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Beas

Gene
Beas
Protein
Beauvericin nonribosomal cyclodepsipeptide synthetase
Organism
Beauveria bassiana
Length
3189 amino acids
Function
Beauvericin nonribosomal cyclodepsipeptide synthetase; part of the gene cluster that mediates the biosynthesis of beauvericin (BEA), a non-ribosomal cyclic hexadepsipeptide that shows antibiotic, antifungal, insecticidal, and cancer cell antiproliferative and antihaptotactic activity (PubMed:18804027, PubMed:28534477). Ketoisovalerate reductase BEA2 catalyzes the NADPH-specific reduction of ketoisovaleric acid to hydroxyisovalerate, a precursor for beauvericin biosynthesis (By similarity). The nonribosomal cyclodepsipeptide synthetase BEA1 then catalyzes the formation of beauvericin via condensation and cyclisation of 3 dipeptidol monomers, each composed of one unit of hydroxyisovalerate and one unit of N-methyl-phenylalanine (PubMed:18804027, PubMed:28534477).
Similarity
Belongs to the NRP synthase family.
Mass
351.91 kDa
Sequence
MEPLKNVNTGQPCSTVPFPVSDETVEHLNGLYEEINRRFGLDRDAIETILPCTPFQYDVLDCAANDARHAVGHAMYEISQHVHVQRFIAAWRETVRRTPALRACTFTSTTGESFQLVLRESFVLSRIYWSSSSSLQAAVLKDETTAAIAGPRCNRLVLLEDPDTRKQLLIWVFHLALVDSTVQEPILRRVLAAYKSEDDQLDSLPLTPDSSGGSDSDSPSTLKMPRAFDQEKATQFWQRQLSGLDASVFPPLSSHLTTPKADAKIEHYISWPASAAQHRWSSTTVCQAALAVLLSRYSHSSEALFGVVTEQVCMFEGQRLLINGPTRSVVPFRVHCGPEQSVTDLLKSIASDNHDMRQFAHVGLCNISRIGDDQSAACRFQTVLSVSNRRSSEDAASGEVLQILQESEGFAPCADRALLLRCETSRQGALLVARYDQGVIEPPQMARFLRQLGWLMEQLQSAADDALSVKQLDIVTREDRAEIDSWNSDALEVQESLLHSAFVKRAAESPSDPAVLSWDGAWTYSELDNVSSRLAAHIRSLDLSHEQLIVPVYFEKSKWVVASILAVLKAGHAFTLIDPKDPPARTTRIVQQTSAKVALTSKLHQDTVQAIIGRCIVVDDDFVQSLGSASQCQEKSELTVKPHNLAYAIFTSGSTGDPKGIMIEHQAFASCVAKFGPALIPHNARALQFASHGFGACLLEILPTLLRGGCVCIPSDLDRMHNIPDFIRRYNVNWMMATPSYMTTFKPEDVPGLQTLILVGEQMSASVNATWASRLGLFDGYGQSESCSICFIGKISPVSEANNIGRAVGAHSWIVHPDDPDRLAPVGAVGELLIESPGIARGYIAAPATDRNPFLETAPAWYAPRQPPTGVKFYRTGDLARYAADGTVVCLGRIDSQVKIRGQRVEMGAVETRLRQQVPSDITVVAEAVKRSGSSGSTVITAFLIDSSDKNNSSAASAKDARILDQTATQEMNAKLCQVLPPHSVPSCYICMHALPRTATGKVDRKTLRSIGSKLLEQQAYKKSPETMQKSKSAETLETGPEARLKEVWLQSFNLEPASPKCGASFFELGGDSITAIKMVNMARAAGLELKVSDIFQNPTLARLQAVMSGDSTPSTITTPFATIPASTWDGPVEQSYSQGRLWFLDQLDIGAVWYLIPYAVRMRGALNIDALRAALLALEQRHETLRTTFENQNGVGVQIVHQRLAKELKIIDASSHGDDGYLQPLEQEQTTPFDLTCEAGWRASLICVGEDHHVLSIVMHHIVSDGWSIDVLRQELGQLYAAVLHGDEDPLSAVSPLPIQYRDFSMWQRRQQVAEHDRQLQYWRKQLADCSPAKLPTDFPRPPLLSGDAGSVPVEISGELFQKLHRFCNVTSTTPFAVLLAAFRAAHYRLTGVDDAVVGTPIANRNRPELERLIGFFVNTQCMRITVDDDDTFEGLVRQVRRTTTEAFENEDVPFERVVSAMLPAGGGSRDLSQTPLAQLIFAVHSQENLGKFELEGLESEPVANKAYTRFDAEFHLFQTRDGLNGYLNFAAELFKLETMQNVVSVFLQILRHGLEQPKSLISVLPLTDGLKELDSMGLLKIHRGLEYQRDSSLVDIFRSQVATCPDTIAVIDSSARLTYAQLDHQSNLLEAWIRRKGLPAESLVGVLSPRSCETIIAFLGILKANLAYLPLDPKSPVSRMRDVLSDLPGHTIILLGSDVAAPDLELPCLELVRISDALKSGASAVNGSETTDLSAPSANSLAYVLYTSGSTGRPKGVMVEHRAIVRLVQRGVIPNFPPLRGAIMAHLFNTVFDGATYEIFLMLLNGGTLVCIDYLTTLSPKALETVFLREGINCAIMTPALLKLYLANARDGLKGLDMLMVAGDRFDPQDAVEAQTLVRGDCYNAYGPTENGVMSTLYKIDTSDSFINGVPLGRAIDNSGAYITDPNQQLVGPGVLGELIVTGDGLARGYTDPALDRDRFVQVVINGESVRAYRTGDRMRYRAGQDCLFEFFGRMDFQFKIRSNRIESAEVEAAILSHPLVRDAAIVVVGVQEEQEPEMVGFVVAADDAVEQEATDNQVEGWQELFESSMYNGIDAISPSALGKDFTGWTSMYDGSEIDKSEMQEWLDDTIHTLRDGHVPGHVLEIGTGTGMILFNLGSVESYVGLEPTKSAVEFVNKAIKTLPNLAGRAEVHTGTATDIDQLSGLRPDLVILNSVVQYFPTVEYLTRVVDALVRIRGVKRLFFGDVRSQALHRQFLAACAMHALGKTATRDDVRRYMAEREEREEELLVEPAFFTALMNRHPNLIQHVEILPKNIRATNELSAYRYAAVVHLRDPESAARPVYPIAADDWVDFQASQMRSDVLREYLRLSAGADTVAVCNIPYEKTIFERLIVESLDDNTGSDAPQSRLHGRSLDGAPWISAVRSDAESRASLSVPDLVQLAAESGFQVQVSAARQWSQSGALDAVFHRRHASSSQPTMRTLFQFPDDNALRASATLTNRPLQRLQRRRVAAQIRERLQTLVPSYMIPAKIVVLDQMPLNANGKVDRKELARRARTTTMTKKKKPQRLASEPACPISDIEVALCEEATATFGMQVGISDHFFKLGGHSLLATKLISRVGDRLKARLTVKDVFDHPIFSELAIVIREGLQNVVPVALNGGGQAKQGSAGVVAPRNEMETMLCEEFANVLGMDVGVTDNFFDLGGHSLMATKLAARIGRRLNTTISVKEVFEHPIVFQLANSLELGQLESDRVKHTMLADYTAFQLLSVEDLQGFLQNEISPQLECAHGGIQDVYPATHMQKAFLCDASTGHPKPLVPFYIDFPPDSDCSTLVEACSSLVKRFDMFRTVVVEAAGELYQVVLEHFDLQIDVVETEENVHAATNDFVDRILEVPVHLGQPLIQFTILKQASSVRVLLCLSHALYDGLSLEHVVRDLHMLYKGRSLLPANQFSRYMQYMDHTRKAGCDFWRDVIQDTPITVLGHVDAGGRELEVEAARTLHATKIISIPLQAVRSSIITQATVFNAACALVLSRETGAKDVVFGRIVSGRQGLPVSWQNIVGPCTNAVPVRARIIDDDDDNHRQMLRDMQDQYLLSLPFETLDFDEVRRSCTNWPATANNYACCVTYHDFSYHPESEMEQQRVEMGVLARKDALLKEEPVYDLGIAGEVEPDGVHLQVTVVAKTRLFSEERAAYLMEEVCRLFESLNSAL