Protein
Cytochrome P450 CYP107DY1
Organism
Bacillus megaterium (strain ATCC 12872 / QMB1551)
Function
Cytochrome P450 whose physiological substrate is unknown. In vitro, is able to catalyze the selective hydroxylation of mevastatin to pravastatin, the widely used therapeutic agent for hypercholesterolemia.
Similarity
Belongs to the cytochrome P450 family.
Sequence
MKKVTVDDFSSPENMHDVIGFYKKLTEHQEPLIRLDDYYGLGPAWVALRHDDVVTILKNPRFLKDVRKFTPLQDKKDSIDDSTSASKLFEWMMNMPNMLTVDPPDHTRLRRLASKAFTPRMIENLRPRIQQITNELLDSVEGKRNMDLVADFSFPLPIIVISEMLGIPPLDQKRFRDWTDKLIKAAMDPSQGAVVMETLKEFIDYIKKMLVEKRNHPDDDVMSALLQAHEQEDKLSENELLSTIWLLITAGHETTAHLISNGVLALLKHPEQMRLLRDNPSLLPSAVEELLRYAGPVMIGGRFAGEDIIMHGKMIPKGEMVLFSLVAANIDSQKFSYPEGLDITREENEHLTFGKGIHHCLGAPLARMEAHIAFGTLLQRFPDLRLAIESEQLVYNNSTLRSLKSLPVIF