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CHRDL1

Gene
CHRDL1
Protein
Chordin-like protein 1
Organism
Gallus gallus
Length
456 amino acids
Function
Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors.
Mass
52.399 kDa
Sequence
MRRKWRSEDFHFVFFGVLCLLLIDRGKLEQVKHSDTYCVFQDKKYRVGERWHPYLEPYGLVYCVNCLCSENGNVLCSRIRCPSLHCPSPVHVPQLCCPRCPEDSLFSVSSKITGKSCEYNGTTYHHGEMFVAEGLFQNRQANQCAQCSCSEGNVYCGLKTCPKLTCSFPVSVPESCCPVCRGDGELSWEQADGDIFRQPANREARHSYHRPHYELSPSSTRQVVNVPRFPSARSNRGVLPDPQQASGTIVQIVINNKHKHGRVCVSNGKTYSHGESWHPNLRAFGIVECVLCTCNITKQECKKIHCPEQYPCKYPQKVEGKCCKVCPEEVPSQSFDNKDYFCGKETFPVYESIFTEEGETIRKIAVETEKPPQIEIHVWTIRKGILRHFYIEKMSKREFEELPYFKQITRTTSSQWKIFSEGEAQISQMCESRVCRTELEDLVKVLYLEKSEKGHC

Gene
CHRDL1
Protein
Chordin-like protein 1
Organism
Homo sapiens
Length
456 amino acids
Function
Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development.
Mass
52.026 kDa
Sequence
MRKKWKMGGMKYIFSLLFFLLLEGGKTEQVKHSETYCMFQDKKYRVGERWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPDSLPPVNNKVTSKSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVCRGDGELSWEHSDGDIFRQPANREARHSYHRSHYDPPPSRQAGGLSRFPGARSHRGALMDSQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQECKKIHCPNRYPCKYPQKIDGKCCKVCPGKKAKELPGQSFDNKGYFCGEETMPVYESVFMEDGETTRKIALETERPPQVEVHVWTIRKGILQHFHIEKISKRMFEELPHFKLVTRTTLSQWKIFTEGEAQISQMCSSRVCRTELEDLVKVLYLERSEKGHC

Gene
Chrdl1
Protein
Chordin-like protein 1
Organism
Mus musculus
Length
447 amino acids
Function
Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation (By similarity). Antagonizes the function of BMP7 and may thus play an important role in the embryonic bone formation. Shows no inhibitory effect on the inducing activity of BMP2. Plays a role during anterior segment eye development (By similarity).
Mass
50.732 kDa
Sequence
MDGMKYIISLFFIFVFLEGSKTEQVKHSDTYCVFQDKKYRVGEKWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPSLHCLSPVHIPHLCCPRCPDSLPPVNNKVTSKSCEYNGTTYQHGELFIAEGLFQNRQPNQCSQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVCRGDAELSWEHADGDIFRQPANREARHSYLRSPYDPPPNRQAGGLPRFPGSRSHRGAVIDSQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQECKKIHCPNRYPCKYPQKIDGKCCKVCPEEPPSQNFDSKGSFCGEETMPVYESVFMEDGETTRKVALETERPPQVEVHVWTIQKGILQHFHIEKISKRMFGELHHFKLVTRTTLNQWKLFTEGEAQLSQMCSSQVCRTELEDLVQVLYLGRPEKDHC

Gene
Chrdl1
Protein
Chordin-like protein 1
Organism
Rattus norvegicus
Length
447 amino acids
Function
Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. Plays a role during anterior segment eye development (By similarity).
Mass
50.56 kDa
Sequence
MEGIKYIASLVFFFVFLEASKTEPVKHSETYCMFQDKKYRVGEKWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPTLHCLSPVHIPHLCCPRCPDSLPPMNSKVTSKSCEYNGTTYQHGELFIAEGLFQNRQPNQCSQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVCRGDGELSWEHSDADIFRQPANREARHSYLRSPYDPPPSRQAGGLPRFAGSRSHRGAVIDSQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQECKKIHCPNRYPCKYPQKLDGKCCKVCPEEPPSQNFDSKGSFCGEETMPVYEAVLVEDGETARKVALETEKPPQVEVHVWTIRKGILQHFHIEKISKEMFGGLHHFKLVTRTTMNQWKIFAEGEAQLSQMCSSRVCRTELEDLVQVLYLERPEKDHC