Organism
Variola virus (isolate Human/India/Ind3/1967)
Function
May bind interleukin-1 and/or interleukin-6 and prevent these cytokines reaching their natural receptors. In consequence the inflammatory response would be diminished and virus replication enhanced.
Similarity
Belongs to the interleukin-1 receptor family.
Sequence
MMKMTMKMMVHIYFVSLLLLLFHSYAIDIENEITDFFNKMKDTLPAKDSKWLNPTCIFGGTMNNMAAIGEPFSAKCPPIEDSLLSRRYINKDNVVNWEKIGKTRRPLNRRVKNGDLWIANYTSNDSHRMYLCTVITKNGDCIQGIVRSHVRKPSSCIPEIYELGTHDKYGIDLYCGIIYAKHYNNITWYKDNKEINIDDIKYSQTGKELIIHNPALEDSGRYDCYVHYDDVRIKNDIVVSRCKILTVIPSQDHRFKLILDSKINVIIGEPANITCTAVSTSLLFDDVLIEWENPSGWLIGFDFDVYSVLTSRGGITEATLYFKNVTEEYIGNTYKCRGHNYYFEKTLTTTVVLE