About Products Protein Database Contact

CCDC115

Gene
ccdc115
Protein
Coiled-coil domain-containing protein 115
Organism
Danio rerio
Length
206 amino acids
Function
Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. May be involved in Golgi homeostasis.
Mass
23.775 kDa
Sequence
MRVDENLRLDEQLLLFMEQLEALEEKRQRLNSLIEEGWFSIAKARYSMGNKQVSALQYASEMQPLAHVETSLLEGGTAEFKCERSENKAEEQKTKTIEDIGAKETGLRRRVHTKQKEVKEGEQDTDEVKTKTDSPTPEHRNPLKWFGILVPQNLKQAQSAFKEVITLSVEIASLQSTILATRKEMQVQMKEKQERTEKAQLEVKEE

Gene
CCDC115
Protein
Coiled-coil domain-containing protein 115
Organism
Bos taurus
Length
180 amino acids
Function
Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (By similarity). May be involved in Golgi homeostasis (By similarity).
Mass
20.141 kDa
Sequence
MASRDLRAEVDFVLLQLLGDLEQLEAKRQALNARVEEGWLSLSKARYAMGAKSVGPLQYASHMEPQVRVGTSESQDGLQKFWMVRAGTQTPEEVGSREAALRRRKGLPRTPEPDSSPAPQNPLKWFGILVPHSLRQAQASFREGLQLAADMASLQSRITWGQSQLQELQEKLKQLEPRAP

Gene
CCDC115
Protein
Coiled-coil domain-containing protein 115
Organism
Homo sapiens
Length
180 amino acids
Function
Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633). May be involved in Golgi homeostasis (PubMed:26833332).
Mass
19.761 kDa
Sequence
MAALDLRAELDSLVLQLLGDLEELEGKRTVLNARVEEGWLSLAKARYAMGAKSVGPLQYASHMEPQVCLHASEAQEGLQKFKVVRAGVHAPEEVGPREAGLRRRKGPTKTPEPESSEAPQDPLNWFGILVPHSLRQAQASFRDGLQLAADIASLQNRIDWGRSQLRGLQEKLKQLEPGAA

Gene
Ccdc115
Protein
Coiled-coil domain-containing protein 115
Organism
Mus musculus
Length
180 amino acids
Function
Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (By similarity). May be involved in Golgi homeostasis (By similarity).
Mass
19.743 kDa
Sequence
MAVQALREELDSKCLQLLSDLEELEAKRAALNARVEEGWLSLAKARYAMGAKSVGPLQYASRMEPQVCVRASEAQDGPQTFRVIKADAQTPEEVGPSEASLRRRKGPTKTKELGSAVVPQDPLNWFGILVPHSLRQAQASFRDGLQLAADIASLQTRINWGQSQLRGLQKKLKELDPGPA