ccdc39

Coiled-coil domain-containing protein 39

947 amino acids

Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.

Belongs to the CCDC39 family.

108.989 kDa

MSSALLEEVGWDADFAIPVANAENKALEEQIRKKQKDILNLDNKLNKHKDVINALTEHLKNLKQEVSHNQALCKAKEKETESEVHLKALAERETGRLKQEITRLESQLTTLNEKKNAQENSIFKATQKIDELTSQLNWDQQTLEAFLQESAHKDEDTMAIIKYAKQDERKIKELTLNIEKLTLESNQKRKTLDNELTETVTSQIALDKTAESFRQAHTERQELISQWENTIEQMRKRDQDIQQCAMMLAELNQTIREKNDLIKERKDFLEREIENNKELERNIGTVERQAFRLRQQLQEEEKNQRRLQDEVEVLKGTVDRTATDVETSRSQLSSMKKDIQDKTTKVEEAQLHNAALEEKLRMVTEAVLNGEEQAAQMEQLLREQEQNIKEIDSQLLRQKELLFKKSQEVQALRDKEKNVTAEICATRTALSNLDSKLRKLDQNFLQQQMIISNQDFQIQMLERKTLHLQGKVNTEEKKALEKKVADLAASLEEKKKTAANLNKQLKKLQDDIRCIKKDTEKIGAEKTNLSTKIQEVELFIETSEKERKKSRLKKQDSMVEKGLLKMEVQRLRNLLYDRADGVLTLEKRRLQLQTAMKEREEEIRVHREMLNKQVKLTEQERQGLSAAVNEAMSKIDKQRKRYEVLSVSLAPPEGEEDKSQAYFIIKAAQEKEELQRKGDELDAKIRKTEKEIHALENTLQVVNNCNSTHRKALTKVTESSPAHQEKLKLEEQRRAAEEKYKYKRRQTQELQEDIESMSNTLEGLLQEEKVLNEGIERTQAHVLSLNKDILSQEEKINRAVKQCAKYTKEIRSGKQSTEKTFEERDIELRELRDFNKSINKMLLDAMEGNPELSSILQIHFTQAGLSLPSPSSTPSSRLSSKPSSARSSASLHRSSNLSASSSPRSQSVSSPQMKTVDLGLGLSVTSPRGSQPSSAGSSRSSSKCKSP

ccdc39

Coiled-coil domain-containing protein 39

945 amino acids

Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.

Belongs to the CCDC39 family.

110.476 kDa

MNRKVLDELRWDDGYAIPVANAENKTLEEEMQKKEKEKIQLSNQVKGFEERIQAMADHLRNVRQELTYTQSLVRARENETESEEHFKTLSEREIGRLKQEIQRLENELVSLREKKNSHENNIFKTTQKLENLKRQLNWDQQTLEAWLEESARKDEDSMAIQKYSQKDDGKIKELSLLIEKLTLEAGQKRKLMDNELTETITAQIELDKTAEDFRKAHTERQQLISQWESTIGQMQKRDRDIDHCAMLLAQVKQELREKESIIKEKIQFLQSEIDNNKEYEKKISAAERQAAKLRLELQEQEIIRGRLQDELDSLKGVVDRTASDLETMRTEVTSLKKDIRNRQNRLQMAQEYNDGLSDKLNFVTESALSLEERALRMEEMFKEQEKTVKDLEVQLKQIREILFKKSQELHECKAKEKDVIAEINGGQVTLKNLNSQLQKLDSHALKQQGIMYNQDFQIQQLERRLSRLKGEVNTDEKQALEMRVSQLTKVFEERRAALKLLNTQHKKLQGDVRYIKRELEKTGQEKGDLISKKEEFNLFNMMSEKTLKKIKASKQDLMVEDNILKLEIKRLRDMLYSKADDVFSLEKRKLQLQTAMKERTEEISVHKEMLKSHIRYVDQERQNISSQLHERLAKVEKMRKRFEILTIAMMPPEGEEEKSQAYYVVKAAQEKEELQRVGDDLDGKIRKAEKEIRALENTLRVINGCNTSFKKSFSKITETSEEYDEKVQLEEEKKAAEEKHRYKQRQIRELQEDTQVMKNTFDSMINEELSYQEKAKELLPAITQLNKETEDQKQKLERVLKQYSKLSKHVRNAKKSKEETQEEKDINVRDLRDFNQSLNKMLAQAMEKNPDLATALQLYFHQFGLEIPTIGSTPGSYSSRSSSSRSSTISVRSGTSRISVNSGQSPRIKVVDLGLPPACPSSNVSSARSSRTSSRSGSSKSQKQE

