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CDK10

Gene
cdk10
Protein
Probable cyclin-dependent kinase 10
Organism
Dictyostelium discoideum
Length
366 amino acids
Similarity
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Mass
41.964 kDa
Sequence
MRSVLSFEKLDSIGEGTYGIVSKGRDKETGRIVALKKVKIGQQDKDGIPLTSLREIQILKEIKHPNIVSLLEVVIGSTGDKIYLVFEYLEHDVASLIDNINKPFKLSEIKCFLLQLLRAVEYLHSHWIIHRDLKCSNLLYGNNGNLKLADFGLARKFGYPIESITPCMVTLWYRSPELLLGCQKYSTAVDLWSIGSIFGELLIGRPLITGNNEVDQIMRIFNLLGEPNEQIWPGFSSLPNFKRLNNIPHQPYNNLRELVPTISDTAFDLLNQLLTYDPTKRITASDAIKHPFFYENPFPQSIEMMPKFPTISKSFKNQNKKQNNNFNNFVQNNQTNQNNQTNQNNQTNQNNKTSQNNNMDSYKYSK

Gene
CDK10
Protein
Cyclin-dependent kinase 10
Organism
Bos taurus
Length
361 amino acids
Function
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling.
Similarity
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Mass
41.047 kDa
Sequence
MGEPEPEQIRLKCVRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTHTDEIVALKKVRMDKEKDGVPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGIPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHKPLLPGTSEIHQVDLIVQLLGTPSENIWPGFSQLPLASQYSLRKQPYNNLKHKFPWLSEAGLRLMNLLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRATPATSLGTESQSRRGRP

Gene
CDK10
Protein
Cyclin-dependent kinase 10
Organism
Homo sapiens
Length
360 amino acids
Function
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747).
Similarity
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Mass
41.038 kDa
Sequence
MAEPDLECEQIRLKCIRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP

Gene
Cdk10
Protein
Cyclin-dependent kinase 10
Organism
Mus musculus
Length
360 amino acids
Function
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling.
Similarity
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Mass
40.961 kDa
Sequence
MAEVDLESDQIRLKCIRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIMLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHKPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLAGQYSLRKQPYNNLKHKFPWLSEAGLRLLNFLFMYDPKKRATSGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPAAAEGQSKRCRP

Gene
Cdk10
Protein
Cyclin-dependent kinase 10
Organism
Rattus norvegicus
Length
358 amino acids
Function
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling.
Similarity
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Mass
40.634 kDa
Sequence
MSQCQIWVRHHLCCSFQIPTLAASLFQLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCILLQVLRGLQYLHRSFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHKPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLAGQYSLRKQPYNNLKHKFPWLSEAGLRLLNFLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPAATEGQSKRCRP