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B4R

Gene
B4R
Protein
Ankyrin repeat protein B4
Organism
Vaccinia virus (strain Copenhagen)
Length
558 amino acids
Similarity
Belongs to the poxviridae B4 protein family.
Mass
65.272 kDa
Sequence
MDFFKKEILDWSVYLSLHYIARVCSNSSTSHIIQDYNLIRTYEKVDKTIVDFLSRLPNLFHILEYGENILHIYSMDDANTNIIIFFLDRVLNINKNGSFIHNLRLSSSINIKEYVYQLVNNDHPDNRIRLMLENGRRTRHFLSYISDTVNIYICILINHGFYIDAEDSYGCTLLHRCIYHYKKSESESYNELIKILLNNGSDVDKKDTYGNTPFILLCKHDINNVELFEICLENANIDSVDFNRYTPLHYVSCRNKYDFVKLLISKGANVNARNKFGTTPFYCGIIHGISLIKLYLESDTELEIDNEHIVRHLIIFDAVESLDYLLSRGVIDINYRTIYNETSIYDAVSYNAYNTLVYLLNRNGDFETITTSGCTCISEAVANNNKIIMEVLLSKRPSLKIMIQSMIAITKNKQHNADLLKMCIKYTACMTDYDTLIDVQSLQQYKWYILKCFDEIDIMKRCYIKNKTVFQLVFCIKDINTLMRYGKHPSFVKCTSLDVYGSRVRNIIASIRYRQRLISLLSKKLDAGDKWSCFPNEIKYKILENFNDNELSTYLKIL

Gene
B4R
Protein
Ankyrin repeat protein B4
Organism
Variola virus (isolate Human/India/Ind3/1967)
Length
558 amino acids
Mass
65.173 kDa
Sequence
MDFFKKEILDWSIYLSLHYIAHACSNSSTSHIIQEYNLIRTYKKVDKTIVDFLSRWPNLFHILEYGENILHIYSMDDANTNIIIFFLDNVLNINKNGSFIHNLGLSSSINIKEYVYQLVNNDHLDNGIRLMLENGRRTRHFLSYILDTVNIYICILINHGFYIDAVDSYGCTLLHRCIYHYKKSESESYNELIKILLNNGSDVDKKDTHGNTPFILLCKHDIDNVELFEICLENANIDSVDFNGYTPLHYVSCRNKYDFVKSLISKGANVNTRNRFGTTPFYCGIIHGISLIKLYLESDTELEIDNEHIVRHLIIFDAVESLDYLLFRGVIDINYRTIYNETSIYDAVSYNAYNMLVYLLNRNGDFETITTSGCTCISKAVANNNKIIMEVLLSKQPSLKIMILSIIAITKHKQHNTNLLKMCIKYTACMTDYDTLIDVQSLQQYKWYILKCFDEIDIMKRCYIKNKTVFQLVFCTKDINTLMRYGRHPSFVKYTSLDVYGSRVRNIIASIRYRQRLISLLSKKLDVGDKWACFPNEIKYKILENFNDNELSTYLKIL

Gene
B4R
Protein
Poxin-Schlafen
Organism
Monkeypox virus (strain Zaire-96-I-16)
Length
503 amino acids
Function
Nuclease that is responsible for viral evasion of host cGAS-STING innate immunity (PubMed:30728498). Cleaves 2',3'-cGAMP which is produced by host cGAS following recognition of intracellular foreign DNA and blocks the subsequent 2',3'-cGAMP-mediated activation of TMEM173/STING which normally spreads to adjacent cells and activates the interferon and NF-kappa-B immune responses (PubMed:30728498).
Similarity
In the C-terminal section; belongs to the Schlafen protein family. Subgroup poxviridae B3 subfamily.
Mass
57.454 kDa
Sequence
MFYAHAFGGYDENLHAFPRISSTVANDVRKYSVVSVYNKKYNIVKNKYMWCNSQVNKRYIGALLPMFECNEYLQIGDPIHDLEGNQISIVTYRHKNYYALSGIGYESLDLCLEGVGIHHHVLETGNAVYGKVQHEYSTIKEKAKEMNALKPGPIIDYHVWIGDCVCQVTTVDVHGKEIMRMRFKRGAVLPIPNLVKVKVGEENDTINLSTSISALLNSGGGTIEVTSKEERVDYVLMKRLESIHHLWSVVYDHLNVVNGEERCYIHMHSSHQSPMLSTVKTNLYMKTMGACLQMDSMEALEYLSELKESGGRSPRPELQKFEYPDGVKDTESIERLAEEFFNRSELQAGESVKFGNSINVKHTSVSAKQLRTRIRQQLPSILSSFANTKGGYLFIGVDNNTHKVIGFTVGHDYLKLVERDIEKYIQKLPVVHFCKKKEDIKYACRFIKVYKPGDETTSTYVCAIKVERCCCAVFADWPESWYMDTSGSMKKYSPDEWVSHIKF