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Brca2

Gene
BRCA2
Protein
Breast cancer type 2 susceptibility protein
Organism
Homo sapiens
Length
3418 amino acids
Function
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180).
Mass
384.202 kDa
Sequence
MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPNLFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTVKTKMDQADDVSCPLLNSCLSESPVVLQCTHVTPQRDKSVVCGSLFHTPKFVKGRQTPKHISESLGAEVDPDMSWSSSLATPPTLSSTVLIVRNEEASETVFPHDTTANVKSYFSNHDESLKKNDRFIASVTDSENTNQREAASHGFGKTSGNSFKVNSCKDHIGKSMPNVLEDEVYETVVDTSEEDSFSLCFSKCRTKNLQKVRTSKTRKKIFHEANADECEKSKNQVKEKYSFVSEVEPNDTDPLDSNVANQKPFESGSDKISKEVVPSLACEWSQLTLSGLNGAQMEKIPLLHISSCDQNISEKDLLDTENKRKKDFLTSENSLPRISSLPKSEKPLNEETVVNKRDEEQHLESHTDCILAVKQAISGTSPVASSFQGIKKSIFRIRESPKETFNASFSGHMTDPNFKKETEASESGLEIHTVCSQKEDSLCPNLIDNGSWPATTTQNSVALKNAGLISTLKKKTNKFIYAIHDETSYKGKKIPKDQKSELINCSAQFEANAFEAPLTFANADSGLLHSSVKRSCSQNDSEEPTLSLTSSFGTILRKCSRNETCSNNTVISQDLDYKEAKCNKEKLQLFITPEADSLSCLQEGQCENDPKSKKVSDIKEEVLAAACHPVQHSKVEYSDTDFQSQKSLLYDHENASTLILTPTSKDVLSNLVMISRGKESYKMSDKLKGNNYESDVELTKNIPMEKNQDVCALNENYKNVELLPPEKYMRVASPSRKVQFNQNTNLRVIQKNQEETTSISKITVNPDSEELFSDNENNFVFQVANERNNLALGNTKELHETDLTCVNEPIFKNSTMVLYGDTGDKQATQVSIKKDLVYVLAEENKNSVKQHIKMTLGQDLKSDISLNIDKIPEKNNDYMNKWAGLLGPISNHSFGGSFRTASNKEIKLSEHNIKKSKMFFKDIEEQYPTSLACVEIVNTLALDNQKKLSKPQSINTVSAHLQSSVVVSDCKNSHITPQMLFSKQDFNSNHNLTPSQKAEITELSTILEESGSQFEFTQFRKPSYILQKSTFEVPENQMTILKTTSEECRDADLHVIMNAPSIGQVDSSKQFEGTVEIKRKFAGLLKNDCNKSASGYLTDENEVGFRGFYSAHGTKLNVSTEALQKAVKLFSDIENISEETSAEVHPISLSSSKCHDSVVSMFKIENHNDKTVSEKNNKCQLILQNNIEMTTGTFVEEITENYKRNTENEDNKYTAASRNSHNLEFDGSDSSKNDTVCIHKDETDLLFTDQHNICLKLSGQFMKEGNTQIKEDLSDLTFLEVAKAQEACHGNTSNKEQLTATKTEQNIKDFETSDTFFQTASGKNISVAKESFNKIVNFFDQKPEELHNFSLNSELHSDIRKNKMDILSYEETDIVKHKILKESVPVGTGNQLVTFQGQPERDEKIKEPTLLGFHTASGKKVKIAKESLDKVKNLFDEKEQGTSEITSFSHQWAKTLKYREACKDLELACETIEITAAPKCKEMQNSLNNDKNLVSIETVVPPKLLSDNLCRQTENLKTSKSIFLKVKVHENVEKETAKSPATCYTNQSPYSVIENSALAFYTSCSRKTSVSQTSLLEAKKWLREGIFDGQPERINTADYVGNYLYENNSNSTIAENDKNHLSEKQDTYLSNSSMSNSYSYHSDEVYNDSGYLSKNKLDSGIEPVLKNVEDQKNTSFSKVISNVKDANAYPQTVNEDICVEELVTSSSPCKNKNAAIKLSISNSNNFEVGPPAFRIASGKIVCVSHETIKKVKDIFTDSFSKVIKENNENKSKICQTKIMAGCYEALDDSEDILHNSLDNDECSTHSHKVFADIQSEEILQHNQNMSGLEKVSKISPCDVSLETSDICKCSIGKLHKSVSSANTCGIFSTASGKSVQVSDASLQNARQVFSEIEDSTKQVFSKVLFKSNEHSDQLTREENTAIRTPEHLISQKGFSYNVVNSSAFSGFSTASGKQVSILESSLHKVKGVLEEFDLIRTEHSLHYSPTSRQNVSKILPRVDKRNPEHCVNSEMEKTCSKEFKLSNNLNVEGGSSENNHSIKVSPYLSQFQQDKQQLVLGTKVSLVENIHVLGKEQASPKNVKMEIGKTETFSDVPVKTNIEVCSTYSKDSENYFETEAVEIAKAFMEDDELTDSKLPSHATHSLFTCPENEEMVLSNSRIGKRRGEPLILVGEPSIKRNLLNEFDRIIENQEKSLKASKSTPDGTIKDRRLFMHHVSLEPITCVPFRTTKERQEIQNPNFTAPGQEFLSKSHLYEHLTLEKSSSNLAVSGHPFYQVSATRNEKMRHLITTGRPTKVFVPPFKTKSHFHRVEQCVRNINLEENRQKQNIDGHGSDDSKNKINDNEIHQFNKNNSNQAAAVTFTKCEEEPLDLITSLQNARDIQDMRIKKKQRQRVFPQPGSLYLAKTSTLPRISLKAAVGGQVPSACSHKQLYTYGVSKHCIKINSKNAESFQFHTEDYFGKESLWTGKGIQLADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISRIWVYNHYRWIIWKLAAMECAFPKEFANRCLSPERVLLQLKYRYDTEIDRSRRSAIKKIMERDDTAAKTLVLCVSDIISLSANISETSSNKTSSADTQKVAIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQKIILHGAELVGSPDACTPLEAPESLMLKISANSTRPARWYTKLGFFPDPRPFPLPLSSLFSDGGNVGCVDVIIQRAYPIQWMEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENTTKPYLPSRALTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDKKQAQIQLEIRKAMESAEQKEQGLSRDVTTVWKLRIVSYSKKEKDSVILSIWRPSSDLYSLLTEGKRYRIYHLATSKSKSKSERANIQLAATKKTQYQQLPVSDEILFQIYQPREPLHFSKFLDPDFQPSCSEVDLIGFVVSVVKKTGLAPFVYLSDECYNLLAIKFWIDLNEDIIKPHMLIAASNLQWRPESKSGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDILCNEAENKLMHILHANDPKWSTPTKDCTSGPYTAQIIPGTGNKLLMSSPNCEIYYQSPLSLCMAKRKSVSTPVSAQMTSKSCKGEKEIDDQKNCKKRRALDFLSRLPLPPPVSPICTFVSPAAQKAFQPPRSCGTKYETPIKKKELNSPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEKQFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI

Gene
BRCA2
Protein
Breast cancer type 2 susceptibility protein homolog
Organism
Felis catus
Length
3372 amino acids
Function
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability, independently of its known role in homologous recombination (By similarity).
Mass
377.345 kDa
Sequence
MPIGCKERPTFFEIFRTRCNKADLGPISLNWFEELCLEAPPYNSEPTEESGYKISYEPNLFKTPQRKPCHQLASTPIIFKEQGLIPPIYQQSPLKELGKDITNSKHRSCCTMKSKMDQTNDVTSPPLNSCLSESPLLRSTHVTPQREKSVVCGSLFHTPKLTKGQTPKRISESLGAEVDPDMSWSSSLATPPTLSSTVLIVRDEEASAAVFPNDTTAIFKSYFCNHDESLKKNDRFIPSGPDSENKSQREAKSQGLGKMVGNSCDKVNSCKDPFGNSTLNVLEDGVRERVADVSEEDSFPLCVPKCKTRNLQKIKTSKTRKNIFNETTDECKEAKKQMKENKHSFVSEMEANASDPLDSNVTNQKPFGNGSDKISKEVVLSSASESCHLTLSGLNGTHMEKLPLLCISSCDQNNSEKDLITTEKECTNFIILEDSLPQISGVPKCTEKILNEEIVVNKIDEGQCLESHEDSILAVKQAVFETSLIASPLQGIRKSIFRIRESPEETFSAVFSNNITDPNFKEEHEASESVLEKHSICSQKEDSLSTSSLDNGSWPATIKHTSVALKNSGLISTLKKKTKKFIYVVNDETSYQGLKTQKDQQSGLMNYSAQFEANVLEGPLTFANADSGLLHSSVKKTCLQNDSKEPILSLTNSFGTLLRKVSNKGSSSPNNKIISQDLDYKEAKIKKEKLQSFISTETNCLSSLQEKHCEDDTKSQRVADRKEEILPAVSQPSVPYSEVEDSGIHFQTLKSFSSDPDKSSQLTPHPRDPPSNPVGLSRGRESYEVSETLKCKNHEAGFELTKTMENSQEIHVLNEHAKKAKLLSTEKYVTEASPSMKVPFNQNAHLTIIQKDQKETTLISKITMNPNSEELFPDGDNFVFKITKERNVPVLGSIKELQDSDLCCVKEPVLENSTMVVYTDMDDKQAAKVSITKGFDSSNIDDLTEKDRNSIKQQLRMTLDQDSKSDITLDSDMKSNGNNDYMDNWARLSDPILNHNFGNGFRTASNKEIKLSEHNIKKSKMLFKDIEERYPTNLACIEIVNTPLESQEKLSKPHILDPQSINTVSGCVQSSAYVSDSENRHTTPPTLSLKRDFDSNHNLTPSQKAEITELSTILEESGSQFEFTQFRKPSHLKQKNPCEMPEKHLTISNTTPEEQKDGHLRLTINALSISQGDSSKKFEGIIGGKQKLACLSKTSCNKSASGHLTGKNEVEFRGFYSARGTKLNVCSEALQKAKKLFSDLENISEETSVEVDRSFSSSKCNGSVSMFKKENCNNEKKLNEKNNKYRLILQNNIEMTTGIFVAEDTEGYKRNIENKANKYTDASRNVYNFREADGSDSSKNDTVYIHKEENGLPYIDQHDIDLKLSSQFIKEGNTQIKEGLSDLTCLEVVKAEETLHVNTSNKEHLTANTMGRITKDFDIFDVSFQTASGKNIRVSRASLNKVTNLLDQKCTEEELNNFADSLNSELLSGIDINKADISHHGEMEILKKRQMKESDLTGTENKSLTLQQRPEYEIKKIKEPTILGFHTASGKRIEIAKESLDKVKNLFDEQEQDKSEMTNFSHRGTKMSKGREECEGGLRLACKTIEITPASKEEEMQKPLEKNLVSNEIVVVPRLLSDNLYKQTENLKIPNRASLKVKVHENTGKETAKKPTTCTNQSTYSATENSALSFYTGHGRKISVSQSSILEVKKWLRGGELDDQPEKTVYNISEYLPKSKVDNSGIEPVVRNVGERENTSVSEIMFTVREADTDPQSVNEDICVQRLVTNFSCKKENTAIKVTVSDSNNFDSTQKLNSDSNDAVPVYTTASSERVLVAHETKVAEGFTENCSMAIKQTTKSKPGKIVAGYRKAPDDSEDTICPNSLDGAECSSPSHKDFAETQSEQTPQLNQSISGFKKRSEIPPHQINLKTSDICKLSTGKRLQSISYTNACGIFSTASGKCVQVSDAALQKARQVFSKVEDSAKQPFSKVSFKHNEDHSDKFTREENTMIHTPQNLLSSAFSGFSTASGKQVPVSESALCKVKGILEEFDVMRTECGPQRSPTSRQDVSKMPPPSCVENKTPKHSVNSKLEKAYNKEFKLSSNSKIENGSSENHSVQVSPYPSQFKQDKQLIQGNKASLVENIHLLEKEQALPKNIKWKLETEAFPNLPLKTDTAIHSTDSKDPENYFETETVEIAKAFMEDGELTDADLLSHARHFLPTCQHSEETLVSNSRRGKRRGVLVSVGEPPIKRNLLNEFDRIIKNQEKSLKASKSTPDGIIKDRSLFMHHISLEPVTCGPFSTTKKRQEIQNPNFTAPGQKFLSKSHFYEHLALEKSSSNVSISGQPFCTVPATRSEKRGHSITPSKPVKVFVPPFKTKSRFLQDEQHISKNTHVEENKQKPNNIDEHSSGDSKNNINNSEIHQLNKNNSSQAATMVFTKCEKEPLDLIASLQNARDIQDMRIREKRKQHIFPQPGSLFLAKTSTVPRISLRVAVEGRVPSACSHKQLYMYGVSKHCVKINSKNAESFQFHTQDYFGKEVQWAKEGIQLADGGWLIPSNDGKAGKEEFYRALCDTPGVDPNLISRIWVYNHYRWIIWKLAAMEFAFPKEFANRCLSPERVLLQLKYRYDMEIDRSKRSAIKKIMERDDTAAKTLVLCISETISSSTDLSETSGSKTSGVGTKNVGIVELTDGWYAIKAQLDPPLLALVKKGRLTVGHKIIIHGAELAGSPDACTPLEAPESLILKISANSTRPACWYAKLGFFPDPRPFPLPLSSLFSDGGNVGCVDVVIQRTYPIQWMEKTPSGLCIFRNEREEEREATKYAEAQQKKLEVLFNKIQAEFEKHDENITKRCVPLRALTRQQVCALQDGAELYEAVKNAPDPASLEAYFSEEQIRALNNHRQMLNDKKQAQIQLEFRKAMESAEQGEQMLPRDVTTVWKMRIISYGKKEKDSVTLSIWRPSSDLYSLLTEGKRYRIYHLATSQSKSKSERAHIQLTATKKTQYQQLPASDELLFQVYQPREPLYFNKLLDPDFQPPCSEVDLIGFVVSVVKKIGFAPLVYLSDECHNLLAIKVWTDLNEDIVKPHTLIAASNLQWRPESKSGIPTLFAGDFSRFSASPKEGHFQETFHKMKNTIENVETFCNDAENKLVHILNANSPKVSTPMKDYASEPHTIQTVLGLGNKLSMSSPNSEMNYQSPLSLCKPKAKSVPTPGSAQMTSKSCYKGERELDDPKTCKKRKALDFLSRLPLPPPVSPICTFVSPAAQKAFQPPRSCGTKYETPIKKRELNSPQMTPLKFNDTSLVESDSIADEELALINTQALLSGLAGEDQLMSLNDSPRTAPTSSKDYVRPKSYPTAPGIRDCENPQASTEGGEPDVQDTDTVKRSSMRLQRRQQQT

Gene
Brca2
Protein
Breast cancer type 2 susceptibility protein homolog
Organism
Rattus norvegicus
Length
3343 amino acids
Function
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability, independently of its known role in homologous recombination (By similarity).