CCDC39

Coiled-coil domain-containing protein 39

942 amino acids

Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.

Belongs to the CCDC39 family.

110.372 kDa

MSSEFLAELRWEDGFAIPVANEENKTLEEQLSKLQDERSSMQDQLRDYEDRINAMTSHFKNVKQEFLFTQSLCKARDHEIESEEHFKMIAERELGRVKDEIQRLENEITSIREKKNDKENSIFKTTQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTVECNQRRKVLDNEFAETLSVQLELDKAAQDFRKIHNERQKLILQWESTIEQMQKRDKDIDNCAVALARIKQEIREKENLVKEKIKFLENEIGNNTEYEKKISVADRKVLKCRTEYQRHEANRIQLKDELDSLKATVNRSSSDLEALRKNISKVKMDINEETARLGKIKNHNQIVRKKLKEITEKTMSVEEKATNLEDMLREEERGVKEVEVQLNIVKDVLFKKVQELQTETMKEKALVSEIEGTRSSLKHLNHQLHKLDFETLQQQEIMYAQDFYIQQVERRMSRLKGDINSEEKQALEAKTVELQKTLEEKKSALCLLETQIKKLHNDLYFTKKSNSKYRDEKQSLMTKINELTLFNDRSEKELTKAKALKQDLMIEDNLLKLEVKRTRELLHSKAEEVLSLEKRKQQLHTAMEERTEEIKVHKTMLASQIRYVDQERQNVSAEFHERLSKIDKLKNRYEILTVVMLPPEGEEEKTQAYYVIKQALVNNQMEKTGRSYEEEYSFVPMRIYDLVNQVQEINAWCCMSVPRSFQKVTPSSAEYEVKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLTVIEHLTNNVKEKVTEKQAYVLQLNRETEEQKPKLERVTKQCAKLTKEVRLLKDTKDETLEEQDIKLREVKQLHKIIDEMIVDITQENAEIGVILQTYFQQSGLELPTTSTKGSRHSSRSPSQTSLLSARSSKSTSTSASQTSIKVLELNFPASPLTGSTSRPTSASSASSTGKSRKTNK

CCDC39

Coiled-coil domain-containing protein 39

941 amino acids

Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131972). Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly (PubMed:21131972).

Belongs to the CCDC39 family.

109.901 kDa

MSSEFLAELHWEDGFAIPVANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRIILQTYFQQSGLELPTASTKGSRQSSRSPSHTSLSARSSRSTSTSTSQSSIKVLELKFPASSSLVGSPSRPSSASSSSSNVKSKKSSK

CCDC39

Coiled-coil domain-containing protein 39

939 amino acids

Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.

Belongs to the CCDC39 family.

110.367 kDa

MSSELLEELHWDDGFAIPVANEENKMLEDQLSKLQEERASLQDQLRDYEDRINAMTSHFKNVKQEFSFTQSLCKAREHEIESEEHFKIIAERELGRIKDEIQRLENEMTSIREKKSDKENNIFKTTQKLDGLKCQINWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQRRKVLDNELTETLSAQLELDKAAQDFRKIHNERQELIKQWENTIEQMRKRDRDIDNGALALARIKQELREKENLVKEKIKFLESEIGNNTEYEKRISVADRKLLKCRTEYQHHETNRNQLKDELDSLKATVNRSSSDLEALRKNISKIKKDIQEETARLQKIKNHNQSVKKKLKQITEKTMSVEEKATNLEDMLREEEKSVKEVEVQLNIVKDVLFKKVQELQTEAMKEKAVVSEIEGTRSSLKHLNHQLHKLDFETLKQQEIMYSQDFYIQQVERRMSRLKGEINSEEKQALETKIVELKKILEEKKSTFDLLESQIKKLHNDLYFIKKSNSKNCDEKQFLMTKVNELNLFNDRSEKELNKTKALKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLHTAMEERMEEIKVHKTMLASQIRYIDQERQNLSAEFHERLSKIDKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDSLDAKINKAEKEIYALENTLQVLRSCNNNYKQSFQKITPSSDEYELKIQLEEQKRAIDEKYRYKQRQIRELQEDIQSMENTLEVIEHLTNNVKEKLSEKQAYSSQLNRETEEQRPKLERVTKQCAKLTKEIRLLKDTKDETLEEQDIKLREVKHFHKIIDEMLAEVTEENAEIHIILQTYFQQNGLELPTAGTKGSRQSSRSPSQTSLLSARSTTSVASQTSIKVLELNFPASSSVTGNISRPASATTIPSNGKNKKGSK

Ccdc39

Coiled-coil domain-containing protein 39

937 amino acids

Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.

Belongs to the CCDC39 family.

110.072 kDa

MCSEFLSELHWEDGFAIPVANQENKILEDQLAKLREEKSNLQDQLHDYEERINSMTSHLKNVNQEFLFTQSLYKARESEIESEEHFKAIAERELGRVKNETQLLEKEMAIIRERKSQMENNIFKTTQKLDDLKCQMNWDQQALEAWLEESAHKDSDSLTLQKYSQQDDNKIRALTLQLEKLTMEYNEKRKLLDSELTETLSAQLELDKAAQDFRKIHLERQELIQQWENTIEQMQRRDQEIDNCALALSRIKQEAREKEGVVKEKIKFLENEVENNIEYERKISVAERKVSKCRMDYQRHEGNRSQLKDELDTLKTTLNRTSSDLQALRKNISKVKKDIFDETLRLQKLKHHNEVVKHKLKMITEKTLSIEEKATNMEDMLKEEEKGLKEVEVQLGIVKDVLFKKVQELQNEIAKEKALVSEIEGTRSSLKHLNKQLHKLDFETLKQQEIMYSQDFYIQQVERRMSRLKGEINSEEKQALEAKILELKKTMDEKKSTLSLLESQIKKLHNDLYFIKKSNGKNNDEKESLMNKISELNLFIDRSEKELSKAKAVKEDMMIEDNLLKLQVKRARELLYSKAEEVLSLEKRKQQLGKDMEERAEEIKVHKAMLTSQIRCVEQQRKTMSSEFHERLSKIDKLKNRYEILTVVMLPPEGEEEKTQSYYVIKAAQEKEELQREGDSLDAKINKAEKEIYALQNTLQVLNSCNSNYKQSFKKVTPSSDEYALKIQLEEQKRTADERYRCKQRQIRELQEDIQSMENTFEVIGHLANNAKEKLTEKQTLAFQLRKETEEQKPKLQRITKQCGRLRREIRILKQTDNETLEEQDIQLREIIQFHKDIDQMLVNAMENAEIHAIFKTYFEQNGLELPTARGPSSRSSSQSSSLSSFRSLEDVTLQSPPTAKVIQLRFPEPPPATNDSSRSASSGSNSNIPKEKKLSK

Ccdc39

Coiled-coil domain-containing protein 39

934 amino acids

Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.

Belongs to the CCDC39 family.

109.555 kDa

MSSEFLSELHWEDGFAIPVANQENKILEDQLAKLHKEKSNLQDQLRDYEDRINSMSSHLKNVNQEFLFTQSLYKARECEIESEEHFKAIAERELGRVKDEIQQLEKEMAIILERKNDKENAIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDSLTLQKYSQQDNNKIRALTLKLEKLTMECNEKRKLLDNELTETLSAQLELDKAAQDFRKIHVERQELIQQWENTIEQMQRRDQEIDNCALALARIKQEAREKEGVVREKIKFLENEVGNNVEYERRISIAERKVSKCRMEYQRQEANRNQLKDELDTLKTTLNRTSSDLEALRKNISKVKKDILDETGRLQKLKHHNEIVKHKLKMITEKTISIEEKATNMEDMLKEEEKNLKEVEVQLNIVKGVLFKKVQELQSAITKEKALGSEIEGTRSSLKHLNQRLHKLDFETLKQQEIMYSQDFYIQQVERRMSRLKGEINSEEKQALEVKIVELRKTMEERKSTLSLLEEQIKKLHNDLYFIKKSNGKNKDEKESLMNKIGELHLFVDRSEKELNKAKAVKEDLMIEDNLLKLQVKRARELLYSKAEEVLSLEKRKQQLCTAMEERVEEIKVHKAMLTSQIRYVDQQRQTVSSEFHERLSKIDKLKNRYEILTVVMLPPEGEEEKTQSYYVIKAAQEKEELQREGDSLDAKISKAEKEIYALQNTLQVLSSCNNNYKQSFKKVTPSSDEYGIKIQLEEQKRSADEKYRCKQRQIRELQEDIQSMENTFEVIEHLANNAREKLSEKQTLSFQLRKETEEQKPKIQRVTKQCGRLRREIRILRQTNDETLEEQDIQLREIIQFHKDIDQMLVNAMENAEIHVIFQTYFQQNGLELPTAKGPSSRSSSQSSLSSIRSLEDSIPISPPTAKVIELRFPGPPARSDSSRSSSGSNSNIPKGKKLNK

CCDC39

Coiled-coil domain-containing protein 39

894 amino acids

Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, by acting as a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (PubMed:25395538). Together with CCDC40/FAP172 forms a 96-nm-long complex in flagella. This complex does not act as a physical ruler, but rather act as a negative regulator for radial spokes: the complex lays along specific protofilaments, masking radial spoke binding sites and allowing recruitment of inner dynein arm (IDA) and nexin-dynein regulatory complexes (N-DRC) (PubMed:25395538).

Belongs to the CCDC39 family.

101.488 kDa

MANIDPYRTEEELVEDDEEVDMSFLPPFAKGTENEVLYVENARMERRLERTERALETNMDRLHIMDEHLKNVQQELKYTQTRVEAKNKEIESEKHLNAMAEREMGRLKKDIGKMEAERQELADKINGLQNQIYKNNEKLDQFKMLMNWNQEELEQWALAERQKAEDNAALEKYRHADDGKVKELTLALERVSKQVVGRKEELEAEVVETQAAQIQLDKAAEDFRKLHVERQDLIRQWEEAVEAMRHRDAAIAAASEQFAMQKDVLRERKRELDAQARFLENETLNTKEADARVAYYEREVGKQRDVLAREQARTEELNNQVELVKATLSKAATELAQRTVENKQAREDLDAKRQKLDAARKRFVVLKRKLENEFGNLDSMEAKASELEAMRRGEEARLKAILKEHELLKKEQYKRSQVLFDLRQKERELISEISGGQGQNKNLAARIHALDEQVVARAGGVRSEEETRALNARIEKLTAILEGVKRAEDDLLAARRANTSLRADRAKLDETISTLKLENDMVSRQVKGSVEAREKALVDHDVLALEVKRLRDILAAHADEVFSLENRKQQLALSMEERKQEVEVHRDGLRAELRLLREDVHRITLELKERLLRCEKLQAKFEIISAKHRGSGEDDGEERTQAYYVIKAAQEREALQREGDDLDGRIRVAEKEVAALEATLAQLMAVNTNFAASYKKVGSKEAFEERAALRDKLDKAYDKLKARRADEAAIAGDIQVSEARLSNLGQEQRSLQALVDDMTRRKAEAQRQLDEQREKLGRALGRTDKLRQKLGLANSPQGADVELAEVRDVTRAMLLELKALALANPGAMIAEACEAAGIRLPSGGSNPPSLGGSRPGSARSQTSLGSVRSARSVASQQRGGMGGSPAVRTIQLGA