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BMP2

Gene
bmp2
Protein
Bone morphogenetic protein 2
Organism
Tetraodon nigroviridis
Length
420 amino acids
Function
Induces cartilage and bone formation.
Similarity
Belongs to the TGF-beta family.
Mass
47.625 kDa
Sequence
MVAVVRSLMVLLLAQVLLEGATGLIPEVGRRRYSESGKQSPQQSEGFLNEFELRLLNMFGLKRRPTPSKQAVVPQYMVDLYRMHSANGDHSAKRPKSMGRHAERAASKANTIRSFHHEESMEALARLKGKTTQQFYFNLTSIPKEELITSAELRIYRDQVMGAASTNNSSTNSSTSDKAHAGGFHRINIYEIFGVPQGREPLARLLDTRLVQDSLTRWESFDVSSAVFQWTSGKGHNHGFMIEVLHPEEGEVEQERADKHSRHVRVSRSLHQDRDSWPQARPLLVTYGHDGRGDSVLHTREKRQAALRKQRRKHQHKASCKRHALYVDFSDVGWNEWIVAPPGYHAFYCQGECPFPLADHLNSTNHAIVQTLVNSVNSNIPRACCVPTDLSPISLLYLDEYEKVILKNYQDMVVEGCGCR

Gene
BMP2
Protein
Bone morphogenetic protein 2
Organism
Dama dama
Length
396 amino acids
Function
Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased exoression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.
Similarity
Belongs to the TGF-beta family.
Mass
44.646 kDa
Sequence
MVAGTRCLLALLLPQVLLGGAAGLIPELGRRKFAASWPGRSSSQPSDDVLSEFELRLLSMFGLKQRPTPSRDPVVPPYMLDLYRLHSGQPGAPAPGHRLERAASLANTVRTFHHEESLEELPEMSGKTTRRFFFNLTSIPTEEFITSAELQVFGKHMPEALENNSSFHHRINIFEIIKPATANSKFPVTRLLDTRLVTQNASRWESFDVTPAVMRWTAQGLTNHGFVVEVAHPEDSYGASKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHRREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR

Gene
BMP2
Protein
Bone morphogenetic protein 2
Organism
Homo sapiens
Length
396 amino acids
Function
Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
Similarity
Belongs to the TGF-beta family.
Mass
44.702 kDa
Sequence
MVAGTRCLLALLLPQVLLGGAAGLVPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRANTVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR

Gene
BMP2
Protein
Bone morphogenetic protein 2
Organism
Oryctolagus cuniculus
Length
395 amino acids
Function
Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.
Similarity
Belongs to the TGF-beta family.
Mass
44.664 kDa
Sequence
MVAGTRCLLALLLPQVLLGGAAGLIPELGRRKFAASSGRPSPQPSDDILSEFELRLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQPGAPAPDHRLERAASRANTVRSFHHEESLEELPETSGKTTRRFFFNLTSIPPEEFITSAELQVFREQMQEALGDDSGFHHRINIYEIIKPATANSKFPATRLLDTRLVNQNTSRWESFDVTPAVMRWTAQGHANHGFVVEVTHLEEKQGVSKRHVRISRSLHPDEHSWSQIRPLLVTFGHDGKGHPLHRREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR

Gene
Bmp2
Protein
Bone morphogenetic protein 2
Organism
Mus musculus
Length
394 amino acids
Function
Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.
Similarity
Belongs to the TGF-beta family.
Mass
44.525 kDa
Sequence
MVAGTRCLLVLLLPQVLLGGAAGLIPELGRKKFAAASSRPLSRPSEDVLSEFELRLLSMFGLKQRPTPSKDVVVPPYMLDLYRRHSGQPGAPAPDHRLERAASRANTVRSFHHEEAVEELPEMSGKTARRFFFNLSSVPSDEFLTSAELQIFREQIQEALGNSSFQHRINIYEIIKPAAANLKFPVTRLLDTRLVNQNTSQWESFDVTPAVMRWTTQGHTNHGFVVEVAHLEENPGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR

Gene
Bmp2
Protein
Bone morphogenetic protein 2
Organism
Rattus norvegicus
Length
393 amino acids
Function
Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.
Similarity
Belongs to the TGF-beta family.
Mass
44.383 kDa
Sequence
MVAGTRCLLVLLLPQVLLGGAAGLIPELGRKKFAGASRPLSRPSEDVLSEFELRLLSMFGLKQRPTPSKDVVVPPYMLDLYRRHSGQPGALAPDHRLERAASRANTVLSFHHEEAIEELSEMSGKTSRRFFFNLSSVPTDEFLTSAELQIFREQMQEALGNSSFQHRINIYEIIKPATASSKFPVTRLLDTRLVTQNTSQWESFDVTPAVMRWTAQGHTNHGFVVEVAHLEEKPGVSKRHVRISRSLHQDEHSWSQVRPLLVTFGHDGKGHPLHKREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR

Gene
BMP2
Protein
Bone morphogenetic protein 2
Organism
Gallus gallus
Length
353 amino acids
Function
Negatively regulates the structure and function of the limb apical ectodermal ridge.
Similarity
Belongs to the TGF-beta family.
Mass
40.347 kDa
Fragment
single
Sequence
GSLKRPEDLLGEFELRLLHMFGLKRRPSPGKDVVIPPYMLDLYRLHAGQQLGYPLERAACRANTVCSFHHEEVLEELPETSGKTARRFFFNLTSIPNEESVTSAELQIFPGEQVHEAFESNSSYHHRINIYEIMKPATATSKDPVTRLLDTRLVHHNASKWESSDVTPAVLRWIAHGQPNHGFVVEVVHLDKENSASKRHVRISRSLHQDEDSWSQLRPLLVTFGHDGKGHPLHKREKRQAKHKQRKRHKYSCKRHPLYVDFNDVGWNDWIVAPPGYSAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR