About Products Protein Database Contact

B3R

Gene
B3R
Protein
Pro-variola growth factor
Organism
Variola virus (isolate Human/India/Ind3/1967)
Length
140 amino acids
Function
Variola growth factor stimulates cellular proliferation (hyperplasia) around infected cells. This effect is beneficial for virus replication in vivo, because poxviruses replicate possibly better in proliferating cells than in quiescent cells. Acts by binding host EGFR, inducing its dimerization, autophosphorylation and leading to activation of several cellular pathways regulating cell proliferation or cell survival. The activation by host EGFR of mitogen activated protein kinases (MAPK) and extracellular-signal regulated kinases (ERK) are essential for the positive effect of vaccinia growth factor on poxvirus virulence in vivo (By similarity).
Mass
15.772 kDa
Sequence
MSMKYLMLLFAAMIIRSFANSGNAIETTLSEITNTTTDIPAIRLCGPEGDRYCFHGICIHARDIDGMYCRCSHGYTGIRCQHVVLVDYQRSEKPNTTTSYIPSPGIVLVLLVSIIVCCLLFVYRFTRRTNKLPLQDMVVP

Gene
B3R
Protein
Schlafen-like protein
Organism
Vaccinia virus (strain Copenhagen)
Length
124 amino acids
Similarity
Belongs to the Schlafen family. Subgroup poxviridae B3 subfamily.
Mass
14.379 kDa
Sequence
MKRLETIRHMWSVVYDHFDIVNGKECCYVHTHSSNQNPIPSTVKTNLYMKTMGSCIQMDSMEALEYLSELKESGGWSPRPEMQEFEYPDGVEDTESIERLVEEFFNRSELQAGKLVKFGNSINC