Mass
372.216 kDa
Sequence
MTVEYKRRPTFWEIFKARCSTADLGPISLNWFEELFSEAPPYNTEHPEESEYKPQGHEPQLFKTPQRNPSYHQFASTPIMFKEQSQTLPLDQSPFKELGNVVANSKRKHHSKKKARKDPVVDVASLPLKACPSESPCTPRCTQVAPQRRKPVVSGSLFYTPKLEETPKHISESLGVEVDPDMSWTSSLATPPTLSSTVLIARDEEAHRNAFPADSPASLKSYFSNHNESLKKNDRFIPSVSDSENKSQQEAFSQGLEKMLGDSSSKINRFRDCLRKPIPNVLEDGETAVDTSGEDSFSLCFPKRRTRNLQKTRMGKMKKKIFSETRTDGLSEEARGQADDKNSFALEIEPRDSEPLDPSVTNQKPLYSQSGDISSEAGQCSDSIWSQPDPSGLNGTQTRKIPLLHISFHKQSILEDFIDMKKEGTGSITFPHISSLPEPEKMFSEETLVDKEHEGQHLESLEDSISGKQMVSGTSQTACLSPSIRKSIVKMREPLEETLDTVFSDSMTSSAFTEELDASAGGLEIHTACSQREDSLCPSSVDTGSWPTTLTDTSATVKNAGLITTLKNKRRKFIYSVSDDASHQGKKLQTQRQSELTNLSAPFEASAFEVPFPFTNVDSGIPDSSIKRSNLPNDPEEPSLSLTNSFVTAASKEISYIHALISQDLNDKEAILSEEKPQPYTALEADFLSCLPERSCENDQKSPKVSDRKEKVLVSACRPSGRLAAAVQLSSISFDSQENPLGSHNVTSTLKLTPSPKTPLSKPVVVSRGKMCKMPEKLQCKSCKDNIELSKNIPLGVNEMCVLSENSETPELLPPLEYITEVSSSVKSQFNQNTKIAVVQKDQKDSTFISEVTVHMNSEELFPEKENNFAFQVTNESNKPNIGSTVEFQEEDLSHAKGHSLKNSPMTVDRDLDDEQAGQVLITEDSDSLAVVHDCTKKSRNTIEQHQKGTADKDFKSNSSLYLKSDGNNDYLDKWSEFLDPLMNHKLGGSFRTASNKEIKLSEDNVKKSKMFFKDIEEQYPTSLDCIDTVSTLQLANKKRLSEPHTFDLKSGTTVSTQCHSQSSVSHEDTHTAPQMLSSKQDFHSSHNLTPSQKAEITELSTILEESGSQFEFTQFKNPSHIAQNNTSAVLGNQMAVVRTASEEWKDVDLHLPLNPSSVGQIDHNKKFECLVGVKQSSSHLLEDTCNQNTSCFLPIKEMEFGGFCSALGTKLSVSNEALRKAMKLFSDIENISEEPSTKVGPRGFSSCAHHDSVASVFKIKKQNTDKSFDEKSSKCQVTVQNNKEMTTCILVDENPENYVKNIKQDNNYTGSQRNAYKLENSDVSKSSTSGTVYINKGDSDLPFAAEKGNKYPESCTQYVREENAQIKESVSDLTCLEVMKAEETCHMKSSDKEQLPSDKMEQNMKEFNISFQTASGKNIRVSKESLNKSVNILDQETEDLTVTSDSLNSKILCGINKDKMHISCHKKSINIKKVFEEHFPIGTVSQLPALQQYPEYEIESIKEPTLLSFHTASGKKVKIMQESLDKVKNLFDETQYVRKTTNFGHQESKPLKDREDYKERLTLAYEKIEVTASKCEEMQNFVSKQTEMLPQQNDHMYRQTENLTSNGSSPKVHGNIENKIEKNPRICCICQSSYFVTEDSALACYTGDSRKTCVGESSLSKGKKWLREQSDKLGTRNTIEIQCVKEHTEDFAGNALYEHSLVIIRTEIDTSHVSENQASTLFSDPNVCHSYLSHSSFCHHDDMHNDSGYFLKDKIDSDVQPDMKNTEGNAIFPKISATKEIKLHPQTVNEECVQKLETNASPYANKNIAIDSAMLDLRNCKVGSPVFITTHSQETVRMKEIFTDNCSKIVEQNRESKPDTCQTSCHKALDNSEDFICPSSSGDVCINSPMAIFYPQSEQILQHNQSVSGLKKAATPPVSLETWDTCKSIRGSPQEVHPSRTYGFFSTASGKAVQVSDASLEKARQVFSEIDGDAKQLASMVSLEGNEKSHHSVKRESSVVHNTHGVLSLRKTLPGNVSSFVFSGFSTAGGKLVTVSESALHKVKGMLEEFDLIRTEHTLQHSPTPEDVSKIPPQPCLESRTPEYSVSSKLQKTYNDKSRSPSNYKESGSSGNTQSLEVSPQLSQMERKQETQSVLGTKVSQRKTNILEKKQNLPQNIKIESNKMETFSDVSMKTNVGEYYSKEPENYFETEAVEIAKAFMEDDELTDSEQTHAKCSLFACPQNEALLNSRTRKRGGMAGVAVGQPPIKRSLLNEFDRIIESKGKSLTPSKSTPDGTIKDRRLFTHHMSLEPVTCGPFCSSKERQETQSPHVTSPAQGLQSKEHPSRHSAVGKSSSNPTVSALRSERTRHSVSDKSTKVFVPPFKVKSRFHRDEHFDSKNVNLEGKNQKSADGVSEDGNDSDFPQFNKDLMSSLQNARDLQDIRIKNKERHHLCPQPGSLYLTKSSTLPRISLQAAVGDSVPSACSPKQLYMYGVSKACISVNSKNAEYFQFAIEDHFGKEALCAGKGFRLADGGWLIPSDDGKAGKEEFYRALCDTPGVDPKLISSVWVSNHYRWIVWKLAAMEFAFPKEFANRCLNPERVLLQLKYRYDVEIDNSSRSALKKILERDDTAAKTLVLCVSDIISLSTNVSETSGSKASSEDSNKVDTIELTDGWYAVKAQLDPPLLALVKSGRLTVGQKIITQGAELVGSPDACAPLEAPDSLRLKISANSTRPARWHSKLGFFHDPRPFPLPLSSLFSDGGNVGCVDVIVQRVYPLQWVEKTVSGSYIFRNEREEEKEALRFAEAQQKKLEALFTKVHTELKEHEEDIAQRRVLSRALTRQQVHALQDGAELYAAVQDASDPEHLETCFSEEQLRALNNYRQMLSDKKQARIQSEFRKALEAAEKEEGLSRDVSTVWKLRVTSYKKREKSALLSIWRPSSDLPSLLTEGQRYRIYHLSVSKSKNKFEWPSIQLTATKRTQYQQLPVSSETLLQLYQPRELLPFSKLSDPAFQPPCSEVDVVGVVVSVVKPIGLAPLVYLSDECLHLLVVKFGIDLNEDIKPRVLIAASNLQWRPESTSRVPTLFAGNFSVFSASPKEAHFQERVTNMKHAIENIDTFYKEAEKKLIQVLKGDSPKWSTPNKDPTREPYPASTCSASDLASGGQLPRSSPTDQQSYRSPLSCCTPTGKSTPLAHSAWMAAKSCSGENEIEDPKTCRKKRALDLLSRLPLPPPLSPVCTFVSPAAQKAFQPPRSCGTKYPTPLKKEGPSSPWSRAPFQKASGVSLLDCDSVADEELALLSTQALVPHSVGGSEQVFPSDSTRTEGPSASTEARPANRSKRESLRDCRDDSDGKLAAETVPDYS

Gene
Brca2
Protein
Breast cancer type 2 susceptibility protein homolog
Organism
Mus musculus
Length
3329 amino acids
Function
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability, independently of its known role in homologous recombination (By similarity).
