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BH3067

Gene
BH3067
Protein
dITP/XTP pyrophosphatase
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Length
194 amino acids
Function
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Similarity
Belongs to the HAM1 NTPase family.
Mass
21.868 kDa
Sequence
MKEWIVATKNKGKVAEFEAILGKRGFSVKSLLDYPAIEDIEETGSTFNENATIKAEAIAERFQRPVLADDSGLIIDALDGRPGIFSARYAGEEKDDQKNIEKVLRELQDIPWKARTARFHCSIALARPQAETIVFEGTCEGYITTEPKGTGGFGYDPIFYVPSHDKTMAELTQEEKNKLSHRYHALKQLDKWLD