Protein
Daple-like protein
Function
Positive regulator of Wnt signaling, acting synergistically with dvl2/dsh. Functions upstream of ctnnb1/beta-catenin in the canonical Wnt pathway, and also activates jnk in the Wnt/planar cell polarity (PCP) pathway.
Similarity
Belongs to the CCDC88 family.
Sequence
MDTTISQQMDHFLESPLVTWVKTFGPCGNENESKLAMYMELVDGVFLNKIMVQIDPRPSNQRVNKHVNNDVNRRVQNLTILVRHIKAYYQEVLQQLIVMNLPNVLLISKDPLTDKSMEELKKILLLMLGCAVQCERKEEYIERIKQLDIETQAGIVSHIQEVTHNQENVFDLQWLELSDMAPEELDSLSRNMALHLKRLIDERDECKEVIVDLTQERDYLQFQNHPSPVKSSSPDTSANMVSHLSSEDKKHLAVELAESKAKLRRIRQELEEKSELLLDTKHEVERLNLELQKIKQENFQLASEARTARTYRDEIDSLKERASKVDRLENELARCKEKLHDVDFYKARMDELREDNMILIETKSMLEEQLAAARTRTDKLHELEKENLQLKSKIHDLELDRYSDKNRIEELLEENMVLEIAQKQSMNESAQLGWELDQLSKSTDLSDARKSFVFELNETTSSKILKLEKENQSLQNIIQDLREASLTLEEGNLKGQEWEKENQQLSKKIENLNQQIERERQSSLDLESLSEDLLKEKDQLSQALENIKSQKERQIKELEQENKHLIQTLEAVRQRSQVSTEARVKDIEMENRILHETIKDTSSKMNELEYEKKQLQKAFDQSKEQVEKLDKMEKEVHRLEKQNEILTKKVTSIKIVEEKMQGLEKENEVLEGENIVLKKSLDTLQNVTIKLEVLESENKQLDEENLELRRAVEAMRFSCAKSTQIERENNELQKEKEELQKNVELLKALGKKSERLEVSYQGLNDENWRLQQMLDTGNKKINDLEKELHDTEKENKDLQRTLEEMKICNKRLERMEEENKAKEQEMVQLEKDNKILQKESKRLWQQVELKDAILDDNTVKLADLEKENRALEKEISKLRDLSTKTRDLERENKDLLQQMTVDKRTLATLREDLVLEKLKTQQMSSELDKLSLELEKIGLNKESMLQDENSNAEKKYKLLENKIESTLKTTLAVKENKIVALEMKIEETSSLNQQLQNELNSIKKDIIASKENLRGAAHNSYTQLSSKQDCNSQINGQRETTVELLKFKDRTIELERNNAALQAEKKLFREQLQHLESHNLNLSSQMGTLQKQVTFLQEHNTALQTQTANLQVENATATSQVASLKSQISQFQNQLSARESENEILQQQKEHLRVTHESLLQDHEQLGSLYERQSAEYEGMISQHSSLKSQYKSLEQAHRSLEESYSTLIKHKKELEDLDAVLKKEQDVLQQERRKNFVAMEENQKLKTDLERLNFLHGELQTEYSSLHKHTKEVKTSLNNAQMELNRWQARFDELKEQHQTMDISLTKLDNHCELLTRLKSNLEEENHHLLSQIQMLSQQNQMLLEQSMETKEQYHEEQKQYIDKLHDLRRQKEKLEEKIMDQYKFYDPTPKKKSHWSGAKAIAKLIKPKKEPSRESVKSPTDVQSKTMDNAEMAASPSSMRPLRLQQESLDNSSLGSDEKGSPKVLASKVLVEVAQRQHRMSYHGSSSEQTDGPEHLSRSRRMESGSRAFSTSTIHLTAPAHNAKVPHLSRPKGYNSDDNQSDQLHEAESNAGSSRVPWTSSLEVSRSASNSSSPLTLKGRPESVSSEDMIPTKDIATLSRESNLYHPNAVMLGATKNRESPVNRNSLHLYDYPEKKNSSRTPTRPRPGSPGSEMVTLEEFLQESSRQSPPSRRHSLNDSELITLHQFLFEAETLHPSSQSPSPTLHLKDPSQTAVPKSLPSAENCEWRKRADRASRRAASLYIPRDMVTNRDDMLGDLFKKTEDPPDIRSPMSELIFKDAAQMPTSYVSPTVKVTGNTTKPGQYVKPHPRQLDAPLNVTSSLLHQANVYSATSSSQSPEPQALSPHGAMGSRGNSLSRAFSLASADLLKENGPEVVMQEKSDVETPVGKDFGRYMIRSSTPLGSQSSLREKPQSARMQHMLRGDDRQYRSLDSRRLSLALPKEETTPPQPAPSASSLQQHYTLGHGAIRGKPKLLSRSGEVALVSPVRPISSIPELETTQGLASAGPGKSRSTSPDCSPAPVCEEEPNKSETLKSTPASPDPSADPQTVWYEYGCV