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Bola2

Gene
BOLA2
Protein
Protein BOLA2
Organism
Arabidopsis thaliana
Length
93 amino acids
Function
May act either alone or in interaction with glutaredoxin as a redox-regulated transcriptional regulator, or as a factor regulating Fe-S cluster biogenesis (Probable). The GRXS17-BOLA2 heterodimer binds a labile, oxygen sensitive iron-sulfur cluster (PubMed:24714563).
Similarity
Belongs to the bolA/yrbA family.
Mass
10.375 kDa
Sequence
MVTKEQVEASLTSKLKPIHLEVIDISGGCGSSFEVEVVSEQFEGKRLLERHRMVNAALEEEMKEIHALSIKKAQTPQQWKPPSQDSATLTKDA

Gene
Bola2
Protein
BolA-like protein 2
Organism
Mus musculus
Length
86 amino acids
Function
Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts together with the monothiol glutaredoxin GLRX3.
Similarity
Belongs to the BolA/IbaG family.
Mass
10.215 kDa
Sequence
MELSADYLREKLRQDLEAEHVEVEDTTLNRCATSFRVLVVSAKFEGKPLLQRHRLVNECLAEELPHIHAFEQKTLTPEQWTRQRRE

Gene
BOLA2
Protein
BolA-like protein 2
Organism
Homo sapiens
Length
86 amino acids
Function
Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts together with the monothiol glutaredoxin GLRX3 (PubMed:26613676, PubMed:27519415).
Similarity
Belongs to the BolA/IbaG family.
Mass
10.117 kDa
Sequence
MELSAEYLREKLQRDLEAEHVEVEDTTLNRCSCSFRVLVVSAKFEGKPLLQRHRLVNACLAEELPHIHAFEQKTLTPDQWARERQK