cdc5l

Cell division cycle 5-related protein

805 amino acids

DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. May also play a role in the response to DNA damage (DDR).

Belongs to the CEF1 family.

91.94 kDa

MPRIIIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEDEKLLHLAKLMPTQWRTIAPLIGRTAAQCLERYEYLLDQAQAKEGDKDEGDDPRKLRPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIDIRKHRKKKRGVDYNAEIPFEKKPASGFYDTSDENLPDYQPDFKRLRQDHLEGKMRDEIEQQERKKDKERMKKKKESDLPGAVMQINKMNNPDHVKKRSKLVLPKPQISDGELEEIVKMGYASEVARASVENGGQASDALLSEYSVTPAINKALRTPRTPAEQDTVLQEAQNILALSNVDTPLKGGLNTPMHESDFQGVTPRQQAIQTPNMLLSTPYRTPGEGSGSTPRQGMTPRGAIGTPSQRSVRDKLNINPEDAVMEEYESECAAKQQQSEAKEQLLAGLASLPAPSNDFEIVLPETPAEASEEHKPMDFVEDAADIDERALALRAKQEELERRRRSQAVQRELPRPSNVNTSVLRPTNVEPPLSALQMAEELIKKEMIVMLRNDIINHPTSQQIESLTNKKTRNAAQAVITGNRAALERDPMENFTDEELSSAKNLLRQEMDFVKSKMAHSDLPLEAYSKVWEECYAQVLFLPSQQRYTRAAMASKKDRLESLEKRLELNRYQMTEDAKKAAKIEKKLKVLLGGYQTRAVGLTKQLSDLHEQLEQSQVEMTTFQALRNQELQAIPKRLEALKEDVQRQTEREKQLQAQYSELLYERDSLLSKLQI

CDC5L

Cell division cycle 5-like protein

802 amino acids

DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).

Belongs to the CEF1 family.

92.27 kDa

MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKAAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKKKRGVDYNAEIPFEKKPALGFYDTSEENYQTLDADFRKLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEIARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPASQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSHGSEGLTPRSGTTPKPVINSTPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKTVGFGTNNAEHIAYLEHNPYEKFSKEELKKAQDVLVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPGQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAYLELRTFEELKKHEDSAIPRRLECLKEDVQRQQEREKELQHRYADLLLEKETLKAKF

CDC5L

Cell division cycle 5-like protein

802 amino acids

DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28502770, PubMed:28076346, PubMed:29361316, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811).

Belongs to the CEF1 family.

92.251 kDa

MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKAAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEIARQTAEESGITNSASSTLLSEYNVTNNSVALRTPRTPASQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEGLTPRSGTTPKPVINSTPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKTVGFGTNNSEHITYLEHNPYEKFSKEELKKAQDVLVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPGQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRLECLKEDVQRQQEREKELQHRYADLLLEKETLKSKF

Cdc5l

Cell division cycle 5-like protein

802 amino acids

DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).

Belongs to the CEF1 family.

92.19 kDa

MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKKKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPASQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEGLTPRSGTTPKPVTNATPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGFATNNSEHITYLEHSPYEKFSKEDLKKAQDALVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPAQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRLECLKEDVQRQQEREKELQQRYADLLMEKETLQAKF

Cdc5l

Cell division cycle 5-like protein

802 amino acids

DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).

Belongs to the CEF1 family.

92.218 kDa

MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKKKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPASQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEGLTPRSGTTPKPVTNATPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEKELEEREMDDTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGFATNNSEHITYLEHSPYEKFSKEDLKKAQDVLVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPAQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLLKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRLECLKEDVQRQQEREKELQQRYADLLMEKETLQAKF

cdc5l

Cell division cycle 5-like protein

800 amino acids

DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. May also play a role in the response to DNA damage (DDR).

Belongs to the CEF1 family.

92.121 kDa

MRNVKGGVWKNTEDEILKVAIMKYGLNQWARISSLLTRKSPAQCKARWHEWLDPSIKKTEWSKEEEEKLLHLAKIFPSQWKTIAPLVGRTASQCLERYNRLLDEVQRQQDNENGGGSGGGGTTTTTTTTTGENDPRRLRMGDIDPTPETKPAKPDPIDMDEDEKETLSEAKARLSNTQGKKEKRKFREKQLEEARRLAFLQKKRELKAAGINYNPKKKGKEKSWDISKEIPFYLKPKAGFYDVPDEELRDEPNKDASFIGKRVDQIENPNYLQRQEKLNKLEDIKKSKKEIFNLPQLISETSKSNDVEHSIKRTKLQLPEPQLTDDDIQEISDYEKLNGSGSGGGSGGVGVGEFPLPAPRTASISSTAANNNTNNIRTPMKQDTIMSEAQNLLALSNAQTPLKGGAGPNVSQTPLPKSVNNSTPFRTPNPLANQTPTQHNKKQSLNDSNEFAIEDKFKRQQGKNQLLSNLKNLPSPTIEYKLELPSELPTIEDDTTLELDNSEIHIREQQQLKHKEQFKLRNRSTVLKRNLPRSRNLFPINKNNNNNNNNNINQDELRILKEINRIISHDNKTFPNDSITPSSTFDDDDDDDNHHHHHDDIDNNSINDNDEKYENYDYFTNTELEFADKLIRDEIEQIKQELKQPLPSSNEILEEIDQIRSQFIYLPKENQFIEKSNANQTQLIENLQFEYDKTLNKIKNSSMKSVNLEKKLNIYNGGYQNRSNTIIKNIDDMFDQLEQSEIEYQCFVALKNNESIQMEKRLKSIENQVYDQCEIESRLQQKYAQLLNEKNLLKKKLSIF