Organism
Monkeypox virus (strain Zaire-96-I-16)
Function
Nuclease that is responsible for viral evasion of host cGAS-STING innate immunity (PubMed:30728498). Cleaves 2',3'-cGAMP which is produced by host cGAS following recognition of intracellular foreign DNA and blocks the subsequent 2',3'-cGAMP-mediated activation of TMEM173/STING which normally spreads to adjacent cells and activates the interferon and NF-kappa-B immune responses (PubMed:30728498).
Similarity
In the C-terminal section; belongs to the Schlafen protein family. Subgroup poxviridae B3 subfamily.
Sequence
MFYAHAFGGYDENLHAFPRISSTVANDVRKYSVVSVYNKKYNIVKNKYMWCNSQVNKRYIGALLPMFECNEYLQIGDPIHDLEGNQISIVTYRHKNYYALSGIGYESLDLCLEGVGIHHHVLETGNAVYGKVQHEYSTIKEKAKEMNALKPGPIIDYHVWIGDCVCQVTTVDVHGKEIMRMRFKRGAVLPIPNLVKVKVGEENDTINLSTSISALLNSGGGTIEVTSKEERVDYVLMKRLESIHHLWSVVYDHLNVVNGEERCYIHMHSSHQSPMLSTVKTNLYMKTMGACLQMDSMEALEYLSELKESGGRSPRPELQKFEYPDGVKDTESIERLAEEFFNRSELQAGESVKFGNSINVKHTSVSAKQLRTRIRQQLPSILSSFANTKGGYLFIGVDNNTHKVIGFTVGHDYLKLVERDIEKYIQKLPVVHFCKKKEDIKYACRFIKVYKPGDETTSTYVCAIKVERCCCAVFADWPESWYMDTSGSMKKYSPDEWVSHIKF