BNI1

Protein BNI1

1953 amino acids

Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and acts as leaky capper, slowing both polymerization and depolymerization. Protects the growing actin fiber from tight capping proteins and so increases the time of elongation and the total amount of F-actin. May organize microtubules by mediating spindle positioning and movement in the budding process. Potential target of the RHO family members.

Belongs to the formin homology family. BNI1 subfamily.

219.673 kDa

MLKNSGSKHSNSKESHSNSSSGIFQNLKRLANSNATNSNTGSPTYASQQQHSPVGNEVSTSPASSSSFRKLNAPSRSTSTEARPLNKKSTLNTQNLSQYMNGKLSGDVPVSSQHARSHSMQSKYSYSKRNSSQASNKLTRQHTGQSHSASSLLSQGSLTNLSKFTTPDGKIYLEMPSDPYEVEVLFEDIMYKRNIFQSLSEDKQEALMGYSIEKKWLIVKQDLQNELKKMRANTTSSSTASRTSMASDHHPILTANSSLSSPKSVLMTSASSPTSTVYSNSLNHSTTLSSVGTSTSKGKKLVSGSLKKQPSLNNIYRGGAENNTSASTLPGDRTNRPPIHYVQRILADKLTSDEMKDLWVTLRTEQLDWVDAFIDHQGHIAMANVLMNSIYKTAPRENLTKELLEKENSFFKCFRVLSMLSQGLYEFSTHRLMTDTVAEGLFSTKLATRKMATEIFVCMLEKKNKSRFEAVLTSLDKKFRIGQNLHMIQNFKKMPQYFSHLTLESHLKIIQAWLFAVEQTLDGRGKMGSLVGASDEFKNGGGENAILEYCQWTMVFINHLCSCSDNINQRMLLRTKLENCGILRIMNKIKLLDYDKVIDQIELYDNNKLDDFNVKLEANNKAFNVDLHDPLSLLKNLWDICKGTENEKLLVSLVQHLFLSSSKLIEENQNSSKLTKQLKLMDSLVTNVSVASTSDEETNMNMAIQRLYDAMQTDEVARRAILESRALTKKLEEIQAERDSLSEKLSKAEHGLVGQLEDELHERDRILAKNQRVMQQLEAELEELKKKHLLEKHQQEVELRKMLTILNSRPEESFNKNEGTRGMNSSLNSSEKANIQKVLQDGLSRAKKDYKDDSKKFGMTLQPNKRLKMLRMQMENIENEARQLEMTNFAEFEKDRLEPPIHIKKPKVKKMKNKDRKPLVKPQEADVNKLNDLRRALAEIQMESNDISKFNVEERVNELFNEKKSLALKRLKELETKYKGFGIDFNVDEIMDSPKKNTGDVETEEDANYASLDPKTYQKKLDEINRITDQLLDIQTQTEHEIQVEEDGESDLSSSSSDDESEEIYQDASPTQELRSEHSELSSGSGPGSFLDALSQKYGTGQNVTASAAFGENNNGSGIGPLHSKVEKTFMNRLRKSTVSSAPYLEELTQKVNKVEPYEQNEDEGLDKKSLPENSTASAASAFDKAEKDMRQHVENGKQGRVVNHEEDKTADFSAVSKLNNTDGAEDLSTQSSVLSSQPPPPPPPPPPVPAKLFGESLEKEKKSEDDTVKQETTGDSPAPPPPPPPPPPPPMALFGKPKGETPPPPPLPSVLSSSTDGVIPPAPPMMPASQIKSAVTSPLLPQSPSLFEKYPRPHKKLKQLHWEKLDCTDNSIWGTGKAEKFADDLYEKGVLADLEKAFAAREIKSLASKRKEDLQKITFLSRDISQQFGINLHMYSSLSVADLVKKILNCDRDFLQTPSVVEFLSKSEIIEVSVNLARNYAPYSTDWEGVRNLEDAKPPEKDPNDLQRADQIYLQLMVNLESYWGSRMRALTVVTSYEREYNELLAKLRKVDKAVSALQESDNLRNVFNVILAVGNFMNDTSKQAQGFKLSTLQRLTFIKDTTNSMTFLNYVEKIVRLNYPSFNDFLSELEPVLDVVKVSIEQLVNDCKDFSQSIVNVERSVEIGNLSDSSKFHPLDKVLIKTLPVLPEARKKGDLLEDEVKLTIMEFESLMHTYGEDSGDKFAKISFFKKFADFINEYKKAQAQNLAAEEEERLYIKHKKIVEEQQKRAQEKEKQKENSNSPSSEGNEEDEAEDRRAVMDKLLEQLKNAGPAKSDPSSARKRALVRKKYLSEKDNAPQLLNDLDTEEGSILYSPEAMDPTADTVIHAESPTPLATRGVMNTSEDLPSPSKTSALEDQEEISDRARMLLKELRGSDTPVKQNSILDEHLEKLRARKERSIGEASTGNRLSFK

BNI1

Formin BNI1

1732 amino acids

Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and acts as leaky capper, slowing both polymerization and depolymerization. Protects the growing actin fiber from tight capping proteins and so increases the time of elongation and the total amount of F-actin. May organize microtubules by mediating spindle positioning and movement in the budding process. Required for the maintenance of polarized hyphal growth. BNI1-mediated actin cables are necessary for positioning the Golgi complex to a putative site of germ tube emergence and for coordinating the transport and deposition of membrane and cell wall material to a growing hypha. Plays a key role in virulence.

