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CCL21

Gene
CCL21
Protein
C-C motif chemokine 21
Organism
Homo sapiens
Length
134 amino acids
Function
Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Similarity
Belongs to the intercrine beta (chemokine CC) family.
Mass
14.646 kDa
Sequence
MAQSLALSLLILVLAFGIPRTQGSDGGAQDCCLKYSQRKIPAKVVRSYRKQEPSLGCSIPAILFLPRKRSQAELCADPKELWVQQLMQHLDKTPSPQKPAQGCRKDRGASKTGKKGKGSKGCKRTERSQTPKGP

Gene
CCL21
Protein
C-C motif chemokine 21
Organism
Macaca mulatta
Length
131 amino acids
Function
Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity).
Similarity
Belongs to the intercrine beta (chemokine CC) family.
Mass
14.368 kDa
Sequence
MAQSLALSLLILVLAFGIPGTQGSDGGAQDCCLKYSQRKIPAKVVRSYRKQEPSLGCSIPAILFLPRKRSQAELCADPKELWVQQLMQHLDKTPTPRKPVQGCRKDRGVPKNGKKGKGCKRTEQSQTPKGP