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CHGA

Gene
Chga
Protein
Chromogranin-A
Organism
Rattus norvegicus
Length
466 amino acids
Function
Serpinin regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (By similarity). Serpinin and pGlu-serpinin can enhance both myocardial contractility (inotropy) and relaxation (lusitropy) and this cardio-stimulation requires a beta 1-adrenergic receptor/adenylate cyclase/cAMP/PKA pathway (PubMed:22459152).
Similarity
Belongs to the chromogranin/secretogranin protein family.
Mass
52.024 kDa
Sequence
MRSSAALALLLCAGQVFALPVNSPMTKGDTKVMKCVLEVISDSLSKPSPMPVSPECLETLQGDERVLSILRHQNLLKELQDLALQGAKERAQQQQQQQQQQQQQQQQQQQQHSSFEDELSEVFENQSPAAKHGDAASEAPSKDTVEKREDSDKGQQDAFEGTTEGPRPQAFPEPKQESSMMGNSQSPGEDTANNTQSPTSLPSQEHGIPQTTEGSERGPSAQQQARKAKQEEKEEEEEEKEEEEEEKEEKAIAREKAGPKEVPTAASSSHFYSGYKKIQKDDDGQSESQAVNGKTGASEAVPSEGKGELEHSQQEEDGEEAMAGPPQGLFPGGKGQELERKQQEEEEEEERLSREWEDKRWSRMDQLAKELTAEKRLEGEDDPDRSMKLSFRARAYGFRDPGPQLRRGWRPSSREDSVEARGDFEEKKEEEGSANRRAEDQELESLSAIEAELEKVAHQLQALRRG

Gene
Chga
Protein
Chromogranin-A
Organism
Rattus norvegicus
Length
466 amino acids
Function
Serpinin regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (By similarity). Serpinin and pGlu-serpinin can enhance both myocardial contractility (inotropy) and relaxation (lusitropy) and this cardio-stimulation requires a beta 1-adrenergic receptor/adenylate cyclase/cAMP/PKA pathway (PubMed:22459152).
Similarity
Belongs to the chromogranin/secretogranin protein family.
Mass
52.024 kDa
Sequence
MRSSAALALLLCAGQVFALPVNSPMTKGDTKVMKCVLEVISDSLSKPSPMPVSPECLETLQGDERVLSILRHQNLLKELQDLALQGAKERAQQQQQQQQQQQQQQQQQQQQHSSFEDELSEVFENQSPAAKHGDAASEAPSKDTVEKREDSDKGQQDAFEGTTEGPRPQAFPEPKQESSMMGNSQSPGEDTANNTQSPTSLPSQEHGIPQTTEGSERGPSAQQQARKAKQEEKEEEEEEKEEEEEEKEEKAIAREKAGPKEVPTAASSSHFYSGYKKIQKDDDGQSESQAVNGKTGASEAVPSEGKGELEHSQQEEDGEEAMAGPPQGLFPGGKGQELERKQQEEEEEEERLSREWEDKRWSRMDQLAKELTAEKRLEGEDDPDRSMKLSFRARAYGFRDPGPQLRRGWRPSSREDSVEARGDFEEKKEEEGSANRRAEDQELESLSAIEAELEKVAHQLQALRRG

Gene
Chga
Protein
Chromogranin-A
Organism
Mus musculus
Length
463 amino acids
Function
Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (PubMed:21436258). Pyroglutaminated (pGlu)-serpinin exerts an antiapoptotic effect on cells exposed to oxidative stress (PubMed:21537909).
Similarity
Belongs to the chromogranin/secretogranin protein family.
Mass
51.789 kDa
Sequence
MRSTAVLALLLCAGQVFALPVNSPMTKGDTKVMKCVLEVISDSLSKPSPMPVSPECLETLQGDERILSILRHQNLLKELQDLALQGAKERAQQPLKQQQPPKQQQQQQQQQQQEQQHSSFEDELSEVFENQSPDAKHRDAAAEVPSRDTMEKRKDSDKGQQDGFEATTEGPRPQAFPEPNQESPMMGDSESPGEDTATNTQSPTSLPSQEHVDPQATGDSERGLSAQQQARKAKQEEKEEEEEEEAVAREKAGPEEVPTAASSSHFHAGYKAIQKDDGQSDSQAVDGDGKTEASEALPSEGKGELEHSQQEEDGEEAMVGTPQGLFPQGGKGRELEHKQEEEEEEEERLSREWEDKRWSRMDQLAKELTAEKRLEGEDDPDRSMKLSFRTRAYGFRDPGPQLRRGWRPSSREDSVEARSDFEEKKEEEGSANRRAEDQELESLSAIEAELEKVAHQLQALRRG

