Protein
Phosphatidate cytidylyltransferase, mitochondrial
Organism
Caenorhabditis briggsae
Function
Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane.
Similarity
Belongs to the TAM41 family.
Sequence
MDEYRELISVLPLDTVEYAFAYGSGAIQQKDENKAEKMVDFVVVTKDAQEFHKANIAKNPQHYSLLRLLGPKMLEKIQCNFAARVYYNTHVNVGKRKIKYGIISYENVKQDLLDWRWIYISGRLHKPVLDVIKPKDDMCDLVTENRRSALHSALLLLPESFTLKQLFHQIVGLSYTGDFRMIVGEDKNKIMKIVEGNYEELMRVYEPLMNDDARLSVMSPAKVIQDGSTTAIYHRLNLLPSEVLNQIQKNMNKAQKRQRDAEEVIFSLAHRHDVAATVETAIGGIIRPISFSQTAKNAFSAGMTRSVIYSLAKMSKFLKSK