CENPU

Centromere protein U

418 amino acids

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.

Belongs to the CENP-U/AME1 family.

47.522 kDa

MAPRGRRRPRPHRSEGARRSKNTLERTHSMKDKAGQKCKPIDVFDFPDNSDVSSIGRLGENEKDEETYETFDPPLHSTAIYADEEEFSKHCGLSLSSTPPGKEAKRSSDTSGNEASEIESVKISAKKPGRKLRPISDDSESIEESDTRRKVKSAEKISTQRHEVIRTTASSELSEKPAESVTSKKTGPLSAQPSVEKENLAIESQSKTQKKGKISHDKRKKSRSKAIGSDTSDIVHIWCPEGMKTSDIKELNIVLPEFEKTHLEHQQRIESKVCKAAIATFYVNVKEQFIKMLKESQMLTNLKRKNAKMISDIEKKRQRMIEVQDELLRLEPQLKQLQTKYDELKERKSSLRNAAYFLSNLKQLYQDYSDVQAQEPNVKETYDSSSLPALLFKARTLLGAESHLRNINHQLEKLLDQG

CENPU

Centromere protein U

418 amino acids

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.

Belongs to the CENP-U/AME1 family.

47.522 kDa

MAPRGRRRPRPHRSEGARRSKNTLERTHSMKDKAGQKCKPIDVFDFPDNSDVSSIGRLGENEKDEETYETFDPPLHSTAIYADEEEFSKHCGLSLSSTPPGKEAKRSSDTSGNEASEIESVKISAKKPGRKLRPISDDSESIEESDTRRKVKSAEKISTQRHEVIRTTASSELSEKPAESVTSKKTGPLSAQPSVEKENLAIESQSKTQKKGKISHDKRKKSRSKAIGSDTSDIVHIWCPEGMKTSDIKELNIVLPEFEKTHLEHQQRIESKVCKAAIATFYVNVKEQFIKMLKESQMLTNLKRKNAKMISDIEKKRQRMIEVQDELLRLEPQLKQLQTKYDELKERKSSLRNAAYFLSNLKQLYQDYSDVQAQEPNVKETYDSSSLPALLFKARTLLGAESHLRNINHQLEKLLDQG

Cenpu

Centromere protein U

410 amino acids

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression (By similarity).

Belongs to the CENP-U/AME1 family.

46.37 kDa

MAARRSLRYSGNPGAKHSKNTLRSTYSRKQKAGPKPRPKDVFDFSNNSDASSIPGALEEEEETYETFDPPLHSTAIYAEDELSKHCVSSSSLATHRGKASRNLDPSEDEASGNESIKVSTKKPRRKLEPISGESDSSADDVRRRVASAEGPRSQQRQAAPAAPSPPERPAEPVTPRRTRLHSAQLSPVDETPATQSQLKTQKKVRPSPGRRKRPRRGHTDTDGSESMHIWCLEGKRQSDITELDVILSVFEKTFLEYKQRVESESCNQAINKFYFKMKGELIRMLKEAQMLKALKMKNTKIIANMEKKRQRLIEVQDELIRLEPQLKQLQTKYDDLKERKSSLKKSKHFLSNLKQLCQDYSNVQEKGPKGTGKYDSSSLPALLFKARSILGAENHLRTINYQLGKLLELD

Cenpu

Centromere protein U

410 amino acids

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression (By similarity).

Belongs to the CENP-U/AME1 family.

46.801 kDa

MAARRSLRYSGDPGAKRSRNTLGSTNSRKQKAGQKPKRKDVFDFPNTSDVSSMLRELEEEEPYETFDPPLHSTAIYTDDELYKHCVSSTSPATHRGKESRNLNPSENEASGNDSIKLSAKKPRRKLEPISDESDSSEDNVRRSVSIERPRARKPPAAPAAASSSSSPSERPAEQVTPRKTSFPQPSAVEETPAAQSQLKTQKKVRPSPGRRKRPRRGSTHSDASESMHILCLEGKRQSDVMELDVVLSAFERTFLDYKQRVESESCNQAISKFYFKIKGELIRMLKEVQMLKALKRKNTKIISNMEKKRQRLIDVQDELIRLEPQLKQLQTKYDDLKKRKSALKNSKHFLSNLKQLYQDYSNVREEEPKEKEKYDSSSLPALLFKARSILGAEKHLKTINYHLGKLLKQD

Cenpu

Centromere protein U

410 amino acids

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression (By similarity).

Belongs to the CENP-U/AME1 family.

46.37 kDa

MAARRSLRYSGNPGAKHSKNTLRSTYSRKQKAGPKPRPKDVFDFSNNSDASSIPGALEEEEETYETFDPPLHSTAIYAEDELSKHCVSSSSLATHRGKASRNLDPSEDEASGNESIKVSTKKPRRKLEPISGESDSSADDVRRRVASAEGPRSQQRQAAPAAPSPPERPAEPVTPRRTRLHSAQLSPVDETPATQSQLKTQKKVRPSPGRRKRPRRGHTDTDGSESMHIWCLEGKRQSDITELDVILSVFEKTFLEYKQRVESESCNQAINKFYFKMKGELIRMLKEAQMLKALKMKNTKIIANMEKKRQRLIEVQDELIRLEPQLKQLQTKYDDLKERKSSLKKSKHFLSNLKQLCQDYSNVQEKGPKGTGKYDSSSLPALLFKARSILGAENHLRTINYQLGKLLELD

Cenpu

Centromere protein U

410 amino acids

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression (By similarity).

