Protein
Adenylate-forming reductase 03009
Organism
Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
Function
Adenylate-forming reductase, a natural product biosynthesis enzyme that resembles non-ribosomal peptide synthetases, yet serves to modify one substrate, rather than to condense two or more building blocks. The A-domain preferentially accepts L-serine, L-alanine and L-valine as substrates. The natural product of the enzyme is not yet known.
Similarity
Belongs to the adenylate-forming reductase family.
Sequence
MASSDLLSHLSATDRALFWKYGVGAEVSVPFQCVHHAFEFHAKSNPQLTAVDELGTTLSYGELDRRANCLASRLRSVGVVQGSRVCMLVERAVTLPVAVLGILKAGAAYIPLDGNIVSDSTLKHALVDSGSTVALTLRKFEHRLEGAPVPVVFLDDAICPSYNPSHCVKPRDTTTSKDSVYIIYTSGTTGTPKGVHVTHGNVTNLICIEPGQLGMKPGVRVSQMLNISFDFAAWEILGSLANGATLCPRGKTSKDWKAVMRSVDILFSTPSMLAPHNPVDYPNVKTVVVAGEACPKALADTWGARVKFWNACGPTEVTIANTMQLHIPGDIVTIGGPTPNNTAYVLDENMRPVPIGQTGVMWGGGAGITKGYLNLPDKTSERYVRDPFANDGSMMFNTGDLGKWVSNGTLQHLGRIDNQVKIKGFRVELDGVATAMETCAGVTGATALLIDGELWGFVKPSNISPEDIKAAAHKVQPYYAVPSKILTMDHFPETANGKTDKRVLQQMAIESKEEEAKLKEEKAAIPENVAWISLPPTVVTAPKTELTIPHRPSDHSLGSTNTKISAQVKEADSSASSTSELEKQEYIWSGYQDDDHPEKTQGRLVRNLRHQIFSLYRRLFSVVFIVNAAILIWICVKKEYDANRIGGIVIANVFIGVLMRQELVINTFFLIFTSIPSSWPLFIRRTAARVYHIGGIHSGAGVSSLLWLCLFTAQATKEMINGGKTSVRTVAITYVILAELLGIVIFAYPALRKRLHDTFENTHRFLGWSALALVWVQFMFLTIDYLPEGQMLGQTLVKTPQFWLVIILTCSVIWPWFRLRKVDVKPEVLSNHAVRLWFDYVTPPAGTFMRVSDAPLKEWHGFAAIPIPGRTGYSLVVSRAGDWTSKHIANPPTKLWVKGVPTYGVLKLVPMFRRMVIVATGSGIGPCAPAIFEKRIPMRVLWTAPNVRETFGDKLVDSILEANPEAVIYDTRKHGKPDMVKLTLRLVKEFNAEAVAIISNQPLTEKVVYGMMSRGIPAFGAIWDS