Function
Essential protein (PubMed:20675571, PubMed:25452667). Negatively regulates the response to iron deficiency and thus contributes to iron homeostasis (PubMed:20675571, PubMed:25794933). Exhibits E3 ubiquitin-protein ligase activity in vitro (PubMed:24253678, PubMed:25452667). Plays a role in root growth, rhizosphere acidification, and iron reductase activity in response to iron deprivation (PubMed:25452667, PubMed:27359166). Facilitates 26S proteasome-mediated degradation of PYEL proteins in the absence of iron (PubMed:25452667).
Sequence
MATPLPDFETARGGGAVASSSTTVLPSSVSSSSSSSRPLPVANSFSDDAEEISPILIFLFFHKAVCSELEALHRLALEFATGHHVDLRLLRERYRFLRSIYKHHCNAEDEVIFSALDIRVKNVAQTYSLEHKGESNLFDHLFELLNSATETDESYRRELARSTGALQTSVSQHLAKEQKQVFPLLIEKFKYEEQAYIVWRFLCSIPVNMLAVFLPWISSSISVDESKEMQTCLKKIVPGEKLLQQVIFTWLGGKSNTVASCRIEDSMFQCCLDSSSSMLPCKASREQCACEGSKIGKRKYPELTNFGSSDTLHPVDEIKLWHKSINKEMKEIADEARKIQLSGDFSDLSAFDERLQYIAEVCIFHSLAEDKIIFPAVDGEFSFSEEHDEEENQFNEFRCLIENIKSAGASSTSAAEFYTKLCSHADQIMETIQRHFHNEEIQVLPLARKNFSFKRQQELLYQSLCIMPLRLIERVLPWLTASLTEDEAKNFLKNLQAGAPKSDVALVTLFSGWACKGRKAGECLSPNGNGLCPVKTLSNIKEVNLQSCNACASVPCTSRSTKSCCQHQDKRPAKRTAVLSCEKKTTPHSTEVANGCKPSGNGRSCCVPDLGVNNNCLELGSLPAAKAMRSSSLNSAAPALNSSLFIWEMDSNSFGTGHAERPVATIFKFHKAISKDLEFLDVESGKLIDCDGTFIRQFIGRFHLLWGFYKAHSNAEDDILFPALESKETLHNVSHSYTLDHKQEEKLFGDIYSVLTELSILHEKLQSDSMMEDIAQTDTVRTDIDNGDCNKKYNELATKLQGMCKSIKITLDQHIFLEELELWPLFDKHFSIQEQDKIVGRIIGTTGAEVLQSMLPWVTSALSEDEQNRMMDTWKQATKNTMFDEWLNECWKGSPDSSSTETSKPSPQKDNDHQEILDQSGELFKPGWKDIFRMNQNELEAEIRKVYQDSTLDPRRKDYLVQNWRTSRWIAAQQKLPKEAETAVNGDVELGCSPSFRDPEKQIYGCEHYKRNCKLRAACCDQLFTCRFCHDKVSDHSMDRKLVTEMLCMRCLKVQPVGPICTTPSCDGFPMAKHYCSICKLFDDERAVYHCPFCNLCRVGEGLGIDFFHCMTCNCCLGMKLVNHKCLEKSLETNCPICCEFLFTSSEAVRALPCGHYMHSACFQAYTCSHYTCPICGKSLGDMAVYFGMLDALLAAEELPEEYKNRCQDILCNDCERKGTTRFHWLYHKCGSCGSYNTRVIKSETIPPDCSTSS