Gene
Chga
Protein
Chromogranin-A
Organism
Mus musculus
Length
463 amino acids
Function
Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (PubMed:21436258). Pyroglutaminated (pGlu)-serpinin exerts an antiapoptotic effect on cells exposed to oxidative stress (PubMed:21537909).
Similarity
Belongs to the chromogranin/secretogranin protein family.
Mass
51.789 kDa
Sequence
MRSTAVLALLLCAGQVFALPVNSPMTKGDTKVMKCVLEVISDSLSKPSPMPVSPECLETLQGDERILSILRHQNLLKELQDLALQGAKERAQQPLKQQQPPKQQQQQQQQQQQEQQHSSFEDELSEVFENQSPDAKHRDAAAEVPSRDTMEKRKDSDKGQQDGFEATTEGPRPQAFPEPNQESPMMGDSESPGEDTATNTQSPTSLPSQEHVDPQATGDSERGLSAQQQARKAKQEEKEEEEEEEAVAREKAGPEEVPTAASSSHFHAGYKAIQKDDGQSDSQAVDGDGKTEASEALPSEGKGELEHSQQEEDGEEAMVGTPQGLFPQGGKGRELEHKQEEEEEEEERLSREWEDKRWSRMDQLAKELTAEKRLEGEDDPDRSMKLSFRTRAYGFRDPGPQLRRGWRPSSREDSVEARSDFEEKKEEEGSANRRAEDQELESLSAIEAELEKVAHQLQALRRG

Gene
CHGA
Protein
Chromogranin-A
Organism
Homo sapiens
Length
457 amino acids
Function
Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
Similarity
Belongs to the chromogranin/secretogranin protein family.
Mass
50.688 kDa
Sequence
MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG

Gene
CHGA
Protein
Chromogranin-A
Organism
Homo sapiens
Length
457 amino acids
Function
Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
Similarity
Belongs to the chromogranin/secretogranin protein family.
Mass
50.688 kDa
Sequence
MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG

Gene
CHGA
Protein
Chromogranin-A
Organism
Bos taurus
Length
449 amino acids
Function
Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (PubMed:21436258).
Similarity
Belongs to the chromogranin/secretogranin protein family.
Mass
50.015 kDa
Sequence
MRSAAVLALLLCAGQVIALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSKECFETLRGDERILSILRHQNLLKELQDLALQGAKERTHQQKKHSSYEDELSEVLEKPNDQAEPKEVTEEVSSKDAAEKRDDFKEVEKSDEDSDGDRPQASPGLGPGPKVEEDNQAPGEEEEAPSNAHPLASLPSPKYPGPQAKEDSEGPSQGPASREKGLSAEQGRQTEREEEEEKWEEAEAREKAVPEEESPPTAAFKPPPSLGNKETQRAAPGWPEDGAGKMGAEEAKPPEGKGEWAHSRQEEEEMARAPQVLFRGGKSGEPEQEEQLSKEWEDAKRWSKMDQLAKELTAEKRLEGEEEEEEDPDRSMRLSFRARGYGFRGPGLQLRRGWRPNSREDSVEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLEELRRG

Gene
CHGA
Protein
Chromogranin-A
Organism
Bos taurus
Length
449 amino acids
Function
Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation (PubMed:21436258).
Similarity
Belongs to the chromogranin/secretogranin protein family.
Mass
50.015 kDa
Sequence
MRSAAVLALLLCAGQVIALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSKECFETLRGDERILSILRHQNLLKELQDLALQGAKERTHQQKKHSSYEDELSEVLEKPNDQAEPKEVTEEVSSKDAAEKRDDFKEVEKSDEDSDGDRPQASPGLGPGPKVEEDNQAPGEEEEAPSNAHPLASLPSPKYPGPQAKEDSEGPSQGPASREKGLSAEQGRQTEREEEEEKWEEAEAREKAVPEEESPPTAAFKPPPSLGNKETQRAAPGWPEDGAGKMGAEEAKPPEGKGEWAHSRQEEEEMARAPQVLFRGGKSGEPEQEEQLSKEWEDAKRWSKMDQLAKELTAEKRLEGEEEEEEDPDRSMRLSFRARGYGFRGPGLQLRRGWRPNSREDSVEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLEELRRG

Gene
CHGA
Protein
Chromogranin-A
Organism
Equus caballus
Length
448 amino acids
Function
Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
Similarity
Belongs to the chromogranin/secretogranin protein family.
Mass
49.861 kDa
Sequence
MRSAVVLALLLCAGQVIALPVNSPMDTGDTEVMKCIVEVISDTLSKPSPVPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAPQQKHSRLEDELAEVLEKQNHQAELKEVTEEALSEDAAEARGDSKEVEENGEDADGARPQAALEPEQESRVEDAQAPGEEKEAINTHSPTRLPSQKHPDPQAEGDSDSPSQGLVDREKGLGAERGQQAKREEEEDEAGEKADAEEEGPTAAFNPHPSLSYKIRKGESWSEALVVDGARKTGAEEAQPPEGQGEREHSRQEEEEEEETAGASRGLFRGGKSRELEQEKEQERLSKEWEDAKRWSKMDQLAKELTAEKRLEGEDEEEDDPDRSMKLSFRARAYGFRGPGLQLRRGWRPSSREDSIEAGLPPPVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG

