Protein
CCR4-NOT transcriptional complex subunit CAF120
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Function
Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
Similarity
Belongs to the CAF120 family.
Sequence
MRIFSGDNKVVDSLASNPGLMSPSNFGGDFGSRLKVNVTSKKKLNDSSPTSPMESSPVSPELVPILTLLNAHTHRRYHEGVFLILQDLNNNGTHAARKWKDVYGVLLGTQLALWDAKELAEFTDPSCPVSEKKLKEVASKPTYINLTDATLRTLDNSDNIVMECGKNLTNALVVSTTLKNRYFLQFGNKESFNAWNSAIRLCLYECSSLQEAYTGAFISSRGAKLGDIRILLTNRKYDYKDWVSVRFGAGMPWKRCYAVISQSSSKKKGHFGEINLYENDKKVKKNHAMATIVEAKALYAVYPSSPKLIDSSTIIKVVGSVKFEKKESAQEKDVFIMPEKHQAVPSYDTIIRFLIPAMDTFKLYGRPEKLLSSKNDPHSLLFGLPVLPHIYYLEVEDLLPLTNSVSSLHWSNNEWKEHISDILQRKIAQGYCGCNSTSNITSPLPSPFLGSADLFERADGVLSPKLSYGSKSSSNNSSKNSLPKRERVKLSSSSEQDLNNSDSPSIKRKSPPLVISESPHKVHTPTDASFRTRVTEGSPYAKQRHPKPFASSVNDSPSDRAKSRTVPYNNNDRKATTPEKFERGETSCGKNVDESLEKVRNMKLEIPESNFDKFMTDKNLLSVDSKCSNEKKLSVESDLSAIYEKYSNGPFGHTEGLNGSSDETYLRFQRASVHSESNYNSRKSFTPSDFSNGNEEEHAVLQELNSLTQRINELGMESINSNSDSDRINGSYSQVDFGNNNDEDDMNLFDPDFMAQDQLRAEERDYNKDDRTPLAKVPAAFQSTGLGITPDDDIERQYITEHRSRHEVPKRSPEKPSNPLEIGNPYAKPGTRLNTTHTHSKTDRSITPQRGQPVPSGQQISSYVQPANINSPNKMYGANNSAMGSPRNPKTRAPPGPYNQGWNNRPSPSNIYQRPHPSDTQPQAYHLPGNPYSTGNRPNMQAQYHPQQVPMPILQQPNRPYQPYAMNTHMGSPGGYAGAAPPFQPANVNYNTRPQQPWPTPNSPSAHYRPPPNLNQPQNGSAGYYRPPAPQLQNSQARPQKKDGFSQFMPSATTKNPYAQ