Protein
Diphthamide biosynthesis protein 2-2
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Function
Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.
Similarity
Belongs to the DPH1/DPH2 family. DPH2 subfamily.
Sequence
MTSETVIAPSLSTAQNDGTFTYDKVKSTAKERKHLNLKNPSDANEIKSKIWNYYSLSELIQYLGQKENDDFKYKRITLQFPDNLICDSATIVHELQRELNIVPQANQDTGESNTAQRVWILADTSYSACCVDEVAAEHVRSDLVVHFGDACLNEIDKLQAVFVLGKPTLDVDAIVKQIKTAYSTEQKVVLMSDAPHTYLLPEIAKQLPDYDILIADLPKTSRAKIIGYTPPPTGHKKFNRVFNTDTVEFGKYELFHITSPESPRLLQLTTNFASVTTYDPISGTVSTGPFPNLMRRYKYVHQARMAGTVGILVNTLSLANTKVLLNTIKEKIKEAGKKHYIFVVGKPNVAKLANFESVDIWCILGCDHQGIIIDQINEYYKPIVTPYELLLGLSDELSWTGKWVVDYKSVLEEYGNEVIQQNEDPDTDEDLPPVFDPVTGRYVSTSKPLRQINHLMVTSSEQGGVDDHDNQLVKRFSNAVAIKGTVSTSAIHLQNRHWTGLGSDYTEDENAAGALVEDGRKGIARGYDI