Mass
370.664 kDa
Sequence
MPVEYKRRPTFWEIFKARCSTADLGPISLNWFEELSSEAPPYNSEPPEESEYKPHGYEPQLFKTPQRNPPYHQFASTPIMFKERSQTLPLDQSPFRELGKVVASSKHKTHSKKKTKVDPVVDVASPPLKSCLSESPLTLRCTQAVLQREKPVVSGSLFYTPKLKEGQTPKPISESLGVEVDPDMSWTSSLATPPTLSSTVLIARDEEARSSVTPADSPATLKSCFSNHNESPQKNDRSVPSVIDSENKNQQEAFSQGLGKMLGDSSGKRNSFKDCLRKPIPNILEDGETAVDTSEEDSFSLCFPKRRTRNLQKMRMGKTRKKIFSETRTDELSEEARRQTDDKNSFVFEMELRESDPLDPGVTSQKPFYSQNEEICNEAVQCSDSRWSQSNLSGLNETQTGKITLPHISSHSQNISEDFIDMKKEGTGSITSEKSLPHISSLPEPEKMFSEETVVDKEHEGQHFESLEDSIAGKQMVSRTSQAACLSPSIRKSIFKMREPLDETLGTVFSDSMTNSTFTEEHEASACGLGILTACSQREDSICPSSVDTGSWPTTLTDTSATVKNAGLISTLKNKKRKFIYSVSDDASLQGKKLQTHRQLELTNLSAQLEASAFEVPLTFTNVNSGIPDSSDKKRCLPNDPEEPSLTNSFGTATSKEISYIHALISQDLNDKEAIVIEEKPQPYTAREADFLLCLPERTCENDQKSPKVSNGKEKVLVSACLPSAVQLSSISFESQENPLGDHNGTSTLKLTPSSKLPLSKADMVSREKMCKMPEKLQCESCKVNIELSKNILEVNEICILSENSKTPGLLPPGENIIEVASSMKSQFNQNAKIVIQKDQKGSPFISEVAVNMNSEELFPDSGNNFAFQVTNKCNKPDLGSSVELQEEDLSHTQGPSLKNSPMAVDEDVDDAHAAQVLITKDSDSLAVVHDYTEKSRNNIEQHQKGTEDKDFKSNSSLNMKSDGNSDCSDKWSEFLDPVLNHNFGGSFRTASNKEIKLSEHNVKKSKMFFKDIEEQYPTRLACIDIVNTLPLANQKKLSEPHIFDLKSVTTVSTQSHNQSSVSHEDTDTAPQMLSSKQDFHSNNLTTSQKAEITELSTILEESGSQFEFTQFRKPSHIAQNTSEVPGNQMVVLSTASKEWKDTDLHLPVDPSVGQTDHSKQFEGSAGVKQSFPHLLEDTCNKNTSCFLPNINEMEFGGFCSALGTKLSVSNEALRKAMKLFSDIENSEEPSAKVGPRGFSSSAHHDSVASVFKIKKQNTEKSFDEKSSKCQVTLQNNIEMTTCIFVGRNPEKYIKNTKHEDSYTSSQRNNLENSDGSMSSTSGPVYIHKGDSDLPADQGSKCPESCTQYAREENTQIKENISDLTCLEIMKAEETCMKSSDKKQLPSDKMEQNIKEFNISFQTASGKNTRVSKESLNKSVNIFNRETDELTVISDSLNSKILHGINKDKMHTSCHKKAISIKKVFEDHFPIVTVSQLPAQQHPEYEIESTKEPTLLSFHTASGKKVKIMQESLDKVKNLFDETQYVRKTASFSQGSKPLKDSKKELTLAYEKIEVTASKCEEMQNFVSKETEMLPQQNYHMYRQTENLKTSNGTSSKVQENIENNVEKNPRICCICQSSYPVTEDSALAYYTEDSRKTCVRESSLSKGRKWLREQGDKLGTRNTIKIECVKEHTEDFAGNASYEHSLVIIRTEIDTNHVSENQVSTLLSDPNVCHSYLSQSSFCHCDDMHNDSGYFLKNKIDSDVPPDMKNAEGNTISPRVSATKERNLHPQTINEYCVQKLETNTSPHANKDVAIDPSLLDSRNCKVGSLVFITAHSQETERTKEIVTDNCYKIVEQNRQSKPDTCQTSCHKVLDDSKDFICPSSSGDVCINSRKDSFCPHNEQILQHNQSMSGLKKAATPPVGLETWDTSKSIREPPQAAHPSRTYGIFSTASGKAIQVSDASLEKARQVFSEMDGDAKQLSSMVSLEGNEKPHHSVKRENSVVHSTQGVLSLPKPLPGNVNSSVFSGFSTAGGKLVTVSESALHKVKGMLEEFDLIRTEHTLQHSPIPEDVSKILPQPCAEIRTPEYPVNSKLQKTYNDKSSLPSNYKESGSSGNTQSIEVSLQLSQMERNQDTQLVLGTKVSHSKANLLGKEQTLPQNIKVKTDEMKTFSDVPVKTNVGEYYSKESENYFETEAVESAKAFMEDDELTDSEQTHAKCSLFTCPQNETLFNSRTRKRGGVTVDAVGQPPIKRSLLNEFDRIIESKGKSLTPSKSTPDGTVKDRSLFTHHMSLEPVTCGPFCSSKERQGAQRPHLTSPAQELLSKGHPWRHSALEKSPSSPIVSILPAHDVSATRTERTRHSGKSTKVFVPPFKMKSQFHGDEHFNSKNVNLEGKNQKSTDGDREDGNDSHVRQFNKDLMSSLQSARDLQDMRIKNKERRHLRLQPGSLYLTKSSTLPRISLQAAVGDRAPSACSPKQLYIYGVSKECINVNSKNAEYFQFDIQDHFGKEDLCAGKGFQLADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISSIWVANHYRWIVWKLAAMEFAFPKEFANRCLNPERVLLQLKYRYDVEIDNSRRSALKKILERDDTAAKTLVLCISDIISPSTKVSETSGGKTSGEDANKVDTIELTDGWYAVRAQLDPPLMALVKSGKLTVGQKIITQGAELVGSPDACAPLEAPDSLRLKISANSTRPARWHSRLGFFRDPRPFPLPLSSLFSDGGNVGCVDIIVQRVYPLQWVEKTVSGLYIFRSEREEEKEALRFAEAQQKKLEALFTKVHTEFKDHEEDTTQRCVLSRTLTRQQVHALQDGAELYAAVQYASDPDHLEACFSEEQLRALNNYRQMLNDKKQARIQSEFRKALESAEKEEGLSRDVTTVWKLRVTSYKKKEKSALLSIWRPSSDLSSLLTEGKRYRIYHLAVSKSKSKFERPSIQLTATKRTQYQQLPVSSETLLQVYQPRESLHFSRLSDPAFQPPCSEVDVVGVVVSVVKPIGLAPLVYLSDECLNLLVVKFGIDLNEDIKPRVLIAASNLQCQPESTSGVPTLFAGHFSIFSASPKEAYFQEKVNNLKHAIENIDTFYKEAEKKLIHVLEGDSPKWSTPNKDPTREPHAASTCCASDLLGSGGQFLRISPTGQQSYQSPLSHCTLKGKSMPLAHSAQMAAKSWSGENEIDDPKTCRKRRALDFLSRLPLPSPVSPICTFVSPAAQKAFQPPRSCGTKYATPIKKEPSSPRRRTPFQKTSGVSLPDCDSVADEELALLSTQALTPDSVGGNEQAFPGDSTRNPQPAQRPDQQVGPRSRKESLRDCRGDSSEKLAVES

Gene
Brca2
Protein
Breast cancer type 2 susceptibility protein homolog
Organism
Drosophila melanogaster
Length
971 amino acids
Function
Involved in and required for double-strand break repair by meiotic and mitotic homologous recombination. During meiosis, has a dual role in the repair of meiotic double-stranded breaks and the efficient activation of the meiotic recombination checkpoint.
Mass
108.649 kDa
Sequence
MDQNGASGSHPNRLSQGRGAHARERGATVSAAANRSNIIDEMAKICEADRQTFAIARRTRGHERLAVDNSDFVAVEDLILSYAEPTPEDQVEMIMSDFCSSPTYAEDEDEPSHESEPWFRFRNKRIRTYSRKRDPKSHKAVQNEKRRGSSGLSVQRDLNTSFTSMACDFDASSQKIHEVLLNLSQYFSATATASGPTPVPSQIDLPTEARQDSGDECFNAELENLRDDLLQSGFTFEASFYENEHEQEGPGTMADTIYGDSMQSVPTTRLRLESGKRNVWSDADSTLKKADVEIAENKKLLMGQTQAKNVDIEENTNFILEGIPLSEWLTPMELPEISKDVIKHIPDKKLKLEPSSQKEQKSSKDSNASKVRGASKQSCDINTKNEGTTILDQPNAAEQENLLNDGELLEEFLFNDWQPMQCSNGPSTSKNAIQGPKENINSINLDDKEQPEKQTPNKSQTISSHQLNGIRKKSFKFIEVSEEMKIKGEEFVDKVVSGLYHFSHKCNLRTEEYSDNHSQVMESTQCAEFKSAPSKPIEILDGKETYNAIAKVDVGEINGKFSPLNNDTIAEPEFCGFRTASNKAIPISEKMKIKTAEFMAEFQSKETIQQNDYLVHQPNDKPTSVGLDTALKRSIESSEEMRSKASKLVVVDTTMREPHQPTLDPVCRDLNESQFFGFRTASNKAIEITEAMEKRGAMFLAQSKATDQLNGWQPSDFPDVLPTSPNNEIHSINVENNKAVNTKTVSETEFFGFRTASNKGIVISENTKIKVAQFMSEFQAADASTDSNQPTVISEESRNIDAKFVDEAAAEDSANKPTFCNVQSLKNTSDIEHFKHDFFVEHSAKEEHPLCSQPLVRTPRRSQEIHSSLSQLAGKSPLDQATKKSVIARRNLLSLKRKRKIILSTETSTSCALPTMERFAPKPSSTSTPLADRDLNRSKDCTKNRQDAEDMSPICMQPKKSRRLGLSRSRY

Gene
Brca2
Protein
Breast cancer type 2 susceptibility protein homolog
Organism
Drosophila simulans
Length
944 amino acids
Function
Involved in and required for double-strand break repair by meiotic and mitotic homologous recombination. During meiosis, has a dual role in the repair of meiotic double-stranded breaks and the efficient activation of the meiotic recombination checkpoint (By similarity).
