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CDC3

Gene
CDC3
Protein
Cell division control protein 3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
520 amino acids
Function
Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring approximate 15 minutes before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many proteins bind asymmetrically to the septin collar. The septin assembly is regulated by protein kinases GIN4 and/or CLA4. May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage. Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.
Similarity
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
Mass
60.054 kDa
Sequence
MSLKEEQVSIKQDPEQEERQHDQFNDVQIKQESQDHDGVDSQYTNGTQNDDSERFEAAESDVKVEPGLGMGITSSQSEKGQVLPDQPEIKFIRRQINGYVGFANLPKQWHRRSIKNGFSFNLLCVGPDGIGKTTLMKTLFNNDDIEANLVKDYEEELANDQEEEEGQGEGHENQSQEQRHKVKIKSYESVIEENGVKLNLNVIDTEGFGDFLNNDQKSWDPIIKEIDSRFDQYLDAENKINRHSINDKRIHACLYFIEPTGHYLKPLDLKFMQSVYEKCNLIPVIAKSDILTDEEILSFKKTIMNQLIQSNIELFKPPIYSNDDAENSHLSERLFSSLPYAVIGSNDIVENYSGNQVRGRSYPWGVIEVDNDNHSDFNLLKNLLIKQFMEELKERTSKILYENYRSSKLAKLGIKQDNSVFKEFDPISKQQEEKTLHEAKLAKLEIEMKTVFQQKVSEKEKKLQKSETELFARHKEMKEKLTKQLKALEDKKKQLELSINSASPNVNHSPVPTKKKGFLR

Gene
CDC3
Protein
Cell division control protein 3
Organism
Candida albicans
Length
416 amino acids
Function
Plays a role in the cell cycle. Involved in the formation of the ring of filaments in the neck region at the mother-bud junction during mitosis.
Similarity
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
Mass
47.841 kDa
Sequence
MSTNIKIIKKVLNGYVGFANLPKQWHRKSIRRGFSLNIMAIGESGLGKATLINTLFNRDIITSQHDSDEFDEGEEEDVSVKIKSTQAEIEEDGVKLKVSVITAPGFGESINNVEAWKPIVDEINSRFDSYLEAESRINRTAVVDNRVHAFLYFIEPTGHSLRALDIALMKQVHEKVNLIPVIAKSDTLTDEEILEFKHRILADISHQGIKIFKPTDFEYDEEESANTRSIIDSFPFAVVGSTNEVQTPDGRLVRGRKYPWGVIEVDNENHNDFVKLRQLLVRNFLEELKEHTANVLYENYRTEKLKRMGIEQDNTVFREFDPAAKQEEERALHEAKLAKMEAEMKSVFQQKVSEKEKKLQRSEADLFARHKEMKDKLTKQIKLLEEKKAQLEKQKLLPQDPPAQPAPQKSRKGFLR

Gene
CDC3
Protein
Cell division control protein 3
Organism
Encephalitozoon cuniculi (strain GB-M1)
Length
371 amino acids
Function
Septins are GTPases involved in cytokinesis. The septins localize to the site of cleavage and act as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Septins are also involved in cell morphogenesis, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation (By similarity).
Similarity
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
Mass
42.68 kDa
Sequence
MAQKGIGVSNLPNVKYRSFCKAGIDFNIMTVGSNGLGKSSFINQMLGDSILSSDPFLKPEDGHHSNETVRALDEDIVDDPESKYFHRNSLINIQISKFFVMENDFQTRVTVTEVDGVGDGVCNEGCWDPIVELIQDNFRDYLDQERKNVRSLIKDKRIHICLYFLEPNPSHVSLVDIRTMKEISKICNLIPVVGKSDLLSDSEREECRNRIVEVLSMENIDVFRLDILEKEKISRTESPFFIIAKNVNSGDSSGHNREYPWGTMFPEKVESNDFYFLVDSLIAKNLIRLVETTEVFYDEYKTREIGLSIASKPGALGEDDRRLTKEIQKKIKEDERTIVELRQKLIEKRKYYESKMLEITSKYSNEKINSS

Gene
cdc3
Protein
Profilin
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
127 amino acids
Function
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. In S.pombe, it is essential for cytokinesis.
Similarity
Belongs to the profilin family.
Mass
13.411 kDa
Sequence
MSWQAYVDTSLLGTGKIDRAAIVSRAGDSVWAASAGFNLSPQEIQGLAAGFQDPPSMFGTGIILAGQKYITIRAEGRSIYGKLQKEGIICVATKLCILVSHYPETTLPGEAAKITEALADYLVGVGY