Belongs to the formin homology family. BNI1 subfamily.

196.794 kDa

MRRRHKDKHNTDSVSDMSSNDSASILSSASQNSTHSRRSASLQSLHSQSHQYPQGHNNSSHRQASTYSISSLSPYDKGASLSRKSTNISISRPIKTNDSNVFPIKQSFQLERPNSAFEIERMFRELLEKLNFKSLPPQATREMLNYDIDRKWMMIEQDARAEYDRQQRYARAQNIFSPEEYAKVLMSKQVSTNQLSGLWLALRSEPIDWVRRFVYDCQGDTLLSVYLTKLQQEMVSCNITDIEDDIFDKEVNVLQSLKCLMNQRLGAERIKTDVDVFVNAVSGSLLSPRIITRKLATDTLTFMISYNGNNDNGRYHKVLRALDSINEKSRMEFDSPDNYSPRKLTRKPPQPANFKRFELWLNVVEKTIDARGKFRNSDVGASDELKSAYAGTRGSVITTRNQLENHLVEYCIATMLLINVIVGNGTDYRVRIHLRAQFRAAGLDRIIHKFLELGNEELDNMITRHKIDANNDEEELKYSANFNNEDNEVDFNDPVNLVQSLWQSVKNSDAEGYFLSAIQHLFLNQSEKRGNPEEMNRSLRVLDGLIQNISSVRTVSEDTAINVAINKLISNMSTDDMYRKALEDVKIYRRIAEEATAERDDMSRQLSMGADGYINSLLNDVKERDMVISRFRRINEDMKEELEQMKTKYMQEKQESELEMRELLIMLNNSEIGANAVKKDGGKTTISISTSNEELAARLKKQIHRRRAEYKLDNRQLGTNVEPSSRLRALRDQMGDIENMARELEMTDFETYADPEEEENNNDQSPEKSEIDESRSSQESEAEIQSVEEDEEEEEKEVVIPPLPVPSGPKRAVRNDDLVRLDHLRKKLANLQSESNDIMKYNSSSMFNKQKFLAMERLQELENNFKDFNIDFAVSDPEDKYNFNSNAGSVDDSIKNKTKEVLAEAEQIREELRRQLAAAQKIKSPSPKRNTVLERIENKYVKGQVKIDAPDVVSNSPRTQKRAHRSTTLNAMDPKFLQELSLKVGKAEPIQDANNKNQFGGPLSSSPEDVSQKHKTSGDSSDKDKVLSSPISSNDIKSPETGNSTTSSAAPPPPPPPPPPPPPPLPPILGGNNSSAAPPPPPPPPPPPAFLNGSGSVIPPAPPLPPPSSGRSSRSVPSTVTKSSGSAFDKIPRPKKKLKQLHWEKIDHSQVGNSFWNDPNTHTLVDDLMSKGIFDEIELIFAAKEAKKLATKKKEDLDKVTFLARDISQQFSINLHAFNSFSDEEFVLKVLRCDKDVLTNPAVLDFFGKEDIVEITNTLARNFEPYSTDYKTEEITKPEKDPNELQRPDRIYLELMYNLQHYWKSRTRALNVVVNYDKDYVEYVKKLRLIDEAVDSIKNSKHLKGVFEIILAVGNYMNDSAKQAHGFKLSSLQRLSFMKDEKNSMTFLHYVEKVIRTQYPEFLEFINELSCCNEITKFSIENINNDCKEYARAIKNVQSSIDIGNLSDVSKFHPSDRVLKAVLPALPRAKRKAELLLDQANYTMKEFDDLMKYFGEDPTDQFVKNSFISKFTDFMKDFKRVQAENIKREEELRVYEQRKKLLEKPKSSNNGDSNASDQDGESNEGDGGVMDSLLQRLKAAAPTKGESASARKKALMRKQILESQRKRTTGSVGSPTNVSPTRNNESDSGVDNKDDTHGSSPLDEQFHDSITTQEDRIRDDNRPPEGVADFSNVEDPENPDVGARAKNLLQELRGADESSSKLSDAQRYRQERLKKKSVQIDLDEVAKNNNSE