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BEA2

Gene
BEA2
Protein
Ketoisovalerate reductase BEA2
Organism
Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)
Length
452 amino acids
Function
Ketoisovalerate reductase; part of the gene cluster that mediates the biosynthesis of beauvericin (BEA), a non-ribosomal cyclic hexadepsipeptide that shows antibiotic, antifungal, insecticidal, and cancer cell antiproliferative and antihaptotactic activity (PubMed:27750383). Ketoisovalerate reductase BEA2 catalyzes the NADPH-specific reduction of ketoisovaleric acid to hydroxyisovalerate, a precursor for beauvericin biosynthesis (By similarity). The nonribosomal cyclodepsipeptide synthetase BEA1 then catalyzes the formation of beauvericin via condensation and cyclisation of 3 dipeptidol monomers, each composed of one unit of hydroxyisovalerate and one unit of N-methyl-phenylalanine (By similarity).
Similarity
Belongs to the ketopantoate reductase family.
Mass
50.063 kDa
Sequence
MASQEHPNWLTALLADTRPPPKLFAWSPANIQPKLDEGIDMGSSNSDEEYDNDACVCPSTDSDQRIYIIGPGNIGRLYATHMARHPNALPITLVVHRKELLSQWAACEGVGLADLTSGKIFLNKRFTVEWWTETRPPYGPVKEVADGKKLHNVFISTKAEAGLSEADRIRRYLGRCSSVVFAQNGVCKLWPPHGPLYISHRYPSGDTPTFSACVVSHGVASAGPFLSVHAAPADAYIGPVFWASDPESPWRQPSDDFFIRHIATTPLVNTKQVSSGEIWLLQLEKLVMNAAINPLTALLRYKTGELFTSYGSDDPLARVIDKLLWQTSAVIQGLIDHETSHSVITSYAEQMSQPGTSCSVPKVRKKLTERFSQPILKAKLYAFGLKIFEHRSSMLQDIEAGRKTEIRDFNGWIVDTACFLGTGLDVSVHSGLTGLIERCERFDKMELGRALL