Protein
Cell division cycle protein 123
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Function
Regulates the cell cycle in a nutrient dependent manner. Accumulates in presence of nutrients and directs the destabilization of DMA1 and DMA2, whose accumulation results in a G1 block. Regulates also the abundance of GCD11 an essential component of the translational initiation factor 2.
Similarity
Belongs to the CDC123 family.
Sequence
MSSQEYTTFIDIPVTRAQVEHCSYSFWSSLYPKYVPKSIVLKSLPKKFIQYLEQDGIKLPQEENSRSVYTEEIIRNEDNDYSDWEDDEDTATEFVQEVEPLIDFPELHQKLKDALNELGAVAPKLNWSAPRDATWILPNNTMKCNEVNELYLLLNASNYIMHDLQRAFKGCVDGDDIKGLKFDLVLRQWCDMNPALEFRVFVKNAHIVGATQRDLNYYDYLDELSDTFKDLIDEIVHDVVLPKFPDKSFVLDVYIPRPFNKIFIVDINPFARKTDSLLFSWNEIAAIAPPKNDVEDYELRLVTRHNTGRFASKEHSENHVPQDLVEASLNPEAIRELTQKWKELLSQQAKEESSDSENET