Protein
Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial
Organism
Drosophila melanogaster
Function
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.
Similarity
Belongs to the KAE1 / TsaD family.
Sequence
MHALRNFAGNGIANVFGCGIRRRLSYVLGIETSCDDTGIAIVDTTGRVIANVLESQQEFHTRYGGIIPPRAQDLHRARIESAYQRCMEAAQLKPDQLTAIAVTTRPGLPLSLLVGVRFARHLARRLQKPLLPVHHMEAHALQARMEHPEQIGYPFLCLLASGGHCQLVVANGPGRLTLLGQTLDDAPGEAFDKIGRRLRLHILPEYRLWNGGRAIEHAAQLASDPLAYEFPLPLAQQRNCNFSFAGIKNNSFRAIRARERAERTPPDGVISNYGDFCAGLLRSVSRHLMHRTQRAIEYCLLPHRQLFGDTPPTLVMSGGVANNDAIYANIEHLAAQYGCRSFRPSKRYCSDNGVMIAWHGVEQLLQDKEASTRYDYDSIDIQGSAGFAESHEEAVAAAAIKCKWIQPLV