cbll1

E3 ubiquitin-protein ligase Hakai

496 amino acids

E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing.

Belongs to the Hakai family.

55.539 kDa

MDHNDNDLQGTNSMGSLSGLDVRRRIPIKLISKHPNKIKPAPRPQRNMNRIPTKPQPGFDYNEEERYENKGDVFNNQRRFSAHLFWDFKLNLIGEKEDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCALMHEKKADKLCPGTLVEDSTDTFKRMSCNDPVQRIEQCARGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRASKPTARPQPEPIHPPLAPPPAEIPDRFIMPPDKHHLSHMPPKQHILMPPPPMQHVPHEHFSQQHDDIRPSPADISLAPPPPRSVNQDAFRISTRQHSNLITVPIQDDSNSGARETPQAPGPTLHHPEYPGQPVVAHPHHIMPPQQHYAPPPPPPPPISHPMQHPPQAAGTPHMVYSQGPPPPMTTAPPPITPPPGHIIAQIPPYMNHPPPGPPPQHGGPPVNAPPPHHYNPSSMPQFNEDQGTLSPPFTQPGGMSPGMWPAPRGPPPRMQGPPSQAPMPGPHHPDQARYRPYYQ

CBLL1

E3 ubiquitin-protein ligase Hakai

493 amino acids

E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing.

Belongs to the Hakai family.

54.851 kDa

MDHNDNDLQGTNSSASLGGLDVRRRIPIKLISKQTNKTKPAPRAPRAMNRMPAKTQAGDEEEFDFNEEERYECKGGEMFGNQRRFPGPIFWDYKINLLGEKDDTPVHFCDKCGLPIKMYGRMIPCKHVFCYDCAILHEKKGDKMCPGCNEPVQRIEQCVRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRPPLEPVHPPIAPPPAEIPERFIMPPEKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRPPPAEMSMAPPPPRPVSQDTFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVTHPHHIMPPQQHYAPPPPPPPPISHPLQHPPQAAGTPHMVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVNVSAPPPHHYNPNSLPQFSEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRMQGPPAQAPLAGPHHPDQARYRPYYQ

Cbll1

E3 ubiquitin-protein ligase Hakai

491 amino acids

E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (PubMed:11836526, PubMed:22252131). Targets CDH1 for endocytosis and degradation (PubMed:11836526). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189, PubMed:29547716). Its function in the WMM complex is unknown (PubMed:29535189, PubMed:29547716).

Belongs to the Hakai family.

54.444 kDa

MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQASKVKPAPRTQRTVSRMPAKAPQGDEEGFDYNEEQRYDCKGGELFGNQRRFPGHLFWDFKINILGEKDDTPVHFCDKCGLPIKVYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTDIPDRFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDDSSSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRMQGPPSQTPLPGPHHPDQTRYRPYYQ

CBLL1

E3 ubiquitin-protein ligase Hakai

491 amino acids

E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755).

Belongs to the Hakai family.

54.519 kDa

MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDEEGFDYNEEERYDCKGGELFANQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTEIPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ

CBLL1

E3 ubiquitin-protein ligase Hakai

490 amino acids

E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown.

Belongs to the Hakai family.

54.376 kDa

MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDEGFDYNEEERYDCKGGELFGNQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTEIPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