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CENPH

Gene
CENPH
Protein
Centromere protein H
Organism
Homo sapiens
Length
247 amino acids
Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.
Similarity
Belongs to the CENP-H/MCM16 family.
Mass
28.481 kDa
Sequence
MEEQPQMQDADEPADSGGEGRAGGPPQVAGAQAACSEDRMTLLLRLRAQTKQQLLEYKSMVDASEEKTPEQIMQEKQIEAKIEDLENEIEEVKVAFEIKKLALDRMRLSTALKKNLEKISRQSSVLMDNMKHLLELNKLIMKSQQESWDLEEKLLDIRKKRLQLKQASESKLLEIQTEKNKQKIDLDSMENSERIKIIRQNLQMEIKITTVIQHVFQNLILGSKVNWAEDPALKEIVLQLEKNVDMM

Gene
CENPH
Protein
Centromere protein H
Organism
Bos taurus
Length
244 amino acids
Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity).
Similarity
Belongs to the CENP-H/MCM16 family.
Mass
28.064 kDa
Sequence
METQSEEQAVTKPADSGGEGGPPQVAGAQAARPEDRMTLLLRLRAQTKQQLLEYKSMVDANEEKTPEQIMQEKQIEAKIEELENEVEEAKTAFEMKKLALDRMQLSTALKKHLEKVDIKTSVLMDNMKQILNLNKLIMKSQQETWDLEEKLLDVRKKRLQLKQASERKLLEIQTEKNKQKDDLDSMENSDKIKAIQQNLETEIQITTVIQHVFQNLILGSKVNWAEDPALKETVLQLEKNLTMI

Gene
Cenph
Protein
Centromere protein H
Organism
Mus musculus
Length
241 amino acids
Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate (By similarity).
Similarity
Belongs to the CENP-H/MCM16 family.
Mass
28.135 kDa
Sequence
MEEQPRERSEAGAEACEEKRGLSQAAEERIEDRISLLLRLRAQTKQQLLEYKSMIDTNEEKTPEQIMQEKQIEVKIEELENEIEDVKSNIEMKSLALSRMKLSVALRDNMENMGPENCVLTDDMKHILKLQKLIMKSQEESSELEKKLLDVRKKRLQLKQASRSKLLEIQIEKNKQKEDVDKMENSEMIKTMKKKLQTEIKITTVVQHTFQGLILASKTNWAEDPALRETVLQLEKDLNTL

Gene
CENPH
Protein
Centromere protein H
Organism
Gallus gallus
Length
235 amino acids
Function
Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Required for the localization of CENPC but not CENPA to the centromere. It however may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
Similarity
Belongs to the CENP-H/MCM16 family.
Mass
26.8 kDa
Sequence
MAGRLSESVGSGPGAEAETAADPDAKRDVLEHLCARTHLKQLVMEFDTACPPDEGCNSGAEVNFIESAKETLEEVGKVKSAFESKALVIKRIQLMDALRKRVKENDGCARLIVETMRDIIKLNWEIIQAHQQARVIRENLNDIRRKRYFLKQAEGEKALRIFTTVRKKKEVVRMKIAEKLKFIHRNVQYERKVTTLVQNILQNIIVGCQINWAKDPSLRAIILQLEKDISIQNLL