Mass
105.728 kDa
Sequence
MDQNGASGSRPNRLSQGKEAYACERSATVSAAADRSNIINEMAKICEADRQTSAIARRTQVHERLAVANSDFVAVEDLILAYAEPTPEDQVEMIMRDFCSSPTYEEDEDEPSYESEPWFRFRNKRIRTYSRKRDPKSYMAVRTEKSSGTSGLSVQRDLNTSSTSVACDFDAASSQKIHEVLLNLSQYFSATAKASSPTPVPSQIDLPTEARQDSGDECFNAEVENLRDDLLQNGFTFEASIYDNEHEQEDSGKFNVCSDADSTPKKTDVEIAEHKKHLKGPTQAEHVGKEENTNFILEGIPLSEWLTPMEPPKISKDVIKNIPDKKVKLEPSSQKEQKSSKDSNESKIRAASCDITKKNEGTTVLDQPNAAQQENLSNDGDLLEEFLFNEWHPMQCSNGPSTSNDAIKVPKEEINSIKRNDEEQPEKETPNKSRSTSSHQLSFRKTFLKFIEISGEMKIKGEKFVEKVVSGLHHPSHKCNLRTEEYSDNHSQVMESTQRVEFKSALSKPIELLDEKETYDMLAKVEVGEINGKCSPLNNETIAEPEFCGFRTASNKAIPISEKMKIKTAEFMAEFQSKETNHQNDYLVNQPNDNSTSVGRDTAFKKSIEISEEMPTKASKLVVVDTTLGEPHQPKIDPVCSDLNESQFFGFRTASNKAIEITEAMEKRGAMFLAQSRATDQQAEWQPSDFPDIPHTSPKNEIHSINVENTKAVHTKTASETEFFGFRTASNKGIVISENTKKKVAQFMSEFQAADASTDSNKPIVISEESRNIAAKFVDEAATEDSPNKPTFCNVQSQENPLDIEHFKHDLFVERSAKEEHPLCSQPLVRTPRRSQEIHSSLSQLAGQSPLDQATKKSVIARRNLLSLKRKRKIVSSTETSTSCASPAMERFAPKPSSTSTPLADRDLNRSKDCAKNRQDAEDMSPICMQPKKSRRLGLSRSRY

Gene
Brca2
Protein
Breast cancer type 2 susceptibility protein homolog
Organism
Drosophila sechellia
Length
938 amino acids
Function
Involved in and required for double-strand break repair by meiotic and mitotic homologous recombination. During meiosis, has a dual role in the repair of meiotic double-stranded breaks and the efficient activation of the meiotic recombination checkpoint (By similarity).
Mass
105.452 kDa
Sequence
MDQKGASGSRPNRLSQGKEAYACERSATVSVAANRNNIINEMAKICEADRQTSAIARRTQVHERLAVANSDFVAVEDLILAYAEPTPEDQVEMIMRDFCSSPTYEEDEDEPSFESEPWFRFRNKRIRTYSRKRDPRSYMAVRTEKPRGTSGLSVQRDLNTSFTSMACDFDAASSQKIHEVLLNLSQYFSATAKTSSPTPVPSQIDLPTEARQDSGKECFNAEVENLRDDLLQNGFTFEASIYDNEHEQEGSEKFNVCSDAEIAEHKKLLKGPTQAEHVGKEENPNFILEGIPLSEWLTPMEPPMISKDVIKNIPDKKVKLEPSFQKEQKSSKDSNESKIRAPSKPSCDITEKNEGTTVLDQPYAAQQENLSNDGDLLEEFLFNEWHPMQCSNGPSTSNDAIQVPKEEINSIKRTDEEQPEKETPNKSRSTSSHQLSFRKTSLKFIEISEEMKIKGEKFVDKVISGLYHPSHKCNLRTEEYSDNHSQVMESTQCVEFKSALNKPIELLDKKETYDMLAKVEVGEINGKCSPLNNEAIAEPEFCGFRTASNKAIPISEKMKIKTAEFMAEFQYKETNHQNDYLVNQPNDNSTSVGLDTVLKKSIEISEEMPTKASKLVVVDTRLGEPHQPTLDPVCSDLNEPQFFGFRTASKKAIEITEAMEKRGAMFLAQSRATDQQAEWQPSDFPDIPHTSPKNEIHSINVENNKAVHTKTASETEFFGFRTASNKGIVISENTKMKVAQFMSEFQAADASTDSNKPIVISEEPSNIAAKFVDEAAAEDSPSKSTFCNVQSQENPLNIEHFKHDLFVKRSAKEEHPLCSQPLVRTPRRSLEIHSSLSQLAGQSPLDQATKKSVIARRNLLSLKRKRKIVSSTETSTSCASPDMERFAPKPSSTSTPLADRDLNRSKDCAKNRQDAEDMSPICMQPKKSRRLGLSRSRY