Protein
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
Organism
Bovine herpesvirus 4 (strain V. test)
Function
Non-essential glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans. Contributes to the post-translational modifications of structural proteins.
Similarity
Belongs to the glycosyltransferase 14 family.
Sequence
MKMAGWKKKLCPGHHLWALGCYMLLAVVSLRLSLRFKCDVDSLDLESRDFQSQHCRDMLYNSLKLPAKRSINCSGITRGDQEAVVQALLDNLEVKKKRPPLTDTYYLNITRDCERFKAQRKFIQFPLSKEELDFPIAYSMVVHEKIENFERLLRAVYAPQNIYCVHVDVKSPETFKEAVKAIISCFPNVFMASKLVPVVYASWSRVQADLNCMEDLLQSSVSWKYLLNTCGTDFPIKTNAEMVLALKMLKGKNSMESEVPSESKKNRWKYRYEVTDTLYPTSKIKDPPPDNLPMFTGNAYFVASRAFVQHVLDNPKSQILVEWVKDTYSPDEHLWATLQRAPWMPGSVPSHPKYHISDMTAIARLVKWQYHEGDVSMGAPYAPCSGIHRRAICIYGAGDLYWILQNHHLLANKFDPRVDDNVLQCLEEYLRHKAIYGTEL