Gene
CHGA
Protein
Chromogranin-A
Organism
Equus caballus
Length
448 amino acids
Function
Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
Similarity
Belongs to the chromogranin/secretogranin protein family.
Mass
49.861 kDa
Sequence
MRSAVVLALLLCAGQVIALPVNSPMDTGDTEVMKCIVEVISDTLSKPSPVPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAPQQKHSRLEDELAEVLEKQNHQAELKEVTEEALSEDAAEARGDSKEVEENGEDADGARPQAALEPEQESRVEDAQAPGEEKEAINTHSPTRLPSQKHPDPQAEGDSDSPSQGLVDREKGLGAERGQQAKREEEEDEAGEKADAEEEGPTAAFNPHPSLSYKIRKGESWSEALVVDGARKTGAEEAQPPEGQGEREHSRQEEEEEEETAGASRGLFRGGKSRELEQEKEQERLSKEWEDAKRWSKMDQLAKELTAEKRLEGEDEEEDDPDRSMKLSFRARAYGFRGPGLQLRRGWRPSSREDSIEAGLPPPVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG

Gene
CHGA
Protein
Chromogranin-A
Organism
Sus scrofa
Length
446 amino acids
Function
Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
Similarity
Belongs to the chromogranin/secretogranin protein family.
Mass
49.328 kDa
Fragment
single
Sequence
SAAALALLLCAGQVIALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERSHQQKKQSSYEDELSEVLEKQNDQAELKEGTEEASSKEAAEKRGDSKEVEKNDEDADGAKPQASLEPPXXXEAEDQTPGEEEAASTHPLASLPSKKRPGAQAEEDHEGPSQGPVDREKGPSAEQGPQAEREEEEEAEAGEKAVPEEEGPRSEAFDSHPSLGYKEMQRGWPQAPAMDGAGKTGAEEAQPPEGKGAREHSRQEEEEETAGAPQGLFRGGKRGEPAQEEEERLSEEWENAKRWSKMDRLAKELTAEKRLQGEEEEEEEEEDPDRSMKLSFRAPAYGFRGPGLQLRRGWRPSSREDSVEAGLPLQVRXYLEEKKEEEGSANRRPEDQELESLSAIEAELEKVAPQLQSLRRG

Gene
CHGA
Protein
Chromogranin-A
Organism
Sus scrofa
Length
446 amino acids
Function
Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
Similarity
Belongs to the chromogranin/secretogranin protein family.
Mass
49.328 kDa
Fragment
single
Sequence
SAAALALLLCAGQVIALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERSHQQKKQSSYEDELSEVLEKQNDQAELKEGTEEASSKEAAEKRGDSKEVEKNDEDADGAKPQASLEPPXXXEAEDQTPGEEEAASTHPLASLPSKKRPGAQAEEDHEGPSQGPVDREKGPSAEQGPQAEREEEEEAEAGEKAVPEEEGPRSEAFDSHPSLGYKEMQRGWPQAPAMDGAGKTGAEEAQPPEGKGAREHSRQEEEEETAGAPQGLFRGGKRGEPAQEEEERLSEEWENAKRWSKMDRLAKELTAEKRLQGEEEEEEEEEDPDRSMKLSFRAPAYGFRGPGLQLRRGWRPSSREDSVEAGLPLQVRXYLEEKKEEEGSANRRPEDQELESLSAIEAELEKVAPQLQSLRRG

Gene
CHGA
Protein
Chromogranin-A
Organism
Struthio camelus
Length
104 amino acids
Function
Chromogranin A probably has a paracrine role in the regulation of secretion or maturation.
Similarity
Belongs to the chromogranin/secretogranin protein family.
Mass
11.674 kDa
Fragment
multiple
Sequence
LPVTNNMNKGDTKVMKCIVEVISDTLSKPNPLPISEECLETLRGDERIISILRHQNLLKELQEIAVQGANERTQQQRRTEDQELESLAAIEAELESVAHSLQAL

Gene
CHGA
Protein
Chromogranin-A
Organism
Struthio camelus
Length
104 amino acids
Function
Chromogranin A probably has a paracrine role in the regulation of secretion or maturation.
Similarity
Belongs to the chromogranin/secretogranin protein family.
Mass
11.674 kDa
Fragment
multiple
Sequence
LPVTNNMNKGDTKVMKCIVEVISDTLSKPNPLPISEECLETLRGDERIISILRHQNLLKELQEIAVQGANERTQQQRRTEDQELESLAAIEAELESVAHSLQAL