Belongs to the CENP-U/AME1 family.

46.801 kDa

MAARRSLRYSGDPGAKRSRNTLGSTNSRKQKAGQKPKRKDVFDFPNTSDVSSMLRELEEEEPYETFDPPLHSTAIYTDDELYKHCVSSTSPATHRGKESRNLNPSENEASGNDSIKLSAKKPRRKLEPISDESDSSEDNVRRSVSIERPRARKPPAAPAAASSSSSPSERPAEQVTPRKTSFPQPSAVEETPAAQSQLKTQKKVRPSPGRRKRPRRGSTHSDASESMHILCLEGKRQSDVMELDVVLSAFERTFLDYKQRVESESCNQAISKFYFKIKGELIRMLKEVQMLKALKRKNTKIISNMEKKRQRLIDVQDELIRLEPQLKQLQTKYDDLKKRKSALKNSKHFLSNLKQLYQDYSNVREEEPKEKEKYDSSSLPALLFKARSILGAEKHLKTINYHLGKLLKQD

CENPU

Centromere protein U

408 amino acids

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression (By similarity).

Belongs to the CENP-U/AME1 family.

46.674 kDa

single

DRPRPARLSHARFSKNHSGRTHSMKDKAGRKHRPLDVFDFPDHSQLSSFSRLGENEKDEESYETFDPPLHSTAIYADEEEFSKQCGSHLPSTPQEKEAKRSSDTSEIEASENESVKISAKKPRRKLKPISDESESPEESDVRRKVKPTENISTQHEAVSATALPGLSEKPAEAVTPQKTGPQSAESSAEKATLATEHQLETQKNKMLPGKRKKPRSYTTDTSDCAPVWCLKEKKASEIMELDVFLSAFENILLEYEQKIDSRVCKAAINKFHSNLKEELIKMVQEIQMLKTLKRKNAKIISNIEKKRQRLIEVQDELLQVEPELKQLQIKYEELQERKASLRKAAYFLSNLKQLHQDYSDVQEEEPSVKETYDSSSLPALLFKARPLLGAEHHLQNINYQLENLLDQK

CENPU

Centromere protein U

408 amino acids

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression (By similarity).

Belongs to the CENP-U/AME1 family.

46.674 kDa

single

DRPRPARLSHARFSKNHSGRTHSMKDKAGRKHRPLDVFDFPDHSQLSSFSRLGENEKDEESYETFDPPLHSTAIYADEEEFSKQCGSHLPSTPQEKEAKRSSDTSEIEASENESVKISAKKPRRKLKPISDESESPEESDVRRKVKPTENISTQHEAVSATALPGLSEKPAEAVTPQKTGPQSAESSAEKATLATEHQLETQKNKMLPGKRKKPRSYTTDTSDCAPVWCLKEKKASEIMELDVFLSAFENILLEYEQKIDSRVCKAAINKFHSNLKEELIKMVQEIQMLKTLKRKNAKIISNIEKKRQRLIEVQDELLQVEPELKQLQIKYEELQERKASLRKAAYFLSNLKQLHQDYSDVQEEEPSVKETYDSSSLPALLFKARPLLGAEHHLQNINYQLENLLDQK

CENPU

Centromere protein U

345 amino acids

Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Required for maintenance of sister chromatid adhesion during mitotic checkpoint activation.

Belongs to the CENP-U/AME1 family.

39.638 kDa

MSSKKRTKRNRAGDEYKEHKGRSHPRRKFLPPEEPDVSRISKVAGVNQLEELCDSFDQPLHSTAVDACGEEHSENESSGYVPAPQRTNAERSEKMLLETPEGDVHEFSQSGSVREPLMENLNAPNTTRSEVKKKRPSKKSSSDSSVNSPSSVQLWCPNKLKRSSRDITELDVVLAEFEKIAANYRQSIESKACRKAVSAFCSAFEDQVTDLITEVQELKNTKKKNAKVVADIKKKRQRLMQVREKLSRTEPQLIKLQKEYAEVEERRSSLRQVVQFLTDLKELQQDYLDYREENPRKKVVYGASSLPALLVESRRILQAERHFQNINRKLEYALEVQRGKLAKEH

CENPU

Centromere protein U

345 amino acids

Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Required for maintenance of sister chromatid adhesion during mitotic checkpoint activation.

Belongs to the CENP-U/AME1 family.

39.638 kDa

MSSKKRTKRNRAGDEYKEHKGRSHPRRKFLPPEEPDVSRISKVAGVNQLEELCDSFDQPLHSTAVDACGEEHSENESSGYVPAPQRTNAERSEKMLLETPEGDVHEFSQSGSVREPLMENLNAPNTTRSEVKKKRPSKKSSSDSSVNSPSSVQLWCPNKLKRSSRDITELDVVLAEFEKIAANYRQSIESKACRKAVSAFCSAFEDQVTDLITEVQELKNTKKKNAKVVADIKKKRQRLMQVREKLSRTEPQLIKLQKEYAEVEERRSSLRQVVQFLTDLKELQQDYLDYREENPRKKVVYGASSLPALLVESRRILQAERHFQNINRKLEYALEVQRGKLAKEH