Protein
GTPase-activating protein BEM3
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Function
GTPase-activating protein (GAP) for CDC42 and less efficiently for RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase (By similarity).
Sequence
MGDGSDAERSGGTSSSSALELLAQYEQHIMERGRTLEAIEGHGGERLGPTYEELVEENVQLRRELQGQREEIEHLRKTISLLASGRSGATVVEQQVRPEPSPSVRELALPPRSADRRKNTKNLSLAPVGHEVPSTDRLRVSPQEATSGAQQVPLLTSSKSAEILVSKSPDEDRHLMSPRKTISRSSSSYSNTLGSPATSVLYKNSRISITSPCKSNSTSKAASVLSLPENNTSTENAPHSPHRIDNELDLLTVEPQDGSRYDTERAGGPGPLSPESIVYSDSDLQEHQPSDLSSTTRTDLGKFRDMVDTTFNAEDNPTGSRDKETGTEMEIATLQNTPSRQHESSLVTSPQASRSSITTPVVDPTNTSEPSSLSAAKFGSMSTATSSNKRSKGMGTPSVEHSAKSYSQHSGSPHSNSHQSKKADIPLFVQPEELGTIRIEVISTLYHEPGNAASILFSVVDKKSSKEMFKFAKTFTRIAEFDTFIRNNMESLAVPPLPDKHMFASNVPVKVDSRREKLNDYFASLLYLSPLPFNPALKLAQFISTDPVMNPITGEFAKEGMLLVRKSKTLGSTTTWRIRYCTVEGSIMHLHDHMIDTDTIKLTHSTIELQANLPDDKYGTKNGFILNEHKKSGLSSSTKYYFCAETPKEREQWISVLTTLCDGPGGTAAIPSINSKSEASSLFEQTSISDSSYLGPIANLEAMDATSPTRPNDPNPVSLTSEEEKEVKRRRMKSFFPFKKLATTPTPYAAGNDNASIFSQDDDSPVNATNESGISRSLQSMNLQAQYNAVFGADLRSCLQLSSHPYQGKYEIPSVVFRTLEFLYKNRGIQEEGIFRLSGSSSLIKSLQEQFDKEYDVDLCNYNDKVSVTPGNENQGGLYVDVNTVSGLLKLYLRKLPHMIFGDAAYMDFKRIVERNGDDSKLIALEFRALVNSGRIAKEYVALMYALFELLVKITENSKYNKMNLRNLCIVFSPTLNIPVNILHPFITDFGCIFQDKAPMENGPPVNIHIPQI