Protein
U1 small nuclear ribonucleoprotein C
Organism
Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
Function
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Similarity
Belongs to the U1 small nuclear ribonucleoprotein C family.
Sequence
MPKHYCDYCDVFLTHDSASVRKAHNSGRNHLANVRDYYASLGHDKAQSIIDQITSAFESGQGPPPGGFGFGPQHLQAPPQGGFAPPMGGFPPGGFPPGPRPPFPPGPGFPPMMPPGAPPFPPNAMPPPGAFGGPPPFPPNGPPGAPPFPPNASQQGGPPGAPSFPPPPGGFNGPPPPSGQNSQGPPPPTNPGPGGMHPDRARMMGPGGR