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CDNF

Gene
CDNF
Protein
Cerebral dopamine neurotrophic factor
Organism
Homo sapiens
Length
187 amino acids
Function
Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
Similarity
Belongs to the ARMET family.
Mass
20.964 kDa
Sequence
MWCASPVAVVAFCAGLLVSHPVLTQGQEAGGRPGADCEVCKEFLNRFYKSLIDRGVNFSLDTIEKELISFCLDTKGKENRLCYYLGATKDAATKILSEVTRPMSVHMPAMKICEKLKKLDSQICELKYEKTLDLASVDLRKMRVAELKQILHSWGEECRACAEKTDYVNLIQELAPKYAATHPKTEL

Gene
Cdnf
Protein
Cerebral dopamine neurotrophic factor
Organism
Mus musculus
Length
187 amino acids
Function
Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
Similarity
Belongs to the ARMET family.
Mass
21.032 kDa
Sequence
MRCISPTALVTFCAGFCISNPVLAQGLEAGVGPRADCEVCKEFLDRFYNSLLSRGIDFSADTIEKELLNFCSDAKGKENRLCYYLGATTDAATKILGEVTRPMSVHIPAVKICEKLKKMDSQICELKYGKKLDLASVDLWKMRVAELKQILQRWGEECRACAEKSDYVNLIRELAPKYVEIYPQTEL

Gene
Cdnf
Protein
Cerebral dopamine neurotrophic factor
Organism
Rattus norvegicus
Length
187 amino acids
Function
Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra.
Similarity
Belongs to the ARMET family.
Mass
21.361 kDa
Sequence
MRCTSPAALVTFCAGLWISNHVLAQGLEAGVRSRADCEVCKEFLNRFYNSLLTRGIDFSVDTIEEELISFCADTKGKENRLCYYLGATKDSATKILGEVTRPMSVHMPTVKICEKLKKMDSQICELKYEKKLDLESVDLWKMRVAELKQILHSWGEECRACAEKHDYVNLIKELAPKYVETRPQTEL