfamily.
Mass
75.009 kDa
Sequence
MEELVGLREGASKKPVPLQELWGPCPRIRRNIQGGLEWLKERLFRVGEDWYFLVALGVLMALISYAMNFTIGRVVRAHKWLYREIGDGHLLRYLSWTVYPVALLSFSSGFSQSITPSSGGSGIPEVKTILTGVVLEDYLDIKNFGAKVVGLSCTLATGSTIFLGKLGPFVHLSVMIAAYLGRVRTKTVGEPESKTKEMELLAAGAAVGVATVFAAPISGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFHLLAVFNNEQETITSIYKTSFPVDIPFDLPEIFFFVALGAICGILSCGYNYSQRTFLFFLKANGFTSKLLATSKPLYSALAAVVLASITYPPGVGHFMASRLSMSEHLETLFDNNSWALMTKNSSPPWAAEPDPQKLWLEWCHPQLTVFGTLVFFLVMKFWMLILATTIPIPAGYFLPIFIYGAVIGRLFGEVLSVAFPEGIVAGGRVNPIMPGAYALAGAAAFSGAVTHTLSTALLAFEVTGQLVHALPVLMAVLAANAISQSFQPSFYDGTIIVKKLPYLPWIRGRQIGSHSVTVGHFMNCALTTLAKDMPLEQVIQVVISTDVTQYPLVETTESQTLVGVVKRTHLVQALQTEPASWAPGQQPCLQDILANGCPTQPVTLQLSLETSLHETHNLFELLNLQTLFVTSRGRAVGSVSWVELKKAISTLTNPPAPK

Gene
Clcnkb
Protein
Chloride channel protein ClC-Kb
Organism
Rattus norvegicus
Length
687 amino acids
Function
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.
Similarity
Belongs to the chloride channel (TC 2.A.49) family. CLCNKB subfamily.
Mass
75.218 kDa
Sequence
MEEIVGLREGSPRKPVPLQELWRPCPRIRRNIQGSLEWLKERLFRVGEDWYFLVALGVLMALISYAMNFAIGRVVRAHKWLYREIGDGHLLRYLSWTVYPVALLSFSSGFSQSITPSSGGSGIPEVKTILTGVILEDYLDIKNFGAKVVGLSCTLATGSTIFLGKLGPFVHLSVMIAAYLGRVRTKTVGEPENKTKEMELLAAGAAVGVATVFAAPISGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFHLLAVFNSEQETITSIYKTSFPVDIPFDLPEIFFFVALGAICGILSCGYNYCQRTSLFFLKSNGFTSKLLATSKPLYSALAAVVLASITYPPGVGRFMASRLSMSEYLETLFDNNSWALMTKNSSPPWSAEPDPQNLWLEWCHPQMTVFGTLVFFLVMKFWMLILATTIPIPAGYFLPIFVYGAAIGRLFGEVLSLAFPEGIVAGGKVSPIMPGAYALAGAAAFSGAVTHTLSTALLAFEVSGQIVHALPVLMAVLAANAICQSYQPSFYDGTIIVKKLPYLPWIRGRKIGSHLVTVGHFMNCTLTTLAKDMPLEEVIKVVISTDVTQYPLVETTESQVLVGIVKRTHLVQSLHTDSASWAPGQQPCLQDILANGCPTQPVTLQLSTETSLHETHNLFELLNLQLLFVTSRGRAVGSVSWVELKKAISTLTNPPAPK

Gene
CLCNKB
Protein
Chloride channel protein ClC-Kb
Organism
Oryctolagus cuniculus
Length
678 amino acids
Function
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.
Similarity
Belongs to the chloride channel (TC 2.A.49) family. CLCNKB subfamily.
Mass
74.469 kDa
Sequence
MEELVGLREGSSGNPVALRELWSPCPRLRRGIRGGLEWLKQKLFRVGEDWYFLMTLGVLMALISYAMNFALGRVVRAHKWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPFSGGSGIPELKTILSGVVLENYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTKTIGEAENKSKQNEMLVAGAAVGVATVFAAPFSGVLFCIEVMSSHFSVWDYWRGFFAATCGAFMFRLLAVFNSEQETITSLYKTSFPVDVPFDLPEIFFFVLLGAICGVASCAYLYCQRTFLAFTKTNKLISKLMATSKPLYAALAATVLASITYPPGVGRFMASRLSMREHLDTLFDNHSWALLTRNSSPPWPAEPDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFLPIFIIGAAIGRLLGEALSVAFPEGIVAGGVINPIMPGGYALAGAAAFSGAVTHSISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIMVKKLPYLPWIRGRPINSHRVIVEHFMRRAISTLARDAALEQVVKVLTSTDEAEYPLVESTESQLLVGIVQRAQLVQALQAEAPARASGQQRCLQDILAGGCPTEPVTLTLSPETSLHQAHNLFELLNLRSLYVTSKGRAVVYVSWVERQHTGF