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CEMIP

Gene
CEMIP
Protein
Cell migration-inducing and hyaluronan-binding protein
Organism
Homo sapiens
Length
1361 amino acids
Function
Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.
Similarity
Belongs to the CEMIP family.
Mass
152.998 kDa
Sequence
MGAAGRQDFLFKAMLTISWLTLTCFPGATSTVAAGCPDQSPELQPWNPGHDQDHHVHIGQGKTLLLTSSATVYSIHISEGGKLVIKDHDEPIVLRTRHILIDNGGELHAGSALCPFQGNFTIILYGRADEGIQPDPYYGLKYIGVGKGGALELHGQKKLSWTFLNKTLHPGGMAEGGYFFERSWGHRGVIVHVIDPKSGTVIHSDRFDTYRSKKESERLVQYLNAVPDGRILSVAVNDEGSRNLDDMARKAMTKLGSKHFLHLGFRHPWSFLTVKGNPSSSVEDHIEYHGHRGSAAARVFKLFQTEHGEYFNVSLSSEWVQDVEWTEWFDHDKVSQTKGGEKISDLWKAHPGKICNRPIDIQATTMDGVNLSTEVVYKKGQDYRFACYDRGRACRSYRVRFLCGKPVRPKLTVTIDTNVNSTILNLEDNVQSWKPGDTLVIASTDYSMYQAEEFQVLPCRSCAPNQVKVAGKPMYLHIGEEIDGVDMRAEVGLLSRNIIVMGEMEDKCYPYRNHICNFFDFDTFGGHIKFALGFKAAHLEGTELKHMGQQLVGQYPIHFHLAGDVDERGGYDPPTYIRDLSIHHTFSRCVTVHGSNGLLIKDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPSDRDSKMCKMITEDSYPGYIPKPRQDCNAVSTFWMANPNNNLINCAAAGSEETGFWFIFHHVPTGPSVGMYSPGYSEHIPLGKFYNNRAHSNYRAGMIIDNGVKTTEASAKDKRPFLSIISARYSPHQDADPLKPREPAIIRHFIAYKNQDHGAWLRGGDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPGGLDHSGRTLPIGQNFPIRGIQLYDGPINIQNCTFRKFVALEGRHTSALAFRLNNAWQSCPHNNVTGIAFEDVPITSRVFFGEPGPWFNQLDMDGDKTSVFHDVDGSVSEYPGSYLTKNDNWLVRHPDCINVPDWRGAICSGCYAQMYIQAYKTSNLRMKIIKNDFPSHPLYLEGALTRSTHYQQYQPVVTLQKGYTIHWDQTAPAELAIWLINFNKGDWIRVGLCYPRGTTFSILSDVHNRLLKQTSKTGVFVRTLQMDKVEQSYPGRSHYYWDEDSGLLFLKLKAQNEREKFAFCSMKGCERIKIKALIPKNAGVSDCTATAYPKFTERAVVDVPMPKKLFGSQLKTKDHFLEVKMESSKQHFFHLWNDFAYIEVDGKKYPSSEDGIQVVVIDGNQGRVVSHTSFRNSILQGIPWQLFNYVATIPDNSIVLMASKGRYVSRGPWTRVLEKLGADRGLKLKEQMAFVGFKGSFRPIWVTLDTEDHKAKIFQVVPIPVVKKKKL

Gene
Cemip
Protein
Cell migration-inducing and hyaluronan-binding protein
Organism
Mus musculus
Length
1361 amino acids
Function
Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.
Similarity
Belongs to the CEMIP family.
Mass
153.034 kDa
Sequence
MRASGRHDVSLKIVLATGCLLLANFSGASSAVATECPDQSPELQPWSPGHNRDYQVHIGHGRKLLLTSSATVHSITISGGGKLVIKDHHEHIVLRTRYILIDDGGELHAGSALCPFEGNFSIVLYGRADENILPDPYYGLKYIGVDKGGTLELHGQKKLSWTFLNKTLHPGGMQEGGYFFERSWGHRGVIVHVIDAKLGTVVHSDRFDTYRSKKESERLVQYLNAVPDGRILSVAVNDEGSRNLDDTARKAMTKLGSKHFLHLGFRHPWSFITVKGNPSSSVEDHIEYHGHKGSAAARVFKLFQTEHGEHFNVSSSSEWVQDVEWTEWFDHDKVPQSKGGEKISDLRAAYPGKICNRPIDIQATTMDGVALSTEVVYKNGQDYRFACYTRGRACRSYRVRFLCGKPVRPKLTVSIDTNVNSTILSLVDNVRSWRPGDTLVVASTDYSMYQAEEFRVLPCKACTSTQVKVAGKPQYLHIGEEIDGVDMRAEVGLLTRNIVVMGEMEDRCYPYTNHICDFFDFDTFGGHIKFALGFKAAHLEGVELKYMGQQLVGQYPIHFHLAGDLDEQGGYDPPTYIRDLSIHHTFSRCITVHGSNGLLIKDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPSDRDSRMCKVITEDSYPGYIPKPRQDCNAVSTFWMANPNNNLINCAAAGSEETGFWFIFHHVPTGPSVGMYSPGYSEHIPLGKFYNNRAHSNYRAGMIIDNGVKTTEASAKDKRPFLSIISARYSPHQDADPLKPREPAIIRHFTAYKNQDHGAWLRGGDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPGGLDHSGRTLPIGQNFPIRGIQFYDGPINIQNCTFRKFAALEGRHTSALAFRLNNAWQSCPHNNVTNIAFEDVPITSRVFFGEPGPWFNQLDMDGDKTSVFHDLDGSVSEYPGSYLTKDDNWLVRHPDCINVPDWRGAICSGRYAQMYIQAYKSSNLRMKIIKNDFPSHPLYLEGALTRSTHYQQYQPVITLQKGYTIHWDQTAPAELAIWLINFNKGDWIRVGLCYPRGTTFSILSDVHNRLLKQTSKTGTFVRTLQMDKVEQSYPGRSHYYWDEDSGLLFLKLKAQNEREKFAFCSMKGCERIKIKALLPRNAGISDCTATAYPRFTERAIVDVPMPRKLFGAQLKTKDHFLEVKMESSRQHFFHLRNDFAYIEVDGRRYPCSEDGIQIVVIDGSRGHVVSHGSFRNAILQGIPWQLFNYVAAIPDNSIVLMASKGRYITRGPWTRVLEKLGADKGLKLKEKMAFVGFKGSFRPIWVTLETEDHKAKIFQVVPIPVVRKKKL