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BDH2

Gene
BDH2
Protein
Probable diacetyl reductase [(R)-acetoin forming] 2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
417 amino acids
Function
Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH.
Similarity
Belongs to the zinc-containing alcohol dehydrogenase family.
Mass
46.099 kDa
Sequence
MRALAYFGKGNIRFTNHLKEPHIVAPDELVIDIEWCGICGTDLHEYTDGPIFFPEDGHTHEISHNPLPQAMGHEMAGTVLEVGPGVKNLKVGDKVVVEPTGTCRDRYRWPLSPNVDKEWCAACKKGYYNICSYLGLCGAGVQSGGFAERVVMNESHCYKVPDFVPLDVAALIQPLAVCWHAIRVCEFKAGSTALIIGAGPIGLGTILALNAAGCKDIVVSEPAKVRRELAEKMGARVYDPTAHAAKESIDYLRSIADGGDGFDYTFDCSGLEVTLNAAIQCLTFRGTAVNLAMWGHHKIQFSPMDITLHERKYTGSMCYTHHDFEAVIEALEEGRIDIDRARHMITGRVNIEDGLDGAIMKLINEKESTIKIILTPNNHGELNREADNEKKEISELSSRKDQERLRESINEAKLRHT

Gene
BDH2
Protein
3-hydroxybutyrate dehydrogenase type 2
Organism
Bos taurus
Length
245 amino acids
Function
Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
26.662 kDa
Sequence
MGRLDGKVIVLTAAAQGIGRAAALAFAKEGAKVIATDINDSKLQELDKYPGIHTRVLDVTKKKQIDQFANDIERLDVLFNVAGFVHHGTILDCEETDWDFSMNLNVRSMYLMIKAFLPKMMAQKSGNIINMSSVASSIKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTVDTPSLQERIQARPNPEEALSDFLKRQKTGRFATAEEVALLCVYLASDESAYITGNPVIIDGGWSL

Gene
bdh2
Protein
3-hydroxybutyrate dehydrogenase type 2
Organism
Danio rerio
Length
245 amino acids
Function
Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with lcn2 (By similarity). It thereby plays a key role in iron assimilation and homeostasis (PubMed:20550936). Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
26.502 kDa
Sequence
MGRLDGKVIVLSAAAQGIGKASAIAFAKEGAQVTATDINGEKLKELDGIPGIKTKVVDVTKKDQVDALAKDFDHVDVLFNIAGFVHHGSILDCEESDWDFTMNVNVRSMYLMIKAFLPKMLARKSGNIINMASVASSIKGVVNRCVYSTSKAAVIGLTKSVAADFLEQGIRCNCICPGTVDTPSLRERIQARPDPEQAFKDFMARQRTGRLCTAEEVAHLCVYLASDESTFVTGTEVIIDGGWRL

Gene
BDH2
Protein
3-hydroxybutyrate dehydrogenase type 2
Organism
Homo sapiens
Length
245 amino acids
Function
Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (PubMed:16380372).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
26.724 kDa
Sequence
MGRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQTRVLDVTKKKQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAYVTGNPVIIDGGWSL

Gene
bdh2
Protein
3-hydroxybutyrate dehydrogenase type 2
Organism
Lithobates catesbeiana
Length
245 amino acids
Function
Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with lcn2, thereby playing a key role in iron assimilation and homeostasis (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
26.587 kDa
Sequence
MGRLDGKVIVLSAGAQGIGKAAAIAFAKEGAKVIATDINGEKLKELESYKGIETRVLDVTKKDQIEKLSKEIDRIDVLFNVAGFVHHGSILDCEEADWDFTMNVNVRSMYLMIKTFLPKMLAQKSGNIINMSSVASSIKGVVNRCVYSTSKAAVIGLTKSVAADFIEQGIRCNCICPGTVDTPSLRERIEARPDPEQALKDFLARQKTGRMCTAEEVAHLCVYLASDEAAYVTGNAHIIDGGWSL

Gene
Bdh2
Protein
3-hydroxybutyrate dehydrogenase type 2
Organism
Mus musculus
Length
245 amino acids
Function
Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis (PubMed:20550936, PubMed:24863067). Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (PubMed:24863067). Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
26.753 kDa
Sequence
MGRLDGKVIVLTAAAQGIGRASALAFAREGAKVIATDINESKLQELESYRGIQTRVLDVTKKRQIDQFASEIERIDVLFNVAGFVHHGTILDCEEKDWDFSMNLNVRSMFLMIKAFLPKMLAQKSGNIINMSSVASSIKGVENRCVYSATKAAVIGLTKSVAADFIQQGIRCNCVCPGTVDTPSLQERIQARDNPKEALKTFLNRQKTGRFASAEEVALLCVYLASDESAYVTGNPVIIDGGWSL

Gene
Bdh2
Protein
3-hydroxybutyrate dehydrogenase type 2
Organism
Rattus norvegicus
Length
245 amino acids
Function
Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
26.651 kDa
Sequence
MGRLEGKVIVLTAAAQGIGRASALAFAREGAKVIATDINEAKLQELENYPGIQTRVLDVTKKRQIDQFASEIEKIDVLFNVAGFVHHGTILDCEEKDWDFSMNLNVRSMYLMIKAFLPKMLAQKSGNIINMSSVASSIKGVENRCVYSATKAAVIGLTKSVAADFIQQGIRCNCVCPGTVDTPSLQERIQARDDPKEALKAFLNRQKTGRFASAEEVALLCVYLASDESAYVTGTPVVIDGGWSL

Gene
bdh2
Protein
3-hydroxybutyrate dehydrogenase type 2
Organism
Xenopus laevis
Length
245 amino acids
Function
Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with lcn2, thereby playing a key role in iron assimilation and homeostasis (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
26.765 kDa
Sequence
MGRLDGKVIVLSAAAQGIGRAAAIAFAKEGAQVIATDVNEMKLKELEAYKGIQTRVLDVTKKDQIENLCKEIDRIDVLFNVAGFVHHGTILDCTEADWDFTMNVNVRSMYFMIKTFLPKMLAQKSGNIINMSSVASSIKGVVNRCVYSTSKAAVIGLTKSVASDFIDQGIRCNCICPGTVDTPSLRERIQARPDPEQALKDFLARQRTGRMATAEEVAHLCVYLASDESAYVTGNEHIIDGGWSL