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CD59

Gene
CD59
Protein
CD59 glycoprotein
Organism
Saimiri sciureus
Length
131 amino acids
Function
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts at or after the C5b-8 stage of MAC assembly.
Mass
14.355 kDa
Sequence
MGIQGGSVLFGLLLVLAVFCHSGNSLQCYSCPLPTMESMECTASTNCTSNLDSCLIAKAGSGVYYRCWKFDDCSFKRISNQLSETQLKYHCCKKNLCNVKEVLENGGTTLSKKTILLLVTPFLAAAWSRHP
Protein
CD59 glycoprotein: CD59

Gene
CD59
Protein
CD59 glycoprotein
Organism
Aotus trivirgatus
Length
128 amino acids
Function
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts at or after the C5b-8 stage of MAC assembly.
Mass
14.201 kDa
Sequence
MGIQGGSVLFGLLLVLAVFCHSGNSLQCYSCPYPTTQCTMTTNCTSNLDSCLIAKAGSRVYYRCWKFEDCTFSRVSNQLSENELKYYCCKKNLCNFNEALKNGGTTLSKKTVLLLVIPFLVAAWSLHP
Protein
CD59 glycoprotein: CD59

Gene
CD59
Protein
CD59 glycoprotein
Organism
Callithrix sp.
Length
128 amino acids
Function
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity).
Mass
14.21 kDa
Sequence
MGIQGGSVLFGLLLILAVFCHSGHSLQCYSCPYSTARCTTTTNCTSNLDSCLIAKAGLRVYYRCWKFEDCTFRQLSNQLSENELKYHCCRENLCNFNGILENGGTTLSKKTVLLLVTPFLAAAWSLHP
Protein
CD59 glycoprotein: CD59

Gene
CD59
Protein
CD59 glycoprotein
Organism
Chlorocebus aethiops
Length
128 amino acids
Function
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity).
Mass
14.007 kDa
Sequence
MGIQGGSVLFGLLLVLAVFCHSGHSLQCYNCPNPTTDCKTAINCSSGFDTCLIARAGLQVYNQCWKFANCNFNDISTLLKESELQYFCCKKDLCNFNEQLENGGTSLSEKTVVLLVTLLLAAAWCLHP
Protein
CD59 glycoprotein: CD59

Gene
CD59
Protein
CD59 glycoprotein
Organism
Homo sapiens
Length
128 amino acids
Function
The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
Mass
14.177 kDa
Sequence
MGIQGGSVLFGLLLVLAVFCHSGHSLQCYNCPNPTADCKTAVNCSSDFDACLITKAGLQVYNKCWKFEHCNFNDVTTRLRENELTYYCCKKDLCNFNEQLENGGTSLSEKTVLLLVTPFLAAAWSLHP
Protein
CD59 glycoprotein: CD59

Gene
CD59
Protein
CD59 glycoprotein
Organism
Macaca fascicularis
Length
128 amino acids
Function
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity).
Mass
14.008 kDa
Sequence
MGIQGGSVLFGLLLVLAVFCHSGHSLQCYNCPNPTTDCKTAINCSSGFDTCLIARAGLQVYNQCWKFANCNYNDISTLLKESELRYFCCKKDLCNFNEQLESGGTSLSEKTVVLLVTPLLAAAWCLHP
Protein
CD59 glycoprotein: CD59

Gene
CD59
Protein
CD59 glycoprotein
Organism
Pongo abelii
Length
128 amino acids
Function
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity).
Mass
14.02 kDa
Sequence
MGIQGGSVLFGLLLILAVFCHSGHSLQCYSCPNPTADCKTAVNCSSGFDACLITKAGLRVYNQCWKFEHCTFNEVTTRLKESELTYHCCKKDLCNINEQLENGGTSLSEKTVLLLVTPFLAAAWSLHP
Protein
CD59 glycoprotein: CD59

Gene
CD59
Protein
CD59 glycoprotein
Organism
Papio sp.
Length
126 amino acids
Function
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity).
Mass
13.716 kDa
Sequence
MGIQGGSVLFGLLLALAVFCHSGHSLQCYNCPNPTTNCKTAINCSSGFDTCLIARAGLQVYNQCWKFANCNFNDISTLLKESELQYFCCKEDLCNEQLENGGTSLSEKTVLLLVTPLLAAAWCLHP
Protein
CD59 glycoprotein: CD59

Gene
Cd59
Protein
CD59 glycoprotein
Organism
Rattus norvegicus
Length
126 amino acids
Function
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts at or after the C5b-8 stage of MAC assembly.
Mass
13.79 kDa
Sequence
MRARRGFILLLLLAVLCSTGVSLRCYNCLDPVSSCKTNSTCSPNLDACLVAVSGKQVYQQCWRFSDCNAKFILSRLEIANVQYRCCQADLCNKSFEDKPNNGAISLLGKTALLVTSVLAAILKPCF
Protein
CD59 glycoprotein: Cd59

Gene
CD59
Protein
CD59 glycoprotein
Organism
Oryctolagus cuniculus
Length
124 amino acids
Function
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore.
Mass
13.87 kDa
Sequence
MTSRGVHLLLRLLFLLAVFYSSDSSLMCYHCLLPSPNCSTVTNCTPNHDACLTAVSGPRVYRQCWRYEDCNFEFISNRLEENSLKYNCCRKDLCNGPEDDGTALTGRTVLLVAPLLAAARNLCL
Protein
CD59 glycoprotein: CD59

Gene
CD59
Protein
CD59 glycoprotein
Organism
Sus scrofa
Length
123 amino acids
Function
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore.
Mass
13.79 kDa
Sequence
MGSKGGFILLWLLSILAVLCHLGHSLQCYNCINPAGSCTTAMNCSHNQDACIFVEAVPPKTYYQCWRFDECNFDFISRNLAEKKLKYNCCRKDLCNKSDATISSGKTALLVILLLVATWHFCL
Protein
CD59 glycoprotein: CD59

Gene
CD59
Protein
CD59 glycoprotein
Organism
Ovis aries
Length
27 amino acids
Function
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding, in a species specific manner, to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore.
Mass
3.027 kDa
Fragment
single
Sequence
LQCYSCINQVDCTSVINCTXNQDACLY